To investigate the clinical characteristics of patients with systemic lupus erythematosus (SLE) positive anti-ribosomal P protein antibodies and associated risk factors in a larger sample size. A single-center, retrospective study was conducted. Based on medical records in-patients from June 2009 to December 2022, SLE were divided into antibody-positive negative groups according 1:3 gender age match. This included 388 SLE, which 97 (25%) 291 (75%) for antibodies, respectively. The median all...

The incidence of rheumatoid arthritis (RA) has been reported to be correlated with a disorder immunregulation. Rheumatoid fibroblast-like synoviocytes (RA-FLSs) play an important role in regulating the local immune microenvironment. However, potential mechanism RA-FLS immnue response is not clearly understood. In this study, we demonstrated that expression HIF-1α was significantly up-regulated tissue which indicated hypoxia condition We also observed RA-FLSs up-regulate activation....

This study aim was to explore the effects of tumor necrosis factor-like weak inducer apoptosis (TWEAK) in lupus nephritis and its potential underlying mechanisms. MRL/lpr mice were used for vivo experiments human proximal tubular cells (HK2 cells) vitro experiments. Results showed that treated with vehicle solution or LV-Control shRNA displayed significant proteinuria severe renal histopathological changes. LV-TWEAK-shRNA treatment reversed these changes decreased expressions TWEAK, TGF- β...

Abstract Acute kidney injury (AKI) results in retention of waste products and dysregulation extracellular volume electrolytes, thus leading to a variety complications. Recent advances long noncoding RNAs suggested their close relationship with disease progression. In the current study, we investigated role mechanism maternally expressed gene 3 (MEG3) on AKI pathogenesis. Real‐time polymerase chain reaction found that expression MEG3 was significantly increased both tissues TKPTS cells...

To evaluate the performance of Systemic Lupus Erythematosus Risk Probability Index (SLERPI) in patients with SLE using a Chinese cohort.The cohort included 352 and 385 without (control group). The clinical data patients, including demographic data, findings serological profiles, were collected. Patients an SLERPI score >7 classified as SLE. American College Rheumatology (ACR)-1997, International Collaborating Clinics (SLICC)-2012 European League Against Rheumatism (EULAR)/ACR-2019 criteria...

Objectives. Oestrogens have been shown to play key roles in the pathogenesis of SLE. The aim this study was investigate and mechanisms 17β-estradiol (E2) TNF-like weak inducer apoptosis (TWEAK) expression LN. Methods. Peripheral blood mononuclear cells (PBMCs) obtained from LN patients were used for vitro experiments, while female MRL/lpr MRL/MpJ mice vivo studies. E2, ICI 182 780 [estrogen receptor (ER)-selective antagonist], methyl-piperidino-pyrazole (MPP, ERα-selective modulator),...

Interstitial lung disease (ILD) is a common complication of dermatomyositis (DM) and one the main risk factors for poor prognosis in DM patients. The aim this study was to reveal clinical characteristics patients with ILD.Clinical data from Second Affiliated Hospital Soochow University were used conduct retrospective case-control study. Univariate multivariate logistic regression analysis performed identify ILD DM.A total 78 included study, including 38 40 without ILD. Compared ILD, older...

The characteristics of leukopenia in patients with systemic lupus erythematosus (SLE) different studies are different, which may be related to region, race, and sample size. Moreover, the extent leukocyte count decline remains studied. This study aimed analyze clinical SLE Han ethnicity China. A single-center, retrospective, cross-sectional was conducted Chinese from June 2013 August 2020. total 125 were included study, 104 age- sex-matched healthy controls recruited. prevalence leukopenia,...

Type I interferon (IFN) plays a central role in pathogenesis of systemic lupus erythematosus (SLE); tumor necrosis factor-like weak inducer apoptosis (TWEAK) has been associated with pathogenic nephritis (LN). Thus we investigated whether TWEAK could induce the activation type IFN pathway LN. We examined this patient-derived peripheral blood mononuclear cells (PBMCs) as well MRL/lpr mice, murine LN model. Relative to control cohorts, mice showed severe histological changes, high index levels...

Background and aims Several different versions of classification criteria, including the American College Rheumatology (ACR)-1997, Systemic Lupus International Collaborating Clinics (SLICC)-2012 European Alliance Associations for (EULAR)/ACR-2019 have been launched in past decades. The current study aimed to investigate performance these three criteria diagnosing patients with SLE a Chinese cohort. Methods 352 385 controls other diseases who had detection results ANA were enrolled into...

Tubulo-interstitial injury is a poor prognostic factor for lupus nephritis (LN). Here, we tested whether iguratimod could inhibit tubulo-interstitial in LN.MRL/lpr mice, an animal model of lupus, were treated with or vehicle solution. Pathological changes kidney evaluated blindly by the same pathologist. Renal type I collagen (COL-I), IgG, E-cadherin, fibroblast-specific protein 1 (FSP-1) detected immunofluorescence, immunohistochemical staining quantitative real-time PCR. After transforming...

Abstract Objectives To explore the relationship of tumour-associated antigens (TAAs) with clinical manifestations and serological markers SLE. Methods This was a retrospective study. Clinical data SLE patients were extracted from electronic medical records, including serum levels TAAs such as alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer (CA) 19-9, CA125, CA15-3 cytokeratin 19-fragments (CYFRA21-1). TAA positivity defined level exceeding upper limit corresponding reference...

Objective: To explore the value of quantitative parameter intravoxel incoherent motion diffusion (IVIM-DWI) at 3.0 T MRI sacroiliac joint in differentiating different disease activity statuses ankylosing spondylitis (AS) and to compare it with traditional diffusion-weighted imaging (DWI) Spondyloarthritis Research Consortium Canada (SPARCC) score. Methods: 56 AS patients (active group, inactive group) 24 healthy controls were included. Clinical data, parameters IVIM-DWI MR images SPARCC...

The objective of this study was to investigate the relationship between serum tumor markers and serous effusion in systemic lupus erythematosus (SLE) patients, thereby contributing preliminary data on utility these diagnosing effusion. In retrospective analysis, clinical SLE patients were extracted from electronic medical records. This included levels markers, including pro-gastrin-releasing peptide, neuron-specific enolase (NSE), cytokeratin-19 fragments (CYFRA 21-1), various carbohydrate...

Current studies on the mechanism of tumor necrosis factor-like weak inducer apoptosis (TWEAK) in lupus nephritis (LN) mainly focus inflammatory pathway. Herein, we aimed to determine whether TWEAK could promote progression renal interstitial fibrosis by regulating peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) expression and intervening lipid metabolism LN. MRL/lpr mice, an animal model lupus, were treated with anti-TWEAK antibody or co-treated adeno-associated...

Introduction This study aimed to investigate the association between ANA and clinical characteristics as well prognosis in a cohort of patients with anti-MDA5+ DM. Material methods We conducted systematic retrospective medical records from Nanjing Medical University myositis associated interstitial lung disease (ILD) contort. Results A total 246 DM were enrolled this study, 28.5% males 71.5% females. The median age was 53.0 years, duration 2 months, follow-up period 12.0 months. positivity...