A5079757517- Reproductive Biology and Fertility
- TGF-β signaling in diseases
- Ovarian function and disorders
- Muscle Physiology and Disorders
- Neuroscience and Neural Engineering
- Graphene and Nanomaterials Applications
- Conducting polymers and applications
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- Ion channel regulation and function
- Effects and risks of endocrine disrupting chemicals
- Connective Tissue Growth Factor Research
- Bone Tissue Engineering Materials
- Reproductive Physiology in Livestock
- Antibiotic Resistance in Bacteria
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- GDF15 and Related Biomarkers
- Drug-Induced Adverse Reactions
- Oral microbiology and periodontitis research
- Growth Hormone and Insulin-like Growth Factors
- Scientific and Engineering Research Topics
- Parathyroid Disorders and Treatments
- Immune Response and Inflammation
- Cardiomyopathy and Myosin Studies
Air Force Medical University
2024
Xijing Hospital
2024
First Affiliated Hospital of Zhengzhou University
2022-2023
Harbin Medical University
2021-2023
First Affiliated Hospital of Harbin Medical University
2021-2023
Renji Hospital
2016-2017
Shanghai Jiao Tong University
2016-2017
Medical University of Vienna
2010-2013
Close relationship between polycystic ovary syndrome (PCOS) and bisphenol A (BPA) has drawn much attention in recent years, while the underlying mechanisms are poorly understood. In our study, we aim to detect BPA concentration follicular fluid investigate its effect on estradiol synthesis human granulosa cells from PCOS non-PCOS patients. Follicular were collected women who underwent controlled ovarian stimulation for vitro fertilization or intracytoplasmic sperm injection. patients (440.50...
Background Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is associated with severe cardiac complications including cardiomyopathy and arrhythmias. Recent research suggests that impaired voltage-gated ion channels dystrophic cardiomyocytes accompany pathology. It is, however, unknown if channel defects are primary effects of gene mutations, or secondary developing Methodology/Principal Findings To address this question, we first investigated sodium impairments...
Duchenne muscular dystrophy (DMD), induced by mutations in the gene encoding for cytoskeletal protein dystrophin, is an inherited disease characterized progressive muscle weakness. Besides relatively well skeletal degenerative processes, DMD also associated with cardiac complications. These include cardiomyopathy development and arrhythmias. The current understanding of pathomechanisms heart very limited, but recent research indicates that dysfunctional ion channels dystrophic cardiomyocytes...
The proinflammatory cytokine interleukin-1β (IL-1β) may be involved in several ovulation-associated events, such as protease synthesis, prostaglandin production, and steroidogenesis granulosa cells. However, the exact effect of IL-1β on progesterone synthesis cells underlying mechanism remain unclear. By using cultured granulosa-lutein collected from women undergoing vitro fertilization or intracytoplasmic sperm injection, we found that upregulated steroidogenic acute regulatory protein...
Abstract Background Growth differentiation factor-11 (GDF-11), also known as bone morphogenetic protein-11, belongs to the transforming growth factor-beta superfamily. GDF-11 was first identified an important regulator during embryonic development. Increasing evidence has demonstrated that regulates development of various organs and its aberrant expressions are associated with risk cardiovascular diseases cancers. Extravillous trophoblast (EVT) cells invasion is a critical event for placenta...
Abstract Background Growth differentiation factor-11 (GDF-11) belongs to the transforming growth factor-β (TGF-β) superfamily. To date, expression of GDF-11 in ovary and its role regulating ovarian function are completely unknown. Ovarian granulosa cell-mediated steroidogenesis plays a pivotal maintaining normal female reproductive function. GDF-8 share high sequence similarity exhibit many similar features functions. Steroidogenic acute regulatory protein (StAR) regulates rate-limiting step...
Anti-inflammation and bone regeneration are the two major goals of periodontal therapy. We have demonstrated that chitosan (CS)/polyvinyl alcohol (PVA)/graphene oxide (GO)/astaxanthin (ASTA) nanofibers membranes prepared by electrospinning had favorable micro-morphology, good mechanical properties, no cytotoxicity. In this study, CS/PVA/GO/ASTA were to modulate both inflammatory response osteogenic induction in vitro study. When co-cultured with RAW264.7 cells, glycoprotein nonmetastatic...
Abstract Background Ovarian hyperstimulation syndrome (OHSS) is a serious complication during in vitro fertilization (IVF) treatment. The upregulation of ovarian transforming growth factor-beta 1 (TGF-β1) involved the development OHSS. secreted protein acidic and rich cysteine (SPARC) multifunctional matricellular glycoprotein. Although regulatory effects TGF-β1 on SPARC expression have been reported, whether regulates human ovary remains unknown. In addition, role pathogenesis OHSS unclear....
Abstract Ovarian hyperstimulation syndrome (OHSS) is a life-threatening and potentially fatal complication during in vitro fertilization treatment. The levels of transforming growth factor-β1 (TGF-β1) are upregulated human follicular fluid granulosa-lutein cells (hGL) OHSS patients could contribute to the development by downregulating steroidogenic acute regulatory protein (StAR) expression. However, whether same true for other two members TGF-β family, TGF-β2 -β3, remains unknown. We showed...
ABSTRACT Multidrug-resistant Klebsiella pneumoniae strains, especially carbapenem-resistant K. , have become a rapidly emerging crisis worldwide, greatly limiting current therapeutic options and posing new challenges to infection management. Therefore, it is imperative develop novel effective biological agents for the treatment of multidrug-resistant infections. Platelets play an important role in development inflammation immune responses. The main component responsible platelet...