A5101438577- Esophageal Cancer Research and Treatment
- Dialysis and Renal Disease Management
- Advanced Memory and Neural Computing
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- interferon and immune responses
- Advancements in Semiconductor Devices and Circuit Design
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
- Ferroelectric and Negative Capacitance Devices
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Integrated Circuits and Semiconductor Failure Analysis
- Concrete and Cement Materials Research
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Seed and Plant Biochemistry
- Tannin, Tannase and Anticancer Activities
- Acute Kidney Injury Research
- Tea Polyphenols and Effects
- Gout, Hyperuricemia, Uric Acid
- Whipple's Disease and Interleukins
- Macrophage Migration Inhibitory Factor
- Semiconductor materials and devices
China Medical University
2019-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Zhengzhou University
2015-2023
First Affiliated Hospital of Zhengzhou University
2023
Henan Provincial Center for Disease Control and Prevention
2023
Henan Cancer Hospital
2015-2022
Tianjin Medical University
2022
Second Hospital of Tianjin Medical University
2022
Henan Provincial People's Hospital
2020-2021
Radiotherapy is an effective treatment for esophageal cancer; however, tumor resistance to radiation remains a major biological problem. The present study aimed investigate whether inhibition of autophagy may decrease overall radiation. effects the inhibitor 3‑methyladenine (3‑MA) on radiosensitivity were tested in EC9706 human squamous cell carcinoma line by colony formation assay. Furthermore, synergistic cytotoxic 3‑MA and assessed xenograft model nude mice. Mechanistic studies performed...
Cisplatin- (CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin. Several sirtuin (SIRT) family proteins are involved in AKI, while roles Sirt5 cisplatin-induced AKI remain unknown. In present study, we characterized role and mechanism apoptosis using human 2 (HK-2) cell line. CDDP treatment decreased expression HK-2 cells a dose-dependent manner. addition, overexpression enhanced metabolic activity CDDP-treated siRNA attenuated it. Forced inhibited CDDP-induced...
Nuclear-located covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is a determining factor for HBV persistence and the key obstacle cure chronic B. However, it remains unclear whether how host immune system senses cccDNA its biological consequences.Here, we demonstrated that interferon-inducible protein 16 (IFI16) could serve as unique innate sensor to recognize bind in hepatic nuclei, leading inhibition transcription replication. Mechanistically, our data showed IFI16...
We proposed to compare the outcomes of first‐line epidermal growth factor receptor–tyrosine kinase inhibitor ( EGFR ‐ TKI ) alone with plus whole‐brain radiotherapy WBRT for treatment brain metastases BM in patients ‐mutated lung adenocarcinoma. A total 1665 were screened from 2008 2014, and 132 enrolled our study. Among patients, 72 (54.5%) harbored a deletion exon 19, 97 (73.5%) showed multiple intracranial lesions, 67 (50.8%) had asymptomatic . Seventy‐nine (59.8%) treated alone, 53...
The imbalance of T helper (Th) 17/T regulatory (Treg) is involved in chronic heart failure (HF). enzyme lysyl oxidase (LOX) contributes to myocardial fibrosis. This study was designed decipher the mechanism Th17/Treg on LOX expression and validate whether regulates fibrosis by modulating expression.Human cardiac fibroblasts (HCFs) were treated with angiotensin II (Ang II) co-cultured Th17 cells Tregs which polarized from control naïve CD4+ cells. adoptively transferred into abdominal aortic...
Background Accumulating evidence indicates that mitophagy is crucial for the development of diabetic nephropathy (DN). However, little known about key genes involved. The present study to identify potential mitophagy-related (MRGs) in DN. Methods Five datasets were obtained from Gene Expression Omnibus (GEO) database and split into training validation set. Then differentially expressed MRGs screened further analyzed GO KEGG enrichment. Next, three algorithms (SVM-RFE, LASSO RF) used hub...
Background Nonalcoholic fatty liver disease (NAFLD) has emerged as a significant global health concern, with advanced fibrosis increasing mortality risks. Despite the abundance of dietary guidelines for managing NAFLD, precise impact diet quality on among individuals remains elusive. This study aims to explore influence five indexes NAFLD patients and patients. Methods utilized data from National Health Nutrition Examination Survey (NHANES) spanning 2005 2018 assess based Alternate...
Cholelithiasis are a condition that creates an economic and medical burden on society, women more susceptible to gallbladder stones. However, the effect of smoking development gallstones remains controversial. No studies, our knowledge, have discussed association between smoke exposure separately in men women. We evaluated both sexes. conducted cross-sectional analysis using data obtained from National Health Nutrition Examination Survey 2017 March 2020. The was limited individuals aged ≥ 20...
