A5101688096- TGF-β signaling in diseases
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Connective Tissue Growth Factor Research
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Thyroid Cancer Diagnosis and Treatment
- Video Surveillance and Tracking Methods
- Hippo pathway signaling and YAP/TAZ
- Peroxisome Proliferator-Activated Receptors
- Biochemical Acid Research Studies
- Radiation Dose and Imaging
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Advanced Clustering Algorithms Research
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
Guiyang Medical University
2012-2025
Tianjin Medical University
2023-2025
Tianjin First Center Hospital
2023-2025
Affiliated Hospital of Guizhou Medical University
2025
Dalian Minzu University
2024
Tongji University
2024
University of Electronic Science and Technology of China
2024
Nankai University
2023
Third Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Renal tubulointerstitial fibrosis (TIF) is a major feature of diabetic nephropathy (DN). There increasing evidence demonstrating that microRNAs act as key players in the regulation autophagy and are involved DN. However, exact link among microRNAs, autophagy, TIF DN largely unknown. In this study, our results showed was observed rats together with obvious suppression. Moreover, microRNA-22 (miR-22) upregulated associated reduced expression its target gene phosphatase tensin homolog (PTEN)...
Ectopic lipid accumulation in renal tubules is closely related to the pathogenesis of diabetic kidney disease (DKD), and mitochondrial dysfunction thought play a key role accumulation. Therefore, maintaining homeostasis holds considerable promise as therapeutic strategy for treatment DKD. Here, we report that Meteorin-like (Metrnl) gene product mediates has potential We confirmed reduced expression Metrnl tubules, which was inversely correlated with DKD pathological changes human patients...
Transforming growth factor-β1 (TGF-β1) signaling has been shown to play a critical role in the development of diabetic nephropathy (DN). The nuclear transcription co-repressor Ski-related novel protein N (SnoN) is an important negative regulator TGF-β1/Smad signal transduction, and subsequent biological responses including tubule epithelial-mesenchymal transition (EMT), extracellular matrix accumulation tubulointerstitial fibrosis. Oxymatrine (OM) alkaloid extracted from Chinese herb Sophora...
Abstract Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) extensive renal tissue by facilitating partial epithelial-mesenchymal transition (EMT), increasing synthesis extracellular matrix (ECM), inhibiting degradation, inducing apoptosis parenchyma cells, and activating interstitial fibroblasts inflammatory cells. Recent studies indicated that bone morphogenetic protein-7 (BMP-7) upregulated expression...
Impaired wound healing and ulcer complications are major causes of morbidity in patients with diabetes. is associated increased inflammation poor angiogenesis diabetes patients. Here, we demonstrate that topical administration a secreted recombinant protein (Meteorin-like [Metrnl]) accelerates epithelialization mice. We observed significant increase Metrnl expression during physiological healing; however, its remained low diabetic healing. Functionally, the significantly accelerated closure...
Alantolactone (Ala), a major sesquiterpene lactone extracted from Inula helenium, exerts potent anti-tumour activities in various cancers. However, the underlying mechanism of such is still ambiguous. This study focused on evaluating effects and molecular mechanisms Ala HepG2 cells. Our results demonstrated that might inhibit cellular proliferation, induce G2/M phase arrest apoptosis Specifically, this confirmed induced by upregulating p21, downregulating cyclin A1 B1, promoting increasing...
Diabetic kidney disease is a major cause of chronic condition and the most common complication diabetes. The cellular senescence participates in process diabetic disease, but specific mechanism not yet clear. Cell cycle-related protein E2F transcription factor 1 (E2F1) member family, it plays key role damage under HG conditions. In this study, we explored whether metformin improves high-glucose-induced fibrosis renal tubular epithelial cells through cell E2F1. vivo experiments, recombinant...
Abstract Diabetic kidney disease (DKD) is one of the most serious complications diabetes mellitus (DM) and main cause end‐stage renal failure. However, pathogenesis DKD complicated. In this study, we found that miR‐124‐3p plays a key role in regulating mitochondrial function explored its possible mechanism progression by performing series vitro vivo experiments . Decreased expression was db/db mice compared to db/m mice. Moreover, down‐regulated FOXQ1 targeting mRNA 3′‐UTR NRK‐52E cells....
