A5101927029- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Innovative Energy Harvesting Technologies
- Neuroscience and Neural Engineering
- Wireless Power Transfer Systems
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Proteoglycans and glycosaminoglycans research
- Paraoxonase enzyme and polymorphisms
- Circular RNAs in diseases
- Bone Tissue Engineering Materials
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- EEG and Brain-Computer Interfaces
- Plant Surface Properties and Treatments
- Xenotransplantation and immune response
- Conducting polymers and applications
- Biochemical Acid Research Studies
- RNA modifications and cancer
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Cynara cardunculus studies
Changhai Hospital
2007-2021
Second Military Medical University
2007-2021
Harvesting biomechanical energy in vivo is an important route obtaining sustainable electric for powering implantable medical devices. Here, we demonstrate innovative triboelectric nanogenerator (iTENG) harvesting. Driven by the heartbeat of adult swine, output voltage and corresponding current were improved factors 3.5 25, respectively, compared with reported performance conversion In addition, evaluation iTENG was demonstrated over 72 h implantation, during which generated electricity...
Implantable medical devices are widely used for monitoring and treatment of severe diseases. In particular, an implantable cardiac pacemaker is the most effective therapeutic device treating bradyrhythmia, however its surgical replacement inevitable every 5–12 years due to limited life built-in battery. Although several approaches energy harvesting have been explored in this decade powering pacemakers, modern, commercial, full-function has never powered effectively yet. Here, we report...
Brahma-related gene 1 (BRG1) and long non-coding RNAs (lncRNAs) play important roles in cellular processes. However, little is known regarding their thoracic aortic aneurysms. We investigated BRG1 expression aneurysms the of lncRNA HIF alpha-antisense RNA regulating proliferation apoptosis smooth muscle cells vitro. mRNA protein human media specimens were examined by quantitative real-time polymerase chain reaction, immunohistochemical staining western blot. was up-regulated lentiviral...
Abstract Over the past half‐century, cardiac pacing technology has adhered to one basic system. However, many pacemaker‐related complications are related this system, particularly in terms of power supply and leads. Here, for first time a heart‐worn pacemaker strategy is presented, which allows batteryless powering leadless pacing. The feature attained via heart‐extrusion energy scavenging through micromachined piezoelectric thick film transducer. A record vivo output current 30 µA obtained...
Various detergent-based protocols are used to remove cells and cellular debris in porcine aortic valve (PAV). However, the removal of antigenic components has not been thoroughly elucidated date. In this study, we 4 decellularize PAVs aimed evaluate their effects on removing components.Porcine valves were decellularized using sodium dodecyl sulfate (SDS), SDS combination with deoxycholate (SDS/SD), Triton X-100, X-100 SD (Triton X-100/SD), respectively. Untreated as controls....
Over the past half-century, cardiac pacing technology has been reported. In this study, we designed, prepared, and tested performance of a self-energized pacemaker driven by piezoelectric vibration energy collection technology, which converts kinetic heart into electrical energy. A record in vivo output current 54 nA was obtained an adult rat implanted transducer.First, collected collector supplied to pacemaker. Then, pierced from outside, tissue stimulated electrode, self-powered pacing.The...
Mammalian sterile 20-like kinase 1 (Mst1) is a critical component of the Hippo signaling pathway, which regulates variety biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression in mammals. Mst1 plays essential roles heart disease since its activation causes cardiomyocyte dilated cardiomyopathy. However, mechanism underlying remains unknown. In yeast two-hybrid screen human cDNA library with as bait, glyceraldehyde-3-phosphate...
Autogenous vein grafting is widely used in regular bypassing procedures. Due to its mismatch with the host artery both mechanical property and geometry, graft often over expands under high arterial blood pressure forms a step-depth where eddy flow develops, thus causing restenosis, fibrous wall, etc. External stents, such as sheaths being cuff graft, have been introduced eliminate these mismatches increase patency. Although histological immunochemical studies shown some positive effects of...
Abstract Thoracic aortic aneurysm (TAA) is progressive fatal pathological dilation, which characterized by increased proteoglycans and loss of elastic fibers. Recent advances in long non‐coding RNAs (lncRNAs), an important regulator many biological processes, suggested the close correlation between expression patterns disease progression. In present study, ascending tissues were collected from TAA patients ( n = 33) organ donors 16). Microarray analysis real‐time PCR then applied to detect...
Abstract Background The design and fabrication of porous scaffolds are important issues for tissue engineering applications. In this study, we attempted to fabricate using bovine pericardium (BP) examined whether these were beneficial cell ingrowth bioactive factors delivery. Methods A vacuum‐freeze‐thawing‐Triton X‐100 (VFTT) protocol was used BP scaffolds. mechanical properties assessed histology, scanning electron microscopy, assay. fabricated seeded with mesenchymal stem cells (MSCs),...