Abstract MicroRNA‐134‐5p (MiR‐134‐5p) has been proposed as a promising novel biomarker for the diagnosis of acute myocardial infarction (AMI). However, biological role miR‐134‐5p in ischemic cardiomyocytes little disclosed yet. Expression and X‐linked inhibitor apoptosis protein (XIAP) was detected using RT‐qPCR western blot. Oxidative stress cell were determined by enzyme‐linked immunosorbent assays, 3‐(4, 5‐dimethylthiazole‐2‐y1)‐2, 5‐biphenyl tetrazolium bromide assay, flow cytometry,...
Aim: To evaluate the prognostic value of pretreatment nutritional index (PNI) in nasopharyngeal carcinoma (NPC) patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy. Materials & methods: We conducted a retrospective study on PNI NPC patients. A new marker was explored based risk stratification and age. Results: age were two independent factors for overall survival (OS) progression free besides node stage clinical stage. Low high (LPNI–HAge) identified as an...
Epidermal growth factor receptor tyrosine kinases inhibitors (EGFR-TKIs) are currently recognized as the standard treatment for advanced non-small cell lung cancer (NSCLC) patients with EGFR mutations. Clinically found different mutational status have prognosis.A retrospective cohort study was performed to explore relationship between mutations and abundance patient survival by using data from Affiliated Cancer Hospital of Zhengzhou University January 2013 November 2016. All involved in...
Prostate cancer is one of the most common malignant tumors male genitourinary system. Fibroblast activation protein alpha (FAP-α) overexpression has been shown to occur in a wide range tumors. However, specific mechanism FAP-α development prostate not reported.In this study, real-time quantitative PCR (qRT-PCR) was used detect relative expression mRNA cell lines (PC-3, LNCaP, and DU145) human normal epithelial line RWPE-1. Small interfering RNA (siRNA) targeting vectors expressing exogenous...
Memristor technology is regarded as a potential solution to the memory bottleneck in Von Neumann Architecture by putting storage and computation integrated same physical location. In this paper, we proposed nonvolatile exclusive-OR (XOR) logic gate with 5 memristors, which can execute operation single step. Moreover, based on XOR gate, full adder was presented simulated SPICE. Compared other adder, circuits have benefits of simpler architecture, higher speed lower power consumption. This...
We aimed to investigate the role of polymorphisms in IL-16 genes on susceptibility Coronary Artery Disease (CAD).A total 260 CAD cases and 281 health controls were collected between January 2008 November 2011. Genotyping rs8034928, rs3848180, rs1131445, rs4778889 rs11556218 was conducted by polymerase chain reaction (PCR) matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry technologies.The frequencies rs8034928 C allele rs3848180 G group significantly...
Background: Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. LncRNA OIP5 antisense RNA 1 (OIP5-AS1) has found to be associated with development In this study, we further investigated molecular basis OIP5-AS1 atherosclerosis pathogenesis. Methods: Oxidative low-density lipoprotein (ox-LDL) was used treat human umbilical vein endothelial cells (HUVECs). The levels OIP5-AS1, miR-135a-5p, and Krüppel-like factor 5 (KLF5) were detected by quantitative...
A newly designed crosslinked polyaniline (CPAN) was developed and preliminarily used to fabricate a sensor for determination of ascorbic acid (AA). The nanostructured copolymer confirmed through surface morphology studies (SEM). amperometric response electrodes toward AA based on is far more than that linear (LPAN), which exhibits improved electrocatalytic oxidation AA. range the promising from 5.0 × 10−6 1.13 10−2 M with lower detection limit 1.67 (S/N = 3) as well good selectivity,...
In this paper, we proposed a novel design of binary content addressable memory (CAM) based on 1 transistor and 2 memristors (1 T2M) structures. each cell, in series that stored complementary resistance states construct the part is used as access device. The CAM has simple structure, nanosecond search delays low power consumption. correctness effectiveness verified by Hspice. Influences different features like counts mismatch bits, sizes word length are also considered.
A 55-year-old woman underwent simultaneous liver-kidney transplantation because of polycystic liver and kidney. Six months later, FDG PET/CT was acquired to evaluate possible lesions in the renal graft, which demonstrated abnormal F-FDG accumulation pelvic without other abnormality. The subsequent pathology examination after biopsy polymorphic posttransplant lymphoproliferative disorders.