Allocation of limiting resources, such as nutrients, is an important adaptation strategy for plants. Plants may allocate different nutrients within a specific organ or the same nutrient among organs. In this study, we investigated allocation strategies nitrogen (N) and phosphorus (P) in leaves, stems roots 126 shrub species from 172 shrubland communities Northern China using scaling analyses. Results showed that N P have relationships plant The concentration across organs tended to be...

Bladder cancer is a serious in the world, especially advanced countries. stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved many biological processes, but their roles oncogenesis CSCs unclear. Here, we identified that circGprc5a upregulated tumors CSCs. circGpr5a knockdown impairs self-renewal metastasis of CSCs, its overexpression exerts an opposite role. has peptide-coding potential functions through peptide-dependent manner....

Abstract. Concentrations of leaf nitrogen (N) and phosphorus (P) are two key traits plants for ecosystem functioning dynamics. Foliar stoichiometry varies remarkably among life forms. However, previous studies have focused on the stoichiometric patterns trees grasses, leaving a significant knowledge gap shrubs. In this study, we explored intraspecific interspecific variations N P concentrations in response to changes climate, soil property, evolutionary history. We analysed 1486 samples...

Positive biodiversity-ecosystem-functioning (BEF) relationships are commonly found in experimental and observational studies, but how they vary different environmental contexts under the influence of coexisting life forms is still controversial. Investigating these variations important for making predictions regarding dynamics plant communities carbon pools global change. We conducted this study across 433 shrubland sites northern China. fitted structural equation models (SEMs) to analyze...

Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans-splicing cis-splicing between adjacent genes are also shown to generate chimeric RNAs. They influence tumor progression by coding fusion proteins, acting noncoding or circular RNAs, altering parental gene expression. Here, we analyzed The Cancer Genome Atlas Chinese Prostate Epigenome Atlas, identifying similarities differences Western prostate...

Prostate cancer (PCa) with a high incidence worldwide is serious threat to men's health. Despite the continuous development of treatment strategies for PCa in recent years, long-term prognosis patients still poor. Hence, discovery and novel, secure, efficient therapeutic approaches hold significant clinical significance. Although sorafenib (SOR) displays potential as option PCa, its efficacy hindered by drug resistance, limited water solubility, rapid metabolism. Therefore, we proposed...

Darolutamide, an androgen receptor inhibitor, has been approved by the Food and Drug Administration (FDA) for treatment of prostate cancer (PCa), especially patients with mutations. Owing to unique lipidomic profile PCa effect darolutamide, relationship between darolutamide ferroptosis remains unclear. The present study showed that significantly induces in AR

Abstract Rhus typhina , an alien species introduced from North America, was identified as a main afforestation in Beijing municipality. However, its invasiveness is still at odds. To clarify this problem, we applied the American Screening System and Australian to preliminarily predict invasion possibility. Both screening systems gave same recommendation “reject”. The geographical distribution surveyed, with population features of R. against native plant communities being assessed. With...

Abstract The density of seeds in soil seed banks and the species composition both aboveground vegetation were examined naturally restored sites (NRS) aerially seeded (ASS) Hunshandak sandlands northern China. Five 1, 2, 4, 8, 15 years ago four 5, 7 ago. In total, 36 recorded bank 41 for all NRS, whereas numbers 17 19, respectively, ASS, indicating that NRS can support higher diversity than ASS. During initial 2 restoration, introduced alien shrubs by aerial seeding dominated although there...

Abstract Plant communities differ in their fruit type spectra, especially the proportions of fleshy and non-fleshy types. However, which abiotic biotic factors drive this variability along elevation gradient what drives evolution diversity still are puzzling. We analyzed variations richness fleshy-fruited species correlations to various variables gradients three mountains Beijing region, northeast China. Fleshy-fruited species, characterized by high water contents, were found great...

Abstract Emerging evidences have demonstrated that ubiquitin-associated domain-containing protein 2 (UBAC2) is closely related to the occurrence and development of malignant tumors. However, functions underlying molecular mechanisms UBAC2 in bladder cancer (BC) not been defined. In this study, we found both mRNA levels were upregulated BC tissues cell lines, knockdown inhibited cells proliferation vitro vivo. Meanwhile, Kaplan–Meier survival plots 406 cases from TCGA database showed higher...

Neuroendocrine tumors (NETs) are rare, which has resulted in a lack of published data on their epidemiology and clinical features. We therefore aimed to investigate the epidemiology, features, treatments, prognosis patients with NETs.The clinicopathologic characteristics 547 who were pathologically diagnosed NETs retrospectively analyzed, including age, sex, primary metastatic sites, symptoms, pathology, treatment, prognosis.The had wide age range (9-87 years), male female ratio 1:1.1. The...

Abstract. Concentrations of leaf nitrogen (N) and phosphorus (P) are key traits in ecosystem functioning dynamics. Foliar stoichiometry varies remarkably among life forms. However, previous studies have focused on trees grasses, leaving the knowledge gap for stoichiometric patterns shrubs. In this study, we explored intra- interspecific variations N P concentration relation to climate, soil property evolutionary history based 1486 samples composed 163 shrub species from 361 shrubland sites...

AbstractSeedling emergence and establishment was monitored in 3 microhabitats during growing seasons a Mediterranean coastal sand dune community Poleg Stream Nature Reserve, Israel. Seedling varied temporally among the microhabitats, with delay timing of seedling shrub understoreys due to lower soil average temperatures irradiance. In contrast, on trails advanced because more intense irradiance higher their exposed surfaces. Microhabitats showed significant differences individual densities,...

Abstract Pollution can be aggravated in industrial areas if traffic exhausts are mixed with emissions under high humidity conditions. Plants growing such environments may suffer from severe stress. The impact of vehicle on urban vegetation an area Qingdao, China, was investigated by studying seven plant species at visible, physiological and chemical levels. traits certain environmental conditions were compared between a clear area, Badaguan (BDG), polluted Roadside (RS). We found that foliar...

Abstract. Propagule traits vary among biomes along geographical gradients such as longitude, but the mechanisms that underlie these variations remain unclear. This study aims to explore seed mass variation patterns of different biome types a longitudinal gradient and their underlying by involving an in-depth analysis on mass, fruit type spectra, growth forms dispersal mode spectra in Inner Mongolia northeastern China. Plant community characterization collection were conducted 26 sites...

To understand the impact of reclamation and restoration on soil microbes corresponding biogeochemical processes in cold region wetland, an experiment was established that included two cultivated treatments (upland fields soybean cultivation paddy rice cultivation), restored (with meadow forest wetland agricultural abandonment).Changes properties microbial communities across different were analyzed.The results showed following: (1) The contents SOC, TN, TP Shannon diversity, Ace Chao1 index a...

Immunotherapy is gradually emerging in the field of tumor treatment. However, because complexity microenvironment (TME), some patients cannot benefit from immunotherapy. Therefore, we comprehensively analyzed TME and gene mutations ccRCC to identify a comprehensive index that could more accurately guide immunotherapy with ccRCC. We divided into two groups based on immune infiltration activity. Next, investigated differentially expressed genes (DEGs) constructed prognostic score using...