Amid a rising prevalence of non-alcoholic fatty liver disease (NAFLD), there is still an unmet need to better treat it. We identified secreted factor, Meteorin-like (Metrnl), with decreased levels in livers hepatic steatosis. Notably, recombinant Metrnl ameliorated steatosis NAFLD mouse models. Mechanistically, exerted dual effects by promoting triglyceride (TG) transportation the phosphatidylinositol 3-kinase (PI3K)/Akt/Sp1/cytidylyltransferase α (CCTα) axis, thereby increasing biosynthesis...
Abstract Alternative splicing (AS) regulates the diversity and level of proteome. The specificity in AS is turn regulated by RNA binding proteins, but our understanding how they act far from complete. Here we identify Angel wing (Anw) protein as a novel regulator. Loss Anw Drosophila disrupts muscle genes subsequently function. Based on mini-gene assay which its targets are co-expressed cultured cells, demonstrated orthologous regulation minigene transcripts, interaction between targets,...
Atorvastatin is a classical lipid-lowering drug. It has been reported to have renoprotective effects, such as reducing urinary protein excretion and extracellular matrix aggregation. The present study aimed investigate the specific mechanism of action in type 1 diabetic mice (T1DM) inhibiting renal tubular epithelial cell injury following treatment with high glucose fat. anti-injury involved inhibition miR-21 expression upregulation transcription its downstream gene Peroxisome...
Abstract Unveiling the mechanisms that drive pathological phenotypes of diabetic nephropathy (DN) could help develop new effective therapeutics for this ailment. Transforming growth factor‐β1 (TGF‐β1)/Smad3 signaling is aberrantly induced in DN, leading to elevated microRNA‐21 (miR‐21) expression and tissue fibrosis. Ski‐related novel protein (SnoN) negatively regulates TGF‐β pathway, but relationship between SnoN miR‐21 has not been described context DN. In study, association was...
Recent evidence suggests that a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), has anti-fibrotic effect. However, the exact mechanism of its potential remains is unclear. In this study, we investigated molecular SAHA in attenuating pulmonary fibrosis by regulating stability Smad7 paraquat (PQ)-induced lung animal model and cultured fibroblasts.Rats with paraquat-induced were fed solution (15 mg/kg) gastric gavage. Human fibroblasts (HFL1) pre-treated TGF-β1 (5 ng/mL)...
Abstract Diabetic nephropathy (DN) commonly causes end-stage renal disease (ESRD). Increasing evidence indicates that abnormal miRNA expression is tightly associated with chronic kidney (CKD). This work aimed to investigate whether miR-27a can promote the occurrence of fibrosis in DN by suppressing secreted frizzled-related protein 1 (Sfrp1) activate Wnt/β-catenin signalling. Therefore, we assessed levels miR-27a, Sfrp1, Wnt signalling components, and extracellular matrix (ECM)-related...
Renal tubular epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis (TIF) are important pathological features of diabetic nephropathy (DN). However, the regulatory mechanism underlying EMT TIF still unclear. Previous studies showed that decrease in expression phosphatase tensin homolog deleted on chromosome 10 (PTEN) was closely related to aggravation DN, but no published study how PTEN participated regulation TIF. In this study, rat proximal epithelial cells (NRK52E)...
Abstract The placenta links feto‐maternal circulation for exchanges of nutrients, gases, and metabolic wastes between the fetus mother, being essential pregnancy process maintenance. allantois mesodermal components amnion, chorion, yolk sac are derived from extraembryonic mesoderm (Ex‐Mes), however, mechanisms contributing to distinct regulation interactions epithelium during chorioallantoic fusion labyrinth formation remains unclear. Isl1 is expressed in progenitors Ex‐Mes mut mouse line...
Progressive reduction of SnoN is associated with gradual elevation TGF-β1 during diabetic nephropathy progression, suggesting to be a possible mediator signaling, potential therapeutic benefits against TGF- β1 -induced renal fibrosis. To characterize for its role in fibrosis, we assessed expression patterns response high glucose stress, and evaluated the effects upregulating on High stress induced significantly elevated SnoN, TGF-β1, Arkadia transcription; however, reduced protein levels...