Inflammation plays an essential role in the pathogenesis of hypertension. A novel inflammatory biomarker systemic response index (SIRI) is related with all-cause and cardiovascular (CVD) mortality, while SIRI hypertension patients unclear.A total 21,506 participants were recruited National Health Nutrition Examination Survey (NHANES) from 1999 to 2018. was calculated as neutrophil count * monocyte count/lymphocyte count. Hypertension defined according examination blood pressure,...

The signaling mediated by stress-activated MAP kinases (MAPK), c-Jun N-terminal kinase (JNK) has well-established importance in cancer. In the present report, we investigated effects of curcumin on pathway human gastric cancer BGC-823 cells. Curcumin induced reactive oxygen species (ROS) production and cells apoptosis. Inhibition ROS generation antioxidant (NAC or Trion) significantly prevented curcumin-mediated Notably, observed that activated ASK1, a MAPKKK is oxidative stress sensitive...

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality and an increasing incidence worldwide; however, there are very few effective diagnostic approaches prognostic biomarkers.One hundred forty-nine pairs HCC samples from Gene Expression Omnibus (GEO) were obtained to screen differentially expressed genes (DEGs) between normal samples. The Kyoto Encyclopedia Genes Genomes (KEGG) pathway, ontology enrichment analyses, protein-protein interaction network used. Cox proportional...

Background: Curcumin, a phenolic compound extracted from the rhizomes of Curcuma longa, has shown cytotoxic effects against variety cancers. The aim this study was to identify potential microRNA (miRNA) mediators anticancer curcumin in ovarian cancer cells. Materials and Methods: SKOV3 cells were treated with (<TEX>$10-60{\mu}M$</TEX>) miR-9 expression, cell proliferation, apoptosis assessed. depletion on curcumin-mediated growth suppression also examined. Phosphorylation Akt forkhead box...

Brain microvascular endothelial cell (BMEC) survival and angiogenesis after ischemic stroke has great significance for improving the prognosis of stroke.Abnormal variants lncRNAs are closely associated with stroke.In this study, we examined effects molecular mechanisms differentiation antagonizing non-protein coding RNA (DANCR) on apoptosis, migration, oxygen-glucose deprivation (OGD)-treated BMECs.We found that DANCR expression significantly increased at 2, 4, 6, 8, 10 h OGD.DANCR...

Glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptor dual agonist have promising therapeutic effects in the treatment of obesity diabetes. Moreover, GLP-1 cholecystokinin 2 (CCK2 ) agonists been shown to restore pancreas function improve glycaemic control preclinical studies. We describe, for first time, beneficial GLP-1/glucagon GLP-1/CCK2 agonists, which can be integrated into one peptide, resulting significant anti-diabetes anti-obesity effectiveness.The vitro potency this novel...

CD204 is a specific marker of tumor-associated macrophages (TAMs) in glioma. However, the expression levels and its involvement glioma are not fully understood. In this large-scale study, we assessed function whole-grade molecularly clinically. total, 1323 samples, including 301 microarray data 325 RNA-seq from Chinese Glioma Genome Atlas (CGGA) dataset 697 The Cancer (TCGA) dataset, were utilized. statistical analysis graphical work mainly performed using R software. Univariate multivariate...

Chronic inflammation plays an essential role in the occurrence and progression of cardiometabolic diseases (CMDs). We aim to examine association between a novel inflammatory biomarker Systemic Inflammatory Response Index (SIRI) different multimorbidity (CMM) statuses. This was cross-sectional study that includes general participants National Health Nutrition Examination Survey database from 1999 2018. SIRI calculated as neutrophil count × lymphocyte count/monocyte count. The CMDs were...

Objective The study investigated the association between triglyceride–glucose (TyG) index (a surrogate measure for insulin resistance) and all-cause cardiovascular disease (CVD) mortality among individuals with cardiovascular–kidney–metabolic syndrome. Design Population-based cohort study. Setting US National Health Nutrition Examination Survey, 1999–2018. Participants A total of 13 585 participants who had valid data were included in this analysis. Outcome measures Data from linked to death...

