A5001224100- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- Endometrial and Cervical Cancer Treatments
- Cancer Diagnosis and Treatment
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Effects of Radiation Exposure
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Tumors and Oncological Cases
- Bone and Joint Diseases
- Cancer therapeutics and mechanisms
- Ovarian cancer diagnosis and treatment
Sichuan Cancer Hospital
2016-2025
University of Electronic Science and Technology of China
2017-2025
Chengdu University of Technology
2023
Sun Yat-sen University
2016
Sun Yat-sen University Cancer Center
2016
To compare the performance of magnetic bead (MB) and concentrated precipitation (CP) based RT-qPCR to qualify cell free EBV DNA (cfEBV DNA) for nasopharyngeal carcinoma (NPC) in non-endemic area China. From January 2014 June 2024, a retrospective analysis 2 cohort studies on cfEBV NPC patients was conducted assess diagnostic value, positive detection rate clinical application. with CP 1 MB method 2. The quantitative measurement load higher than same plasma samples from (P < 0.001). measured...
To determine predictive factors for temporal lobe injury (TLI) in nasopharyngeal carcinoma patient (NPC) treated with intensity-modulated radiation therapy (IMRT). A total of 695 NPC cases IMRT were retrospectively analyzed. TLI was diagnosed on MRI images. Volume-dose histograms 870 evaluable lobes analyzed, and the occurrence evaluated. Receiver operating characteristic curve (ROC) Logistic regression analysis used to volume-dose parameters that predict (TLI). Univariate multivariate...
Purpose: Radiotherapy-induced oral mucositis is the most common side effect in nasopharyngeal carcinoma (NPC) patients. We aimed to evaluate efficacy and safety of Rabdosia rubescens drop pills NPC patients with radiation-induced (RTOM). Methods: The study involved 40 who were given thrice daily from start radiation therapy. monitored incidence severity pain. main outcomes measured occurrence rate mucositis, grade 3 pain assessment, changes immunological function, body weight, BMI, NRS2002,...
Immunotherapy combined with chemotherapy is currently the first-line treatment for metastatic head and neck squamous cell carcinoma (HNSCC). This study aims to evaluate whether adding metastasis-directed radiotherapy (MDRT) immunotherapy could improve survival rate of patients HNSCC. A retrospective analysis was conducted on HNSCC who developed distant metastases after curative treatment. Systemic determined by multidisciplinary team, a programmed death-1 (PD-1) inhibitor as primary...
Objective. To evaluate the efficacy and safety of Kangfuxin Solution, a pure Chinese herbal medicine, on mucositis induced by chemoradiotherapy in nasopharyngeal carcinoma patients. Methods. A randomized, parallel-group, multicenter clinical study was performed. total 240 patients were randomized to receive either Solution (test group) or compound borax gargle (control during chemoradiotherapy. Oral mucositis, upper gastrointestinal oral pain evaluated Common Terminology Criteria for Adverse...
BACKGROUND Reactivation of hepatitis B virus (HBV) is a fatal complication chemotherapy. Occult HBV infection might be reactivated in patients undergoing chemotherapy or immunosuppression. However, the mechanism reactivation induced by immunosuppression remains unclear. MATERIAL AND METHODS HepG2.2.15 cells were treated with an autophagy inducer (rapamycin), inhibitor (3-methyladenine, 3-MA), and dexamethasone. Autophagosomes observed transmission electron microscope (TEM). LC3-I, LC3-II,...
Radiation-induced brainstem necrosis (RIBN) is a late life-threatening complication that can appear after treatment in patients with nasopharyngeal carcinoma (NPC). However, the relationship between RIBN and radiation dose not still well-defined.During January 2013 December 2017, total of 1063 NPC were treated at Sichuan cancer hospital IMRT. A 479 eligible for dosimetric analysis. Dosimetric parameters RIBN, Dmax(the maximum dose), D0.1c (maximum average delivered to 0.1-cc volume), D1cc,...
// Qiao He 1, * , Wanyu Li 2, Jihua Ren 2 Yecai Huang 3 Ying 4 Qin Hu 1 Juan Chen Weixian Department of Laboratory Medicine, The Second Affiliated Hospital Chongqing Medical University, Chongqing, China and the Key Molecular Biology Infectious Diseases designated by Chinese Ministry Education, Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Diseases, These authors have contributed equally to this work Correspondence to: Chen, e-mail: yixin_xinyuan@163.com chenweixian75@163.com...
Aim: To evaluate the prognostic value of pretreatment nutritional index (PNI) in nasopharyngeal carcinoma (NPC) patients treated with neoadjuvant chemotherapy followed by concurrent chemoradiotherapy. Materials & methods: We conducted a retrospective study on PNI NPC patients. A new marker was explored based risk stratification and age. Results: age were two independent factors for overall survival (OS) progression free besides node stage clinical stage. Low high (LPNI–HAge) identified as an...
