A5049326233- Viral Infectious Diseases and Gene Expression in Insects
- Algal biology and biofuel production
- Circular RNAs in diseases
- Aquaculture disease management and microbiota
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Silkworms and Sericulture Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Invertebrate Immune Response Mechanisms
- Silk-based biomaterials and applications
- Biodiesel Production and Applications
- Virus-based gene therapy research
- interferon and immune responses
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Marine and coastal ecosystems
- Neurobiology and Insect Physiology Research
- Plant Surface Properties and Treatments
- Insect symbiosis and bacterial influences
- Chromosomal and Genetic Variations
- Viral Infections and Immunology Research
- Urinary and Genital Oncology Studies
- Insect Utilization and Effects
- Light effects on plants
Soochow University
2015-2025
Kunming University of Science and Technology
2020-2024
Taiyuan University of Science and Technology
2024
Biotechnology Research Institute
2018-2022
First Affiliated Hospital of Zhengzhou University
2018-2020
Bladder cancer is a serious in the world, especially advanced countries. stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved many biological processes, but their roles oncogenesis CSCs unclear. Here, we identified that circGprc5a upregulated tumors CSCs. circGpr5a knockdown impairs self-renewal metastasis of CSCs, its overexpression exerts an opposite role. has peptide-coding potential functions through peptide-dependent manner....
Extrachromosomal circular DNAs (eccDNAs) has been found to be widespread and functional in various organisms. However, comparative analyses of pre- post-infection virus are rarely known. Herein, we investigated the changes expression patterns eccDNA following infection with Bombyx mori cytoplasmic polyhedrosis (BmCPV) explore role viral infection. Circle-seq was used analyze eccDNAs midgut BmCPV-infected BmCPV-uninfected silkworms. A total 5508 were identified, sizes varying from 72 bp 17...
Abstract The silkworm Bombyx mori is a poikilotherm and therefore sensitive to various climatic conditions. influence of temperature on the intestinal flora relationship between gene expression in remain unknown. In present study, changes at 48, 96 144 h following transient high treatment (THTT) 37 °C for 8 were investigated. According principal component analysis, abundances Enterococcus Staphylococcus showed negative correlation with other dominant genera. After THTT, levels spatzle-1...
Abstract Emerging evidences have demonstrated that ubiquitin-associated domain-containing protein 2 (UBAC2) is closely related to the occurrence and development of malignant tumors. However, functions underlying molecular mechanisms UBAC2 in bladder cancer (BC) not been defined. In this study, we found both mRNA levels were upregulated BC tissues cell lines, knockdown inhibited cells proliferation vitro vivo. Meanwhile, Kaplan–Meier survival plots 406 cases from TCGA database showed higher...
Hepatopancreas necrosis disease (HPND) of the Chinese mitten crab Eriocheir sinensis causes huge economic loss in China. However, pathogenic factors and pathogenesis are still a matter dissension. To search for potential pathogens, hepatopancreatic flora diseased crabs with mild symptoms, severe without visible symptoms were investigated using metatranscriptomics sequencing. The prevalence Absidia glauca Candidatus Synechococcus spongiarum decreased, whereas Spiroplasma eriocheiris increased...
Abstract The silk gland cells of silkworm are special which only replicate DNA in the nucleus without cell division throughout larval stage. extrachromosomal circular DNAs (eccDNAs) have not yet been reported silkworms. Herein, we explored characterization eccDNAs posterior A total 35 346 were identified with sizes ranging from 30 to 13 569 549 bp. Motif analysis revealed that dual direct repeats flanking 5′ and 3′ breaking points eccDNA. sequences exceeding 1 kb length present palindromic...
The findings of this study indicate that Cr-advanced steels exhibit increased corrosion resistance when Ni is incorporated into the alloy. To investigate phenomenon, products and behavior with varying contents were evaluated in CO2-saturated NaCl solutions at 90 180 °C. underlying mechanism can be elucidated from two distinct perspectives. At °C, addition causes transformation Fe oxides to NiFe2O4, it offers superior protection for steel. In addition, NiFe2O4 phase generated electronegative...
Hepatopancreas necrosis disease (HPND) is a and serious impacts on the industry of Chinese mitten crabs (Eriocheir sinensis) culture, however actual cause this still not known. In present study, to explore pathogenic changes risk factors caused by HPND, ultrathin sections different tissues from diseased were observed with transmission electron microscope. The hepatopancreatic cells, spermatogonium, gill muscle cells showed severe structural morphological changes. To further investigate...
Circular DNAs derived from single-stranded RNA viruses play important roles in counteracting viral infection. However, whether double-stranded generate functional circular is still unknown. Using circDNA sequencing, divergent PCR, DNA situ hybridization and rolling amplification, we presently confirmed that silkworm, Bombyx mori cytoplasmic polyhedrosis virus (BmCPV), a belonging to cypovirus, prone produce BmCPV-derived termed as vcDNA-S7. We have also found vcDNA-S7 formation mediated by...
Hippo signalling represents a cell proliferation and organ-size control pathway. Yorki (Yki), component of the pathway, induces transcription number targets that promote survival. The functions Yki have been characterized in Drosophila mammals, while there are few reports on silkworm, Bombyx mori . In present study, we found BmYki3 facilitates migration division, enlarges cultured wing disc size. Co-immunoprecipitation results indicated may interact with thymosin, E3 ubiquitin-protein...
Encapsulation of antigens within protein microcrystals (polyhedra) is a promising approach for the stable delivery vaccines. In this study, vaccine was encapsulated into polyhedra against cyprinid herpesvirus II (CyHV-2). CyHV-2 typically infects gibel carp, Carassius auratus gibelio, causing gill hemorrhagic disease. The constructed using codon-optimized sequence, D4ORF, comprising ORF72 (region 1–186 nt), ORF66 993–1197 ORF81 603–783 and ORF82 85–186 nt) genes CyHV-2. H1-D4ORF D4ORF-VP3...
The infectious spleen and kidney necrosis virus (ISKNV) is a highly lethal virus, which has brought significant losses to aquaculture. Therefore, new vaccine against ISKNV with high efficiency, safety convenience must be developed. While baculoviruses are more commonly used as protein expression systems for antigen production, this paper baculovirus technology develop live-vector vaccine, BacMCP, contains the coding sequence of major capsid (MCP) (GenBank accession no. AF371960) driven by...
Lung cancer is the most common cause of cancer-related death. Non-small cell lung (NSCLC) accounts for 80%-85% total cases. Dachshund homolog 1 (DACH1), a protein encoded by DACH1 gene in humans. inhibits adenocarcinoma invasion and tumor growth but has lower expression NSCLC. To investigate mechanisms decreased expression, its DNA methylation patterns were investigated. The results showed higher rate NSCLC compared with adjacent normal tissues. Cell transfection experiments that increased...