A5107845780- Heat shock proteins research
- Myasthenia Gravis and Thymoma
- Reproductive Physiology in Livestock
- Vestibular and auditory disorders
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Biochemical Analysis and Sensing Techniques
- Ear Surgery and Otitis Media
- Meningioma and schwannoma management
- Pregnancy and preeclampsia studies
- melanin and skin pigmentation
- Thyroid and Parathyroid Surgery
- Text and Document Classification Technologies
- Lung Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Sirtuins and Resveratrol in Medicine
- Ginseng Biological Effects and Applications
- Ocular Surface and Contact Lens
- Peripheral Neuropathies and Disorders
- Sentiment Analysis and Opinion Mining
Xuzhou Medical College
2024-2025
Third Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Air Force Medical University
2011-2023
Henan Polytechnic University
2023
Sun Yat-sen University
2023
Ningxia Academy of Agriculture and Forestry Sciences
2020-2022
First Hospital of Jilin University
2015-2022
Jilin University
2015-2022
First Bethune Hospital of Jilin University
2022
The benefit of neoadjuvant camrelizumab plus chemotherapy for resectable stage IIIA or IIIB non-small cell lung cancer (NSCLC) remains unknown.To assess the efficacy and safety vs alone patients with NSCLC.In this randomized phase 2 clinical trial conducted at hospitals in China, aged 18 to 70 years (T3N2) NSCLC were enrolled between April 7, 2020, January 12, 2022.Patients randomly assigned receive 3 cycles (200 mg) (nab-paclitaxel, 130 mg/m2, platinum [cisplatin, 75 mg/m2; carboplatin,...
Deregulated accumulation of hypoxia-inducible factor-1α (HIF-1α) is a hallmark many solid tumors. Directly targeting HIF-1α for therapeutics challenging. Our finding that regulates secretion heat shock protein-90α (Hsp90α) cell migration raises the exciting possibility secreted Hsp90α from HIF-1α-positive tumors has better clinical outlook. Using and metastatic breast cancer cells MDA-MB-231, we show down-regulation deregulated blocks invasion cells. Reintroducing an active, but not...
MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical human malignancies. We aimed investigate the significance and prognostic value of miR-630 gastric cancer. Gastric adjacent normal specimens from 236 patients who had not received neoadjuvant chemotherapy were collected. The expression was investigated by quantitative real-time PCR assay its...
In the contemporary epoch of massive data, fuzziness labels and high dimensionality feature space are prevalent characteristics data. As a mathematical methodology for managing uncertainty, Dempster-Shafer evidence theory has found widespread applications in artificial intelligence, pattern recognition, decision analysis. However, it not garnered adequate attention label distribution learning (LDL). This paper studies selection LDL using theory. First, distance maps given, respectively....
This study examines the impact of commonly used disinfectants on hearing and structural integrity inner ear. To evaluate effects indophor, alcohol, chlorhexidine auditory function cochlear morphology in mice. Sixty-four mice were evenly divided into four groups: saline, chlorhexidine. Each mouse received a 25 μL injection designated liquid left ear, while right ear was remained untreated. Auditory brainstem response (ABR) testing performed at three intervals: before injection, 24 h...
To investigate the effects of Zexie decoction on vestibular and auditory function in guinea pigs with endolymphatic hydrolysis induced by desmopressin. Methods: Sixty were randomly evenly divided into four groups, each group has 15 pigs: normal control group, DDAVP modeling combined Decoction Double group. At 7 14 days, bone-conducted cervical evoked myogenic potential tests, brainstem responses, distortion-product otoacoustic emissions conducted to evaluate their quantitatively. After...
Video-assisted thoracoscopic surgery (VATS) has been applied to resection of small and well-encapsulated thymomas. However, few data are available regarding the application VATS in stage III thymomas.A novel subxiphoid subcostal arch approach for extended thymectomy was developed by us. From January 2014 August 2015, 14 patients with thymoma were treated using this new technique Department Thoracic Surgery, Tangdu hospital, Xi'an, China. These retrospectively reviewed analyzed.Among...
Coat colour is one of the most important economic traits sheep and mainly used for breed identification characterization. This trait determined by biochemical function, availability distribution phaeomelanin eumelanin pigments. In our study, we conducted a genome-wide association study to identify candidate genes genetic variants associated with coat in 75 Chinese Tan using ovine 600K SNP BeadChip. Accordingly, identified two significant SNPs (rs409651063 at 14.232 Mb rs408511664 14.228 Mb)...
The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers clinical veterinarians in investigating the treatment schedule. This study aims to investigate RP dairy cows by plasma metabolomics. As subjects, 10 with healthy were enrolled according strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, deregulation total bilirubin (T-bil), alkaline phosphatase (ALP), reproductive hormones shown detecting biochemical...
Chronic otitis media with effusion (COME) is a common cause of hearing loss in children and adults. Laryngopharyngeal reflux (LPR) often overlooked the clinical management COME complicated by LPR. This study aimed to investigate presence concentration trypsin pepsin middle ear (MEE), as well recurrence rate (OME) patients trypsin-/pepsin-positive MEE after acid-suppressive treatment (AST). In this study, were found patients. Follow-up results showed that OME within 1 year was significantly...
The complex etiopathology of retained placenta (RP) and hazards associated with it has made crucial for researchers clinical veterinarians to study pathogenesis, early-warning diagnosis, treatment. This aimed screen the potential prognostic markers RP in dairy cows using plasma metabolomics coupled laboratory indicators. Blood samples were collected from 260 at 21, 14, 7, 0 days before parturition 21 after parturition. Consequently, 10 healthy similar parity, body condition score, age...
Coat colour is one of the most important economic traits sheep and mainly used for breed identification characterization. This trait determined by biochemical function, availability distribution phaeomelanin eumelanin pigments. In our study, we conducted a genome-wide association study to identify candidate genes genetic variants associated with coat in 75 Chinese Tan using ovine 600K SNP BeadChip. Accordingly, identified two significant SNPs (rs409651063 at 14.232 Mb rs408511664 14.228 Mb)...
Until recently, heat shock protein 90 (Hsp90) has been mostly known as an abundant intracellular chaperone with more than 100 target proteins often involved in control of cell metabolism, survival, growth and differentiation. Hsp90 a for anti-cancer drugs, since it was found either overexpressed or overactive cancer cells. For decade, geldanamycin (GM)-derived inhibitors Hsp90s ATPase have entered various clinical trials around the world. Despite high expectations, efficacy these humans less...
In Figure 2, concentrations of the recombinant Hsp90α added to real wounds in mice were inaccurate.The correct figure and legend appear below.