A5090468585- Coronary Interventions and Diagnostics
- Advanced Numerical Methods in Computational Mathematics
- Computational Fluid Dynamics and Aerodynamics
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Fluid Dynamics and Turbulent Flows
- Fluid Dynamics and Vibration Analysis
- Advanced biosensing and bioanalysis techniques
- Lattice Boltzmann Simulation Studies
- Model Reduction and Neural Networks
- Cardiac Imaging and Diagnostics
- Wind and Air Flow Studies
- Nasal Surgery and Airway Studies
- Elasticity and Material Modeling
- Obstructive Sleep Apnea Research
- Biosensors and Analytical Detection
- Aortic aneurysm repair treatments
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Cloud Computing and Resource Management
- Real-time simulation and control systems
- Cancer Genomics and Diagnostics
- Nanopore and Nanochannel Transport Studies
- Cardiovascular Function and Risk Factors
- Aerodynamics and Fluid Dynamics Research
Shenzhen Institutes of Advanced Technology
2016-2025
Chinese Academy of Sciences
2014-2025
Shanxi Academy of Medical Sciences
2020-2025
Shanxi Medical University
2022-2025
King Abdullah University of Science and Technology
2020
University of Macau
2020
Hubei University of Technology
2014
Air Force Medical University
2008
Shanghai Children's Medical Center
2008
KU Leuven
2003
A rapid and convenient homogeneous aptamer sensor with high sensitivity is highly desirable for the electrochemical detection of tumor biomarkers. In this work, a demonstrated based on two-dimensional (2D) nanocomposite probe nanochannel modified electrode, which can realize sensitive carcinoembryonic antigen (CEA). Using π-π stacking electrostatic interaction, CEA (Apt) cationic redox (hexaammineruthenium(III), Ru(NH3)63+) are co-loaded graphite oxide (GO), leading to 2D...
The fractional pressure ratio is introduced to quantitatively assess the hemodynamic significance of severe intracranial stenosis. A computational fluid dynamics-based method proposed non-invasively compute FPRCFD and compared against measured by an invasive technique. Eleven patients with stenosis considered for endovascular intervention were recruited procedure was performed measure distal aortic ( Pd Pa). calculated as [Formula: see text]. computed tomography angiography used reconstruct...
Timely, convenient, and efficient detection of carbohydrate antigen 15-3 (CA15-3) levels in serum holds significant importance early screening, diagnostic assistance prognosis prediction breast cancer. The development convenient electrochemical aptasensors with immobilized redox probes for label-free CA15-3 is highly desirable. In this work, a bipolar silica nanochannel array film (bp-SNA) two distinct functional domains including nanochannels an outer surface was employed the immobilization...
Human facial transplantation, a form of composite tissue allotransplantation, has now become clinical reality. We carried out the world's second partial transplantation in April 2006. reviewed some issues associated with especially focusing on individual who underwent transplant our department. discussed surgical indications, techniques, risks versus benefits, informed consent and psychosocial, societal financial transplantation. In opinion, progresses or full is becoming timely effective...
Carcinoembryonic antigen (CEA) is an important tumor biomarker for the early clinical diagnosis of various cancers, and, therefore, accurate and sensitive quantitative determination CEA vital significance. In this study, we demonstrated in situ growth Au nanoparticles (AuNPs) on nitrogen-doped graphene quantum dots (N-GQDs) decorated reduced oxide (rGO) nanocomposites by using simple drop-coating electrochemical deposition methods. N-GQDs@rGO can be formed through π–π stacking interaction...
Background In intracranial atherosclerotic stenosis (ICAS), low fractional flow (FF) may indicate hemodynamic significance. Objective To investigate, using simulation models, whether invasive measurement could accurately reflect ‘true’ FF, when the catheter/pressure wire might disturb focal during measurement. Methods We recruited 5 patients with high-grade, symptomatic M1 middle cerebral artery in three-dimensional rotational angiography (3DRA). each case, stenotic severity was manually...
