A5040108286- MicroRNA in disease regulation
- Liver physiology and pathology
- Water Systems and Optimization
- Hydraulic and Pneumatic Systems
- Animal Virus Infections Studies
- Drug Transport and Resistance Mechanisms
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
- Chronic Myeloid Leukemia Treatments
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Wnt/β-catenin signaling in development and cancer
- RNA Interference and Gene Delivery
- Quinazolinone synthesis and applications
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Heat shock proteins research
- Liver Diseases and Immunity
- Bone Metabolism and Diseases
- Platelet Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cavitation Phenomena in Pumps
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Wuhan University
2011-2023
Zhongnan Hospital of Wuhan University
2023
Hubei Provincial Center for Disease Control and Prevention
2023
State Key Laboratory of Reproductive Medicine
2017
Nanjing Medical University
2017
Epithelial–mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evidence suggest that miRNAs have crucial roles control EMT EMT-associated traits such migration, chemoresistance. Here, we found miR-218 expression levels were significantly downregulated cancer tissues compared with adjacent non-cancerous tissues, associated histological grades lymph node...
P85α, which acts as a tumour suppressor, is frequently found to be downregulated in various human cancers. However, the role of p85α microenvironment unknown. Here, we report that aberrantly low expression breast cancer stroma clinically relevant disease progression. Stromal fibroblasts can acquire hallmarks cancer-associated (CAFs) result loss expression. Paracrine Wnt10b from p85α-deficient promote progression via epithelial-to-mesenchymal transition (EMT) induced by canonical Wnt pathway....
Sorafenib is a potent inhibitor against Raf kinase and several receptor tyrosine kinases that has been approved for the clinical treatment of advanced renal liver cancer. Combining sorafenib with other agents shown to improve its antitumour efficacy by not only reducing toxic side effects but also preventing primary acquired resistance sorafenib. We have previously observed tetrandrine exhibits in human hepatocellular carcinoma. In this study, we investigated synergistic activity combination...
Three-dimensional unsteady turbulent flow through the entire passage of a model Francis hydraulic turbine is simulated using transition shear-stress transport turbulence and verified with experimental data. Pressure oscillations original runner cone, an extended cone grooves, round-top are analysed under five operating conditions. The computational results show that (1) design can change distribution pattern vortex rope in draft tube narrow zone special pressure oscillation; (2) dominant...
12-O-tetradecanoylphorbol-13-acetate (TPA) activates multiple signaling pathways, alters gene expression and causes leukemic cell differentiation. How TPA-induced genes contribute to differentiation remains elusive. We noticed that chromosome 7 open reading frame 41 (C7ORF41) was a TPA-responsive its upregulation concurred with human megakaryocyte In K562 cells, ectopic of C7ORF41 significantly increased CD61 expression, enhanced ERK JNK signaling, upregulated RUNX1 FLI1, whereas knockdown...
GATA1 mutations are tightly associated with transient myeloproliferative disorder (TMD) and acute megakaryoblstic leukemia (AMKL) in children Down syndrome. Numerous genes altered GATA-1-deficient megakaryocytes, which may contribute to the hyperproliferation abnormal terminal differentiation of these malignant cells. In this study, we demonstrate that Pstpip2 is a GATA-1-repressed gene controls megakaryopoiesis. Ectopic expression PSTPIP2 impaired megakaryocytic as evidenced by decrease...
Background: HSCs are the main stromal cells in process of liver fibrosis and accelerate HCC progression. Previous studies determined that highly expressed exonuclease 1 (EXO1) increases malignant behavior is closely related to cirrhosis. This study aimed explore roles mechanisms EXO1 development cirrhosis HCC. Methods: We fully demonstrated expression was positively correlated with cirrhotic by combining bioinformatics, hepatic mouse models, human tissues. The role a murine model induced...