A5100359472- CRISPR and Genetic Engineering
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Brucella: diagnosis, epidemiology, treatment
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Gastric Cancer Management and Outcomes
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Reproductive biology and impacts on aquatic species
- Animal Diversity and Health Studies
- Advanced biosensing and bioanalysis techniques
- Aquaculture Nutrition and Growth
- Metastasis and carcinoma case studies
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Escherichia coli research studies
- Reproductive Biology and Fertility
- Plant-derived Lignans Synthesis and Bioactivity
- Microbial Natural Products and Biosynthesis
- Metabolism and Genetic Disorders
- Phytochemistry and Biological Activities
- Methane Hydrates and Related Phenomena
- Esophageal and GI Pathology
Hunan Normal University
2018-2025
Henan Polytechnic University
2020-2024
Guangdong Medical College
2024
Guangdong University of Petrochemical Technology
2024
Guilin University of Electronic Technology
2024
Model Animal Research Center
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Northwest A&F University
2023-2024
Nanjing University
2024
Guiyang College of Traditional Chinese Medicine
2024
Abstract Heat removal and thermal management are critical for the safe efficient operation of lithium-ion batteries packs. Effective dynamically generated heat from cells presents a substantial challenge optimization. This study introduces novel liquid cooling method aimed at improving temperature uniformity in battery pack. A complex nonlinear hybrid model is established through traditional full-factor design back propagation neural network (BPNN) approximation. links input parameters such...
Abstract This study proposes a stepped-channel liquid-cooled battery thermal management system based on lightweight. The impact of channel width, cell-to-cell lateral spacing, contact height, and angle the effectiveness control (TCS) is investigated using numerical simulation. weight sensitivity factor adopted to evaluate effect TCS (mTCS) maximum temperature (Tmax) pack. Results suggest that width plays most critical role, followed by spacing angle, while height has minimal influence. Four...
Abstract We describe here a CRISPR simultaneous and wide-editing induced by single system (SWISS), in which RNA aptamers engineered crRNA scaffold recruit their cognate binding proteins fused with cytidine deaminase adenosine to Cas9 nickase target sites generate multiplexed base editing. By using paired sgRNAs, SWISS can produce insertions/deletions addition Rice mutants are generated the efficiencies of cytosine conversion 25.5%, adenine 16.4%, indels 52.7%, triple mutations 7.3%. The...
Abstract. Proglacial lakes are rapidly expanding due to climate change and glacier retreat. Eukaryotic microorganisms play a crucial role in the biogeochemical cycles of these lakes. However, there is limited understanding formation processes eukaryotic microbial communities their responses material cycling proglacial lakes, which land reservoirs new habitats for biological evolution meltwater, particularly at different developmental stages. This study investigates distribution patterns...
This study aimed to investigate the associations between chrononutrition profile, social jet lag (SJL) with obesity-related indicators (body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and percentage of body fat (PBF)). cross-sectional was conducted among college students in a university Hunan Province, China, from 14 September 2023 8 June 2024. employed Chrononutrition Profile – Questionnaire (CP-Q) along physical examinations. SJL defined as time difference...
Acute kidney injury is a common complication of major surgery. However, acute occurring within the first 48 hours after surgery (early injury) and therefore likely related to itself possibly different from (late injury). The aim this study was describe epidemiology identify differences in risk factors outcomes between early late following surgery.Retrospective cohort study.Academic Medical Center.Patients admitted ICU noncardiac surgery.None.We analyzed data 3,499 patients defined according...
Preadipocyte determination expanding the pool of preadipocytes is a vital process in adipocyte hyperplasia, but molecular mechanisms underlying this are yet to be elucidated. Herein, SRY-related HMG box transcription factor 4 (SOX4) was identified as critical target response BMP4- and TGFβ-regulated preadipocyte determination. SOX4 deficiency sufficient promote mesenchymal stem cells (MSCs) acquisition properties nonadipogenic lineages, while its overexpression impairs adipogenic capacity...
Systemic fungal infections contribute to at least 10% of deaths in hospital settings. Most antifungal drugs target ergosterol (polyenes) or its biosynthetic pathway (azoles and allylamines), beta-glucan synthesis (echinocandins). Antifungal that proteins are prone the emergence resistant strains. Identification genes whose mutations lead targeted resistance can provide new information on those pathways. We used Aspergillus nidulans as a model system exploit tractable sexual cycle calcofluor...
A Gram-stain-negative, rod-shaped, strictly aerobic, motile bacterial strain, designated YM319T, was isolated from a seamount near the Yap Trench in tropical western Pacific. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain YM319T related to genus Oceanisphaera and had highest similarities with type strains profunda SM1222T (97.4 %), sediminis TW92T (97.3 %) ostreae T-w6T (97.1 %). The predominant cellular fatty acids were summed feature 3 (composed of iso-C15 : 0...
Alpha-1,3-glucan is important for pathogenesis by Aspergillus fumigatus, but the mechanism unclear since deletion has no hyphal phenotype. We dissected roles of A. nidulans α-1,3-glucan in constitutive overexpression strains. Constitutive high-level synthase activity increased wall thickness, colonies grew slowly and sporulated poorly had much higher adhesion to hydrophobic materials. Surprisingly, this strain formed a biofilm-like structure plastic culture wells that was as adhesive...
The Gram-stain-negative, rod-shaped, strictly aerobic, motile bacterial strain, designated YM155T, was isolated from a seamount near the Yap Trench in tropical western Pacific. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain YM155T related to genus Thalassotalea and had highest similarities with type strains of piscium T202T (97.2 %) agariperforans M-M1T %). predominant cellular fatty acids were C17 : 1ω8c, summed feature 3 (composed iso-C15 0 2-OH and/or C16 1ω7c)...
A high ratio of severe mitochondrial defects causes multiple human diseases. However, until now, the