A5109520082- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Medical Imaging and Analysis
- Biochemical effects in animals
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Advanced MRI Techniques and Applications
- Apelin-related biomedical research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lower Extremity Biomechanics and Pathologies
- Chronic Kidney Disease and Diabetes
- Ophthalmology and Eye Disorders
- Hepatitis B Virus Studies
- Neurological disorders and treatments
- Retinal Imaging and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Hepatitis Viruses Studies and Epidemiology
- Dementia and Cognitive Impairment Research
Soochow University
2015-2025
Second Affiliated Hospital of Soochow University
2015-2025
First Affiliated Hospital of Henan University
2024
Integrated Chinese Medicine (China)
2024
Zhengzhou University of Science and Technology
2024
Soochow University
2022
Changzhi Medical College
2021
Shanxi Province Hospital of Traditional Chinese Medicine
2021
Yixing People's Hospital
2017-2019
Jiangsu University
2017-2019
Abstract Connexin43 (Cx43) is one of the most abundant gap junction proteins in central nervous system. Abnormal opening Cx43 hemichannels after ischemic insults causes apoptotic cell death. In this study, we found persistently increased expression 8 h to 7 d hypoxia/ischemia (HI) injury neonatal rats. Pre‐treatment with Gap26 and Gap27, two mimetic peptides, significantly reduced cerebral infarct volume. treatment at 24 ischemia improved functional recovery on muscle strength, motor...
Aim: We aim to study the antidepressant mechanism of metformin. Materials & methods: Tail suspension test and forced swimming were used detect depression-like behavior; expressions target protein examined by western blot; levels genes tested quantitative PCR; content α-ketoglutarate 5hmC detected ELISA kit. Results: showed that metformin can improve behavior in spatial restraint stress model; then we found through AMPK/Tet2 pathway increasing expression BDNF antidepression. Conclusion: Our...
Esophageal squamous-cell carcinoma (ESCC) metastasis is the major cause of death this severe and common malignancy. Focal adhesion kinase (FAK) one key components focal complex, which a multi-protein structure that controls cell adhesion, migration invasion regulates tumor metastasis.
// Zhiqiang Xu 1, * , Cuihua Leng Bo Yang Haili Wang 2 Jing Sun 1 Zhaoxia Liu Lingli Wei Ge and Jiangtao Zhu 3 Department of Neurology, The Second Affiliated Hospital Soochow University, Suzhou City, Jiangsu, China Xuzhou Medical Radiology, These authors have contributed equally to this work Correspondence to: Zhu, email: jiangtaozhu@126.com Ge, gw1003@163.com Keywords: acute ischemic stroke, large cerebral artery stenosis, cystatin C, risk factors Received: March 10,...
Sleep disorders and sarcopenia could contribute to the development of Alzheimer's disease (AD), which are risk factors that rapidly deteriorate cognitive functions. However, few studies have evaluated relationship between sleep in female AD patients, who a higher prevalence than male patients. This study aimed investigate status patients with mild moderate AD.This cross-sectional recruited 112 outpatients aged 60 85 years. Demographic characteristics, appendicular skeletal muscle mass index...
Objective: To investigate the correlation between specific fiber tracts and grip strength cognitive function in patients with Alzheimer's disease (AD) by fixel-based analysis (FBA).Methods: AD were divided into low (AD-LGS, n=29) without (AD-nLGS, n=25), along 31 normal controls (NC).General data, neuropsychological tests, cranial magnetic resonance imaging (MRI) scans collected.FBA evaluated white matter (WM) metrics, including density (FD), crosssectional (FC), cross-sectional area...
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressively worsening cognitive decline and memory loss. Excessive iron accumulation produces severe impairment. However, there are no uniform conclusions about changes in brain content AD. This study aimed to investigate the of deep nuclei AD, its correlation with function. Methods Thirty-one patients mild moderate 17 impairment (MCI), 20 age-, sex-, education-matched healthy controls (HC) were...
Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) technique was used to detect the changes of locus coeruleus (LC) signals in Alzheimer's disease patients (AD), and analyze its correlation with cognitive function.A total 27 AD, 15 mild impairment (MCI), 25 healthy controls (HC) were examined by NM-MRI technique. ImageJ software measure LC signals. The signal contrast ratios (LC-CRs) calculated, along measurement neuropsychological scales.The LC-CRs AD significantly different from...
Objective: To explore the value of quantitative parameter intravoxel incoherent motion diffusion (IVIM-DWI) at 3.0 T MRI sacroiliac joint in differentiating different disease activity statuses ankylosing spondylitis (AS) and to compare it with traditional diffusion-weighted imaging (DWI) Spondyloarthritis Research Consortium Canada (SPARCC) score. Methods: 56 AS patients (active group, inactive group) 24 healthy controls were included. Clinical data, parameters IVIM-DWI MR images SPARCC...
We investigated the application value of nanocarbon lymphatic tracer in thoraco-laparoscopic esophagectomy.A total 80 patients were enrolled and randomly divided into experimental group (N.=40) control (N.=40). Patients injected with suspension before esophagectomy, while underwent an operation. The lymph node resection was observed after operation.Our results showed that incidence recurrent laryngeal nerve injury less than group. complication rate significantly number black-stained nodes...
We collected diffusion-weighted images of all subjects and divided them into four groups: HC, MCI, mild AD moderate AD. The differences FD, FC FDC were analyzed by FBA method. results showed that the three metrics in group significantly lower than those HC Group, but there was no significant difference MCI Group. This study indicates is a microstructural or macrostructural degeneration white matter patients.