A5028097547- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- HIV/AIDS drug development and treatment
- Cancer-related gene regulation
- HIV Research and Treatment
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Chemokine receptors and signaling
- Medicinal Plant Pharmacodynamics Research
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Neuroblastoma Research and Treatments
- Liver Diseases and Immunity
- Cytomegalovirus and herpesvirus research
- Cancer Treatment and Pharmacology
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hong Kong and Taiwan Politics
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Philippine History and Culture
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
Beijing Center for Disease Prevention and Control
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2012-2024
China Medical University
2024
Guangzhou University of Chinese Medicine
2013-2024
City University of Macau
2023
Introduction The characteristic of human immunodeficiency virus type 1 (HIV-1) is its susceptibility to erroneous replication and recombination, which plays a crucial role in the diverse dynamic variation HIV-1. spread different subtypes same population often leads emergence circulating recombination forms (CRFs). At present, main recombinant HIV-1 China are CRF07_BC, CRF01_AE, CRF08_BC B′ subtypes, while CRF55_01B has become fifth major epidemic strain after rapid growth recent years since...
The imbalance between T helper 17 (Th17) and regulatory (Treg) cells plays a key role in the progression of multiple myeloma (MM).
Background Multiple myeloma (MM), a malignant disease of plasma cells originating in the bone marrow, is influenced significantly by genetic factors. Although liposomes have been linked to MM, nature their potential causal relationship remains be elucidated. This study aims explore this using Mendelian randomization (MR) analysis. Methods Liposome-associated instrumental variables (IVs) were identified from lipidomics data 7,174 Finnish individuals within Genome-Wide Association Study (GWAS)...
Researchers have discussed Hong Kong’s localist identities, nativist sentiments, and populism, but not widely examined the extent to which populism could be perceived in education Kong. As chief participants of Occupying Central radical Anti-Extradition Bill movements Kong were students, this suggests need explore relationship between education, particularly then-controversial liberal studies textbooks. According contemporary news reports, textbooks contained much content stigmatising...
Lineage switch is very rare in blastic crisis of chronic myeloid leukemia (CML-BC). Here, we report a case CML-BC which the blast lineage switched from to B-lymphoid. A 35-year-old male was initially admitted our hospital because abdominal distention for over year and dizziness one week. Prior presentation at hospital, he visited local where his white blood cell count bone marrow (BM) smear indicated CML. Results peripheral (PB) counts, analysis, immunophenotyping by flow cytometry,...
Objective To study the expressions and correlation of serum anti-mitochondrial M2 antibodies (auti-mitochondria antibody type Ⅱ,AMA-M2),regulatory T cells,and relevant interleukin (IL) in patients with primary biliary cirrhosis (PBC),and to explore diagnostic value.Methods The samples PBC diagnosed group (n=42),disease control (n=36),and healthy controls (n=50) were collected respectively.Western Blot Method was used detect AMA-M2 CD4+CD25+ regulatory cells levels CD4+,CD8+,CD4+/CD8+...
To explore the relationship between Monoclonal Gammopathy of undetermined significance (MGUS) and Multiple Myeloma (MM) based on bioinformatics methods.In this study, we conducted to identify genes associated with MGUS MM using PubMed pubmed2ensemble (http://pubmed2ensembl.ls.manchester. ac.uk/) until 2021. Gene ontology function was used label overlapping genes, Kyoto Encyclopedia Genes Genomes analysis enriched pathways. The cluster-1 obtained from Cytoscape were analyzed by Comparative...
Multiple myeloma (MM) is a systemic hematological malignancy usually incurable. The value of some important prognostic factors may gradually decrease.We aimed to explore the non-genetic indexes, models, and significance clinical staging systems MM.A retrospective analysis was conducted on data from 110 patients with MM who first visit First Affiliated Hospital Guangzhou Medical University between September 2005 December 2018.Bone marrow plasma cell percentage (BMPC%), cystatin C (CysC), β2...
Objective To investigate the effect of meisoindigo inducing primary K562 cell apoptosis and its influence on expression conduction signal STAT5.Methods was treated with for 12 h、24 h、48 h respectively.Flow cytometry used to detect cycle,and Western blot employed examine alteration STAT5.Results ①The rate h、and 48 12.5 ± 0.69,19.4± 1.07 42.5 3.22,showing statistical significance compared control group (P＜0.05).②Meisoindigo could block at S stage,the ratio stage increased 70.48±6.34 decrease...
Objective To explore the effect of Yuduqing on apoptosis CML K562 cells cultured in vitro and its molecular mechanism.Methods In serologic pharmacological test,the were divided into 8 different groups.Serum with imatinib plus (high-dose,middle-dose,low-dose) added respectively groups cells.Morphological assessment was performed optical microscope,the rates cell cycles analysis flow cytometry at 12 h,24 h,48 h 72 time points after intervention.Results The primary normal control group had a...
Abstract Background: HDAC7 is a class IIa histone deacetylase (HDAC) that exhibits lymph-specific expression patterns in the hematopoietic system. loss or dysregulation may lead to B cell-based hematological malignancies. This study aimed explore prognostic value of patients with diffuse large cell lymphoma (DLBCL). Methods : RNA sequencing data and clinical information for DLBCL were collected from The Cancer Genome Atlas (TCGA) database analyzed using R software. Paired t Mann–Whitney U...