A5018854769- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Drug Solubulity and Delivery Systems
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Traditional Chinese Medicine Analysis
- Advanced Drug Delivery Systems
- Alkaloids: synthesis and pharmacology
- Drug Transport and Resistance Mechanisms
- Healthcare Policy and Management
- Oil and Gas Production Techniques
- Adaptive Control of Nonlinear Systems
- Hydraulic and Pneumatic Systems
- Quinazolinone synthesis and applications
- Advanced Statistical Methods and Models
- Medicinal Plant Pharmacodynamics Research
- Cancer Treatment and Pharmacology
- Phytochemistry and Bioactivity Studies
- Infrastructure Maintenance and Monitoring
- Plant-based Medicinal Research
- Phytochemistry and biological activity of medicinal plants
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects of Medicinal Plants
Tianjin University of Traditional Chinese Medicine
2016-2025
Tianjin University
2024
Wuhan Ship Development & Design Institute
2020-2021
Capital Medical University
2020
Sichuan University
2018
Shenyang Pharmaceutical University
2009-2013
657 Oslo
2012
Weatherford College
2009
Immunotherapy based on the immune checkpoint blockade has emerged as most promising approach for cancer therapy. However, proportion of colorectal patients who benefit from immunotherapy is small due to immunosuppressive tumor microenvironment. Hence, combination an ideal strategy overcome this limitation. In study, we developed a novel CSF-1R (colony-stimulating factor 1 receptor) inhibitor (PLX3397), oncolytic viruses, and anti-PD-1 antibody. Our results demonstrated that triple treatment...
Schisandra chinensis (known in Chinese as WuWeiZi, WWZ) has observable effects such astringing the lung to stop coughs, arresting sweating, preserving semen and preventing diarrhea. The major components of WWZ include lignans, triterpenoids, organic acids fatty acids. In this paper, a reliable method for rapid identification multiple by their characteristic fragments neutral losses using UPLC-Q-TOF/MS technology was developed. After review literature some reference experiments, fragmentation...
Rhubarb, as a traditional Chinese medicine, is the preferred drug for treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism vivo still unclear.In this study, chemical components were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology. The metabolic biomarkers obtained through metabolomics technology related to rhubarb-induced hepatotoxicity. Furthermore, potential targets...
For counterfactual policy evaluation, it is important to ensure that treatment parameters are relevant policies in question. This especially challenging under unobserved heterogeneity, as well featured the definition of local average effect (LATE). Being intrinsically local, LATE known lack external validity environments. paper investigates possibility extrapolating effects different settings when instrumental variables can be only binary. We propose a novel framework systematically...
Berberine chloride (BBR) is a plant alkaloid that has been used for centuries treatment of inflammation, dysentery, and liver diseases. It poorly absorbed from the gastrointestinal (GI) tract its various clinical uses are limited because poor bioavailability. The object present study was to investigate absorption enhancing effect chitosan on BBR. Mixtures BBR were prepared enhancement investigated in rats. results showed dose-dependent produced by chitosan. Formulations containing 0.5%,...
Objective We investigated the effects of mindfulness-based cognitive therapy on insomnia (MBCT-I) in breast cancer survivors. Methods In total, 136 participants were allocated randomly to a MBCT-I group or waitlist control (WLC) group. Indicators and mindfulness evaluated using Insomnia Severity Index, actigraphy Five Facet Mindfulness Questionnaire. Data collected at baseline (T1), post-intervention (T2), 3-month follow-up (T3) 6-month (T4) time points. Results severity decreased...
Abstract Bupleuri radix and liquorice are commonly used as a hepatoprotectants. Their main effective ingredients triterpenoid saponins. It is known that the saponins in not only promote metabolism of sugar lipids but also have anti‐inflammatory functions hepatoprotective effect. However, complexity these compounds results difficulty studying their pharmacodynamics mechanism. In this study, glycosides were components identified selected research object. First, mass spectrometry information...
Abstract Introduction Alismatis Rhizoma (AR) has been widely used to treat various diseases. Its complex chemical composition caused certain difficulties in the analysis of this traditional Chinese medicine. Therefore, it is necessary establish a method for rapid classification and identification constituents AR. Objective This article describes major triterpenoids Methodology The samples were analysed by ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry...
Akt, a crucial protein involved in variety of signaling pathways cancer, acts as an important regulator survival hepatocellular carcinoma (HCC), and provides curative option for the related drugs development. We have found active phenanthroindolizidine alkaloid, (13aR,14R)-9,11,12,13,13a,14-hexahydro-3,6,7-trimethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinolin-14-ol (HTBPI), is promising Akt inhibitor effective suppression HCC cells proliferation through stimulating apoptotic autophagic capability...
Objectives: The aim of this study was to perform a systematic preclinical evaluation norcantharidin (NCTD)-loaded intravenous lipid microspheres (NLM).
Evodia rutaecarpa (Juss.) Benth. (Rutaceae) dried ripe fruit is used for dispelling colds, soothing liver, and analgesia. Pharmacological research has proved that alkaloids are the main active ingredients of E. rutaecarpa. This study aimed to rapidly classify identify constituents by using UPLC-Q-TOF-MS coupled with diagnostic fragments. Furthermore, effects material base bioactive in vivo were examined such transitional components blood rats intragastrically given analyzed identified. In...