ABSTRACT OCT4 plays a crucial role in the DNA damage response(DDR) mechanism, whereas cisplatin (CDDP) acts as an anti‐tumor agent by inducing DDR. This study aimed to investigate of regulating methyltransferase 1 (DNMT1) CDDP‐treated gastric cancer (GC). A dual‐luciferase reporter assay was performed detect relationship between DNMT1 and OCT4. Human GC cell lines HGC‐27 MGC‐803 were transfected with siRNA–OCT4 or ov‐DNMT1 construct interfering lines; CDDP 0, 2.5, 5, 10, 20 µM used treat...
Leptomeningeal collateral (LMC) status governs the prognosis of large artery occlusive stroke, although factors determining LMC are not fully elucidated. The aim was to investigate metrics affecting in such patients by using computational fluid dynamics (CFD) models based on computed tomography angiography (CTA).In this cross-sectional study, with recent ischaemic stroke or transient attack attributed atherosclerotic M1 middle cerebral (MCA) stenosis (50%-99%) were recruited. Demographic,...
Noninvasive fractional flow reserve (FFR) has been extensively studied and gained clinical recognition. However, the effect of an interventional catheter a pressure wire in arteries on noninvasive FFR was not considered previous studies. We provide quantitative analysis how can affect estimation using computational fluid dynamics (CFD) techniques.Six patients are studied. calibrate our CFD model with patient-specific conditions so that matches measured by wire. Then, we numerically remove...
Accurate and fast prediction of the hemodynamics artificial pump-lung is critical in design process. In this study, a comprehensive computational framework, including sliding mesh method, coupled free flow porous media model, hemolysis k−ω shear stress transport turbulence solution algorithms, introduced to accurately predict velocity field, pressure heads, hemolysis. The framework used do shape an on supercomputer. High-resolution simulation results are obtained analyzed, parallel...
Summary We present a parallel fully implicit algorithm for the large eddy simulation (LES) of incompressible turbulent flows on unstructured meshes in three dimensions. The LES governing equations are discretized by stabilized Galerkin finite element method space and an second‐order backward differentiation scheme time. To efficiently solve resulting nonlinear systems, we highly Newton‐Krylov‐Schwarz based domain decomposition techniques. Analytic Jacobian is applied order to obtain best...
We develop a multilayer nonlinear elimination preconditioned inexact Newton method for algebraic system of equations, and target application is the three-dimensional steady-state incompressible Navier--Stokes equations at high Reynolds numbers. Nonlinear problems are often more difficult to solve than time-dependent because Jacobian matrix less diagonally dominant, good initial guess from previous time step not available. For such problems, Newton-like methods may suffer slow convergence or...
Octamer-binding transcription factor 4 (Oct4) is closely related to the occurrence and development of cancer. In present study, we paid a special interest in exploring effect Oct4 on colon cancer (CC) proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) its molecular mechanism. Immunohistochemistry (IHC) was used detect expression level tissue patients with overexpression vector pcDNA-Oct4 stably express human cells HT29 SW480. Cell counting kit-8 (CCK-8) assay cell...
In vivo studies on association between wall shear stress (WSS) and intracranial plaque are deficient. Based the three-dimensional T1-weighted high-resolution magnetic resonance imaging (3DT1 HR-MRI) data of patients with low-grade stenotic (<50%) atherosclerotic middle cerebral artery (MCA) subjects normal MCA, we built a reconstructed WSS model by computational fluid dynamics (CFD) technique. Three-dimensional registration CFD to HR-MRI was performed projections based resolution thickness...
Convenient and sensitive detection of tumor biomarkers is crucial for the early diagnosis treatment cancer. Herein, we present a probe-integrated label-free electrochemical immunosensor based on binary nanocarbon composites surface-immobilized methylene blue (MB) redox probes carbohydrate antigen 199 (CA19-9), which closely associated with gastric malignancies. Nanocarbon consisting electrochemically reduced graphene oxides carbon nanotubes (ErGO-CNT) are electrodeposited onto an indium tin...
Gallbladder torsion is a rare acute abdominal condition that requires emergency surgery. It occurs more commonly in elderly people and women the adult population. Diagnosis challenge as non-specific symptoms signs have been reported on ultrasonography, computed tomography magnetic resonance imaging. Prompt cholecystectomy can decrease mortality morbidity of perforation due to gallbladder torsion.An 82-year-old woman with upper-right quadrant pain associated nausea vomiting was diagnosed...