A5100403241- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Sarcoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tumors and Oncological Cases
- Colorectal and Anal Carcinomas
- Digestive system and related health
- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Vascular Tumors and Angiosarcomas
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Wnt/β-catenin signaling in development and cancer
- Chronic Lymphocytic Leukemia Research
- Vitamin D Research Studies
- Colorectal Cancer Screening and Detection
Affiliated Hospital of Qingdao University
2023-2025
Qingdao University
2023-2025
Peking University Cancer Hospital
2020-2024
Peking University
2020-2024
Capital Medical University
2024
Jining Medical University
2023
University of Electronic Science and Technology of China
2022
Shanxi Academy of Medical Sciences
2022
The First People's Hospital of Tianmen
2019
Zhongshan Hospital of Xiamen University
2016
<title>Abstract</title> Hypopharyngeal squamous cell carcinoma (HPSCC), one of the most aggressive malignancies in upper aerodigestive tract, is characterized by poor prognosis and low overall survival rates. While alcohol consumption constitutes a key risk factor driving its progression, molecular mechanisms underlying HPSCC adaptation to alcohol-induced oxidative stress remain unclear. This study elucidates role CHCHD2 mediating alcohol-driven epithelial-mesenchymal transition (EMT)...
Heterogeneity with respect to recurrence and survival in high-risk stage II colon cancer patients still exists, further classification is urgently required. This study aimed ascertain the prognostic value of DNA ploidy, stroma-tumour fraction nucleotyping prognosis cancer.A total 188 received radical surgery Peking University Cancer Hospital, from 2009 2015. Status mismatch repair proteins tumours was analysed using immunohistochemistry. were estimated by automated digital imaging...
Previous genetic studies on colorectal carcinomas (CRC) have identified multiple somatic mutations in four candidate pathways (TGF-β, Wnt, P53 and RTK-RAS pathways) populations of European ancestry. However, it is under-studied whether other harbor different sets hot-spot these oncogenes. In this study, to evaluate the mutational spectrum novel mutations, we assessed 41 pairs tumor-stroma tissues from Chinese patients with CRC, including 29 colon 12 rectal carcinomas. We designed Illumina...
Octamer-binding transcription factor 4 (Oct4) is closely related to the occurrence and development of cancer. In present study, we paid a special interest in exploring effect Oct4 on colon cancer (CC) proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) its molecular mechanism. Immunohistochemistry (IHC) was used detect expression level tissue patients with overexpression vector pcDNA-Oct4 stably express human cells HT29 SW480. Cell counting kit-8 (CCK-8) assay cell...
Abstract Background The aberrant expression of BRIP1 was associated with several cancers; however, the panoramic picture in human tumors remains unclear. This study aims to explore pan-cancerous across 33 cancers. Methods Based on data from TCGA and GTEx, a series bioinformatic analyses were applied systematically genetic landscape biologic function tumors. Results We observed prognosis-related differential expressions between various carcinomas corresponding normal tissues. “Basal...
Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays role in apoptosis induction. However, the precise impact of LKB1 expression on gastric cancer (GC) progression and its correlation with survivin p53 GC have not yet been elucidated.The aim this study was to explore significance GC.In study, detected adjacent paracancerous tissues from 150 patients through immunohistochemical (IHC) staining. The relationship between clinical pathological factors analyzed, alongside...
<title>Abstract</title> <bold>Purpose</bold> As a rare subpopulation of colorectal cancer (CRC), signet ring cell carcinoma (SRCC) has poor prognosis. The prognostic role DNA mismatch repair (MMR) been seldom studied. Thus, to analyze the effect MMR status on survival outcomes in SRCC patients, we conducted this retrospective study. <bold>Method</bold> was performed 114 patients <italic>via</italic> IHC. Prognostic clinicopathologic parameters deficient or proficient were compared by...
Abstract Background： Polymorphic adenoma-like protein 2 (PLAGL2), a zinc finger protein, has been linked to the advancement of serval-type malignancies. However, relevance PLAGL2 prognosis and regulatory networks different cancers remains unclear. Methods： The expression was explored through Oncomine, TIMER SangerBox websites. relationship between in various analyzed Kaplan-Meier Plotter database PrognoScan databases. several immunological molecular subtypes human cancer evaluated TISIDB...
Objective To investigate the expressions of survivin and Ki67 in cutaneous extranodal NK/T-cell lymphoma,nasal type their significance.Methods Clinical data laboratory test results were collected from 15 cases with skin lesions as initial manifestation.Immunohistochemical SP method was used to measure expression tissue sections these patients.To determine percentage survivin-or Ki67-positive cells,200 tumor cells counted a high power field (HPF) 5 HPFs observed 1 section.Results There 10...
Abstract Background Polymorphic adenoma-like protein 2 (PLAGL2), a zinc finger protein, has been linked to the advancement of serval-type malignancies. However, relevance PLAGL2 prognosis and regulatory networks different cancers remains unclear. Methods The expression was explored through Oncomine, TIMER SangerBox websites. relationship between in various analyzed Kaplan-Meier Plotter database PrognoScan databases. several immunological molecular subtypes human cancer evaluated TISIDB...