Background: Hepatoid adenocarcinoma (HAC) of the lung, a very rare tumor, has been reported metastasizing to lymph nodes and distant tissue, with poor prognosis. We report case lung HAC gingiva, which is metastasis site. Case Report: A 70-year-old, 50-pack-year, male smoker was diagnosed mass on health examination. chest CT showed in superior lobe right enlarged hilum mediastinum. Liver other digestive tumors were excluded. The confirmed be by biopsy positivity HepPar-1. Despite erlotinib...
The aim of this study was to evaluate the efficacy and safety antiulcer oral mucosal protectant-RADoralex® in prevention treatment radiation-induced reactions elicited during intensity-modulated radiation therapy (IMRT). for locally advanced nasopharyngeal carcinoma (NPC). A total 90 patients with NPC who developed post-treatment grade 1 mucositis were selected study. They randomly assigned experimental group (n = 44) treated by mouth rinsing RADoralex® radiochemotherapy control 43) sodium...
Programmed cell death-1 (PD-1) inhibitor was proven to be useful for the recurrent/metastatic head and neck squamous carcinoma (R/M HNSCC) patients. Though both PD-1 alone combination with chemotherapy showed some benefit PFS OS, survival outcome still not satisfactory. Some studies possible inhibitors radiation carcinoma, however there few concerned about synergy of concurrent chemoradiotherapy R/M HNSCC. So, we aimed explore potential effect toxicity HNSCC.We consecutively enrolled HNSCC...
Abstract In endemic areas, EBV DNA is used to guide diagnosis, detect recurrence and distant metastasis of NPC. Until now, the importance in prediction NPC has received little attention non-endemic regions. To explore prognostic value alone or combination with PNI patients from a area China. this retrospective study, 493 were enrolled. Clinical pathologic data, pre-treatment plasma DNA, laboratory tests all performed. A standard anticancer treatment was prescribed, follow up data collected....
Non-small cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. Whole-brain radiotherapy (WBRT) is one of the standard treatment strategies for NSCLC. It interesting to combine angiogenesis inhibitors such as bevacizumab radiation therapy. This study aimed explore efficacy and safety stereotactic radiosurgery (SRS) WBRT combined in metastases.A total 21 from NSCLC were treated WBRT-SRS, while 28 WBRT-SRS only. The average dose...
To determine the predictive value of preoperative inflammatory markers in hepatocellular carcinoma (HCC) prognosis after transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA).A total 161 patients HCC who underwent TACE RFA were enrolled this retrospective study. Receiver operating characteristic (ROC) curve analysis was used to decide cutoff neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), platelet-to-lymphocyte (PLR), and prognostic...
To assess the prognostic value of human papillomavirus (HPV) viral load in locally advanced cervical carcinoma treated with radical concurrent chemoradiotherapy.From January 2012 to October 2013, a total 246 patients were included this retrospective study. HPV DNA status was tested by Hybrid Capture 2 assay. Tumor size measured on T2WI. All study received cisplatin-based chemoradiotherapy intensity-modulated radiotherapy and three-dimensional brachytherapy. Survival rate calculated...
Distant metastases is the main failure mode of nasopharyngeal carcinoma. However, early prediction distant in NPC extremely challenging. Deep learning has made great progress recent years. Relying on rich data features radiomics and advantages deep image representation intelligent learning, this study intends to explore construct metachronous single-organ (MSOM) based multimodal magnetic resonance imaging.The imaging 186 patients with carcinoma before treatment were collected, gross tumor...
Preoperative noninvasive diagnosis of the benign or malignant solitary pulmonary nodule (SPN) is still important and difficult for clinical decisions treatment. This study aimed to assist in preoperative SPN using blood biomarkers.A total 286 patients were recruited this study. The serum FR+CTC, TK1, TP, TPS, ALB, Pre-ALB, ProGRP, CYFRA21-1, NSE, CA50, CA199, CA242 detected analyzed.In univariate analysis, age, CA19.9, CA242, TPS showed statistical significance a correlation with SPNs (P...
Nasopharyngeal carcinoma (NPC) is one of the most highly radiosensitive malignancies; however, some locally advanced NPC patients experienced local recurrence even though they received aggressive treatment regimens. Defining tumor volume precisely important to escalate total dose required for primary tumor. In this study, we aimed investigate feasibility and efficacy escalation guided by DW-MRI in with NPC.A 230 treated intensive modulated radiotherapy (IMRT) at Sichuan Cancer Hospital...
Previous studies have demonstrated that microRNAs (miRs) are important regulators involved in various cancers, including human glioblastoma (GBM). However, the underlying mechanism of miR‑1288 remains poorly understood, and its role GBM has not been reported. The present study confirmed expression was markedly upregulated GBM. Ectopic promoted prolife-ration, colony formation anchorage‑independent growth cells. Bioinformatics analysis coupled with western blotting luciferase report assays...