A5091663403- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Chinese history and philosophy
- Pregnancy and preeclampsia studies
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Cancer Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Biochemical Acid Research Studies
- Microbial metabolism and enzyme function
- 14-3-3 protein interactions
- Wireless Sensor Networks and IoT
- Sesquiterpenes and Asteraceae Studies
- Cancer Mechanisms and Therapy
First Affiliated Hospital of Hebei Medical University
2013-2024
Hebei Medical University
2007-2024
Nanjing Medical University
2024
Hebei General Hospital
2013-2022
Fifth Hospital of Shijiazhuang
2015-2022
Chinese Academy for Environmental Planning
2022
Shanxi University
2014-2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Shaanxi University of Science and Technology
2020
China Agricultural University
2020
Purpose To compare the difference of gut microbiota between preeclampsia (PE) and healthy normal pregnant women, providing new therapeutic strategy for preeclampsia. Methods Forty-one PE patients 45 age- pre-pregnancy body mass index- matched controls were enrolled from Nov 2021 to May 2022 in this retrospective case-control study. Fecal was detected by 16S rRNA gene sequencing, followed bioinformatics analysis including microbial α diversity, β linear discriminant effect size (LEfSe)...
Testicular seminoma is a common malignancy, accounting for 35‑50% of testicular tumors. Comprehensive therapies lead to good curative efficacy. However, the factors that affect prognosis remain be elucidated. The aim present study was analyze 3‑, 5‑ and 10‑year survival rate patients with as well associated prognosis. clinical data from 58 diagnosed were collected betweeen January 1999 2014. this group evaluated using Kaplan‑Meier method. Associated analyzed log‑rank test. results showed...
Cervical cancer (CC) is the most common human gynecological malignancy worldwide. Recently, accumulating evidences revealed critical functions of miRNAs in occurrence and development cervical cancer. In our study, we aimed to demonstrate function miR-214-3p regulating cell metastasis We showed low expression cells demonstrated downregulation promoted metastasis. Furthermore, THBS2 was identified as a novel target cells. suppressed by directly targeting 3'UTR THBS2, resulting inhibition...
FXYD3 expression is upregulated in numerous cancer cell types. The present study compared the FXDY3 normal endometrium, premalignant lesion and endometrial tissue samples, investigated correlation between clinicopathological features. was analyzed by streptavidin-peroxidase immunohistochemistry 21 18 atypical hyperplasia samples 50 tissues obtained from patients diagnosed with cancer. percentage of FXYD3-positive 0, 22, 26%, respectively. differences groups were statistically significant...
Purpose The relationship between dyslipidemia and female reproductive endocrine diseases has been increasingly studied. use of lipid-lowering drugs in treating various related diseases, including coronary heart disease, may affect diseases. Therefore, our study aims to investigate the effects on provide a basis for appropriate selection drugs. Methods In this study, we focused three drug targets statins, namely HMG-CoA reductase (HMGCR) inhibitors, proprotein convertase kexin 9 (PCSK9)...
Objectives/Hypothesis TNM‐classification inadequately estimates patient‐specific overall survival (OS). We aimed to improve this by developing a risk‐prediction model for patients with advanced larynx cancer. Study Design Cohort study. Methods developed risk prediction estimate the 5‐year OS rate based on cohort of 3,442 T3T4N0N+M0 The was internally validated using bootstrapping samples and externally patient data from five external centers (n = 770). main outcome performance as tested...
I 2 /CF 3 CO Ag-mediated iodolactonization of allenoic acids has been developed to synthesize various 6- 9-membered ring vinylic iodolactones in 16–89% yield.
Study Design. Retrospective analysis. Objective. Our goal was to provide a predictive model and risk classification system that predicts cancer-specific survival (CSS) from spinal pelvic tumors. Summary of Background Data. Primary bone tumors the are rare, thus limiting understanding manifestations these Nomograms graphical representation mathematical relationships or laws accurately predict individual survival. Methods. A total 1033 patients with between 2004 2016 were selected...
Non‑small‑lung cancer (NSCLC) is a common malignant tumor and leading cause of mortality. Tumor stem cells are associated with pathogenesis development as well invastion metastasis. In the present study, expression correlation cell markers, octamer‑binding transcription factor 4 (Oct‑4) E‑cadherin (E‑cad) in NSCLC normal lung tissue were investigated. Additionally, molecular mechanisms invasion metastasis assessed. The Oct‑4 E‑cad was examined 65 pathologically diagnosed cases using...
Identifying the driving factors of soil environmental quality is critical in raising countermeasures for managing environment efficiently and precisely. In 2018, China issued risk control standards to divide into three classes meet demands management. However, there a lack knowledge this new standard. An intensive field-sampling research (2598 top-soil samples were analyzed) was conducted agricultural land Hubei province, central China, find pollutants based on According standard, proportion...
Background Killing of targeted tumors during adoptive cell transfer therapy is associated with cytotoxic T lymphocyte (CTL) numbers, immunophenotype, tumor-specificity, and in vivo residence time, migration, distribution. Therefore, tracing persistence, distribution CTLs important for cancer immunotherapy. Methods Optimal staining concentration CTL proliferation was determined by counting kit-8 (CCK-8) assay killing efficiencies or carboxyfluorescein diacetate succinimidyl ester...
Colorectal cancer is a common malignancy of the digestive tract with high mortality rate. However, current treatment approaches such as radiotherapy and chemotherapy are ineffective. Thus, it imperative to identify ways treat recurrence metastasis. The aim present study was investigate effects cytokine‑induced killer (CIK) cells on hypoxia microenvironment immune function in colon 26 xenograft mice. A murine model carcinoma tumors were divided into CIK, normal saline (NS) control groups....
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