A5082956701- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- Connective tissue disorders research
- Cardiovascular Issues in Pregnancy
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Vascular Anomalies and Treatments
- Signaling Pathways in Disease
- Gout, Hyperuricemia, Uric Acid
- Takotsubo Cardiomyopathy and Associated Phenomena
Peking University Third Hospital
2024-2025
Peking University
2024-2025
Changhai Hospital
2015-2024
Second Military Medical University
2015-2024
Hunan University
2024
Temple University
2015-2018
Lower dietary energy intake (DEI) may be associated with increased mortality risk. This study aims to analyze the influence of baseline DEI, time average and other factors on survival in peritoneal dialysis (PD) patients. It was a single-center retrospective cohort study. Patients who started PD from January 2006 June 2021 were included this followed up until 2023. Their (six months after beginning PD) demographic, intake, laboratory data, varying data collected analyzed. The relationships...
// Guo-Kun Wang 1,* , Song-Hua Li 2,* Zhi-Min Zhao 1 Su-Xuan Liu 2 Guan-Xin Zhang Fan Yang Feng Wu 3 Xian-Xian and Zhi-Yun Xu Institution of Cardiac Surgery, Department Cardiovascular Changhai Hospital, Second Military Medical University, Shanghai, China Cardiology, 98th Huzhou, Zhejiang, * These authors have contributed equally to this work Correspondence to: Zhi-yun Xu, email: Zhao, Keywords : pulmonary arterial hypertension, heat shock protein 90, artery smooth muscle cells, arteriole...
A serum metabolomic method based on ultra-high-performance liquid chromatography coupled with mass spectrometry was developed to characterize hyperuricemia-related metabolic profiles and delineate the mechanism of Sanmiao wan (SMW), a traditional Chinese medicine (TCM), in treating hyperuricemic rats. With partial least-squares discriminant analysis for classification selection biomarkers, 13 potential biomarkers mouse were identified screen, primarily involved purine metabolism, arginine...
Abstract Acute kidney injury (AKI) results in retention of waste products and dysregulation extracellular volume electrolytes, thus leading to a variety complications. Recent advances long noncoding RNAs suggested their close relationship with disease progression. In the current study, we investigated role mechanism maternally expressed gene 3 (MEG3) on AKI pathogenesis. Real‐time polymerase chain reaction found that expression MEG3 was significantly increased both tissues TKPTS cells...
The last decade has witnessed considerable improvement in design and implantation techniques for the percutaneous closure of perimembranous ventricular septal defects. This study was undertaken to compare results economic analysis traditional surgery with a modified double-disk occluder during hospitalization. A total 345 consecutive patients who underwent isolated defect were identified between July 2009 2011 our institution. 157 (45.5%) remaining 188 (54.5%) treated surgically. In group,...
Background:Transcatheter closure is a well-established therapy for patients with perimembranous ventricular septal defects (VSDs), but limited experience in intracristal VSDs (IVSDs) aortic cusp prolapse (ACP).Methods and Results:From 2012 to 2014, we reviewed 38 IVSDs complicated mild ACP who underwent device closure, and, light of the findings, assessed effect transcatheter intervention on preoperative ACP. The zero eccentric VSD occluder was chosen (Shanghai Shape Memory Alloy Ltd,...
This study was undertaken to compare the clinical results of traditional surgery and a percutaneous procedure for secundum type atrial septal defect (ASD) combined with pulmonary valve stenosis (PS). A total 78 consecutive patients were identified between March 2004 July 2012 in our institution. Thirty-five (44.9%) underwent correction remaining 43 (55.1%) treated surgically. All had simultaneous complete both groups no serious complications occurred. The surgical group significantly younger...
To evaluate the safety and efficacy of percutaneous closure (PC) using modified double-disc ventricular septal defect (VSD) occluders in patients with ruptured sinus Valsalva aneurysm (RSVA).Between 2005 2012, 25 were enrolled our study for attempted PC. There five (20%) RSVA combined VSD two (8%) aortic regurgitation (AR). The median age was 45 years (24-74 years). QP/QS 2.4±0.6 (1.6-4.0). diameter lesions 6 mm (4-8 mm) while size 8 (6-12 mm). Twenty-three (92%) underwent PC successfully....
Abstract Thoracic aortic aneurysm (TAA) is progressive fatal pathological dilation, which characterized by increased proteoglycans and loss of elastic fibers. Recent advances in long non‐coding RNAs (lncRNAs), an important regulator many biological processes, suggested the close correlation between expression patterns disease progression. In present study, ascending tissues were collected from TAA patients ( n = 33) organ donors 16). Microarray analysis real‐time PCR then applied to detect...
Autophagy is a ubiquitous intracellular process for cellular homeostasis maintenance by recycling damaged protein and organelles. Dysregulation of cardiomyocytes autophagic activity implicated in various heart diseases. Recent studies had demonstrated that long non-coding RNAs (lncRNAs) played crucial roles on modulation activity. In this study, we first established an angiotensin II-induced autophagy model neonatal rat cardiomyocytes. Western blot assay confirmed the expression Beclin 1...
Exercise preconditioning (EP) attenuates pathological cardiac hypertrophy by increasing the functional capacity of cardiovascular system; however, underlying molecular mechanisms remain unclear. MicroRNAs (miRNAs) play important roles in various physiological and processes regulating expression targeted gene. In this study, we aimed to screen miRNAs involved EP-attenuating hypertrophy. The histological echocardiographic parameters assessment showed that induced transverse aortic constriction...