A5086627131- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Phytochemical Studies and Bioactivities
- Colorectal Cancer Treatments and Studies
- Financial Distress and Bankruptcy Prediction
- Peptidase Inhibition and Analysis
- Imbalanced Data Classification Techniques
- Traditional Chinese Medicine Analysis
- Protein Degradation and Inhibitors
- Polysaccharides and Plant Cell Walls
- Clusterin in disease pathology
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Blood properties and coagulation
- Ginger and Zingiberaceae research
- Medicinal Plant Pharmacodynamics Research
- Radiomics and Machine Learning in Medical Imaging
- Vehicle License Plate Recognition
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Pharmacogenetics and Drug Metabolism
- Cancer therapeutics and mechanisms
First Affiliated Hospital of Zhengzhou University
2018-2021
ORCID
2021
China University of Geosciences
2021
Zhengzhou University
2018-2020
Huazhong University of Science and Technology
2015
Hypoxia is a hallmark of many solid tumors, and it causes the overexpression variety proteins including epidermal growth factor receptor (EGFR). Many antitumor prodrugs have been designed to target hypoxia. Here we report identification kind hypoxia-activated proteolysis targeting chimera (ha-PROTAC) by introducing leaving group (1-methyl-2-nitro-1H-imidazol-5-yl)methyl or 4-nitrobenzyl into structure an EGFRDel19-based PROTAC. Among obtained molecules, ha-PROTAC 13 exhibits more potent...
Polyphyllin VI, a main active saponin isolated from traditional medicinal plant Paris polyphylla, has exhibited antitumor activities in several cancer cell lines. In the present study, we investigated effect of VI against human osteosarcoma cells (U2OS) and underlying molecular mechanisms.The U2OS lines were used to determine antiproliferative by CCK8 assay. Cell cycle was analyzed flow cytometry. The VI-induced apoptosis determined Annexin V-APC/7-AAD detection kit JC-1 staining. Meanwhile,...
Background: Drug resistance to chemotherapeutic drugs or targeted medicines is an obstacle encountered in the treatment of non-small-cell lung cancer (NSCLC).However, mechanisms competing endogenous RNA (ceRNA) on drug NSCLC are rarely reported.In this paper, comprehensive expression profiles lncRNAs and mRNAs drug-resistant cells were obtained by sequencing.Methods: The dysregulated lncRNAs, miRNAs cell lines identified RNA-sequencing bioinformatics methods.Results: A total 39 650 between...
Background/Aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim this study was identify expression profiles microRNAs (miRNAs) in drug-resistant NSCLC lines. Methods: miRNAs lines were examined using miRNA sequencing, and common dysregulated these identified analyzed by bioinformatics methods. Results: A total 29 upregulated 36 downregulated found lines, which 26 be involved Ras signaling pathway. levels, survival analysis, receiver...
Abstract Background Epimedin C, one of the main active ingredients Epimedium, has been reported to have potential hepatotoxicity. However, mechanism C-induced liver injury not studied. mRNA methylation, mainly including N 6-methyladenosine and 5-methylcytidine, is implicated in regulation many biological processes diseases. The study quantifying methylation alterations mice may contribute clarify its Therefore, an analysis method needs be established determine nucleoside methyl-nucleoside...
Credit card transaction data belongs to imbalanced data. It is necessary identify whether the credit at risk of fraud by analyzing previous data, so as deal with in time. Aiming problem that a traditional classifier cannot achieve good results dealing classification, Support Vector Machine (SVM) model optimized Genetic Algorithm (GA) proposed this paper. First, cluster centroids sampling used make dataset relatively balanced. Second, we employ GA optimize parameters SVM and select optimal...
Abstract Background Epimedium, the crude drug used in clinical, has been proved to have potential cause liver damage patients. As one of main active ingredient Epimedin C is reported hepatotoxicity. However, mechanism C-induced mice injury not studied. mRNA methylation implicated regulation many biological processes and diseases. The study may contribute clarify toxicity C. Therefore, an analysis method needs be established determine nucleoside methy-nucleoside levels epigenetic studies....