ABSTRACT The immune microenvironment includes cells, cytokines, extracellular matrix, vesicles, etc. interactions between these components form a unique local microecology. Although immunity serves as the defense against external pathogens, aberrant activation often contributes to disease development. Chronic diseases, broad category of noncommunicable conditions characterized by long latency and prolonged course, are increasingly recognized for their intricate relationship with...

Abstract Background Glioma is the most common central nervous system tumor in adults, and a considerable part of them are high‐degree ones with high malignancy poor prognosis. At present, classification treatment glioma mainly based on its histological characteristics, so studies at molecular level needed. Methods RNA‐seq data from The Cancer Genome Atlas (TCGA) datasets (n = 703) Chinese (CGGA) were utilized to find out differentially expressed RNA‐binding proteins (RBPs) between normal...

Previous studies have indicated that a pro-inflammatory diet is associated with non-alcoholic fatty liver disease (NAFLD), but the role of BMI remains ambiguous. We aim to study intermediary effect on relationship between dietary inflammatory properties and NAFLD.A total 19536 adult participants from National Health Nutrition Examination Surveys (NHANES) were included. Dietary index (DII) was used evaluate NAFLD diagnosed by non-invasive biomarkers. Weighted multivariable logistic regression...

ABSTRACT Background MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains unknown how contributes the process of atherosclerosis. Methods Twenty fresh tissues and a total 28 wax block specimens from carotid endarterectomy procedures were obtained Luoyang Central Hospital affiliated Zhengzhou University. The expression was assessed using quantitative RT‐PCR (qRT‐PCR). A series vitro experiments used...

A clinical trial proved the effectiveness of perfusion imaging-guided intravenous thrombolysis with alteplase for patients acute ischemic stroke (AIS) time onset between 4.5 and 9 hours. This study aimed to assess lifetime cost-effectiveness versus placebo from perspective Chinese United States (US) healthcare payers.

The mutations of epidermal growth factor receptor are detected in gastric cancer, indicating its suitability as a target for tyrosine kinase inhibitors, well marker clinical outcome chemotherapeutic treatments. However, extraction quality tumor tissue molecular processes remains challenging. Here, we aimed to examine the relevance urinary cell–free DNA an alternative material source used specifically monitoring mutations. Therefore, 120 cancer patients with and 100 healthy controls were...

Objective Recently, a randomised controlled trial (DIRECT-MT) demonstrated that mechanical thrombectomy (MT) was non-inferior to MT with intravenous alteplase as the functional outcomes. This study aims investigate whether alone is cost-effective compared in China. Methods A Markov decision analytic model built from Chinese healthcare perspective using lifetime horizon. Probabilities, costs and outcomes data were obtained DIRECT-MT other most recent/comprehensive literature. Base case...

Background: Although ticagrelor plus aspirin is more effective than alone in preventing the 30-day risk of a composite stroke or death patients with an acute mild-to-moderate ischemic (IS) transient attack (TIA), cost-effectiveness this combination therapy remains unknown. This study aims to determine compared alone. Methods: A decision tree and Markov model was built estimate expected costs quality-adjusted life-years (QALYs) associated treatment IS TIA. Model inputs were extracted from...

Background: Glioblastoma multiforme (GBM) is a fatal type of brain tumor with high incidence among elderly people. Temozolomide (TMZ) has proven to be an effective chemotherapeutic agent significant survival benefits. This study aimed evaluate the economic outcomes radiotherapy (RT) and TMZ for treatment newly diagnosed GBM in people United States (US) China. Methods: A partitioned model was constructed RT plus alone patients methylated unmethylated status. Base case calculations one-way...

Abstract Background Chronic inflammation plays an essential role in the occurrence and progression of cardiometabolic diseases (CMDs). We aim to examine association between a novel inflammatory biomarker systemic response index (SIRI) different multimorbidity (CMM) status. Methods This is cross-sectional study that include general participants National Health Nutrition Examination Survey (NHANES) database from 1999 2018. SIRI was calculated as neutrophil count × lymphocyte count/monocyte...

In present study, a novel minocycline hydrochloride sustained-release capsule was prepared with the new extrusion-spheronization method. The in vitro release studies were performed using marketed sample as reference and data analyzed terms of cumulative amounts function time. Results demonstrated that developed analysis method reliable convenient for quantification dissolution study hydrochloride. characteristics different batches preparations quite similar each other, similarity factors f2...