A5016261403- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
- Ion Channels and Receptors
- Cancer-related molecular mechanisms research
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Connexins and lens biology
- Ear Surgery and Otitis Media
- Immune Response and Inflammation
- Spine and Intervertebral Disc Pathology
- Glaucoma and retinal disorders
- Pelvic and Acetabular Injuries
- Circular RNAs in diseases
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- IL-33, ST2, and ILC Pathways
- RNA regulation and disease
- Neurotransmitter Receptor Influence on Behavior
- Bioactive natural compounds
- Biochemical Analysis and Sensing Techniques
- Herpesvirus Infections and Treatments
- Berberine and alkaloids research
- Memory and Neural Mechanisms
Xuzhou Medical College
2015-2025
Affiliated Hospital of Xuzhou Medical College
2007-2024
Renji Hospital
2022
Second Military Medical University
2014
Changhai Hospital
2014
Chaohu Hospital of Anhui Medical University
2012
Overproduction of reactive oxygen species (ROS) and inflammation are two key pathogeneses noise-induced hearing loss (NIHL), which leads to outer hair cell (OHC) damage loss. In this work, we successfully developed ROS-responsive nanoparticles as berberine (BBR) carriers (PL-PPS/BBR) for OHC-targeted therapy NIHL: Prestin-targeting peptide 2 (PrTP2)-modified (PL-PPS/BBR), effectively accumulated in OHC areas, poly(propylene sulfide)120 (PPS120), scavenged ROS converted sulfoxide)120 a...
Abstract Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide. However, the presence blood-labyrinth barrier (BLB) on surface inner capillaries greatly hinders effectiveness systemic drugs for prevention and intervention due to low permeability, which restricts entry most drug compounds from bloodstream into tissue. Here, we report finding novel receptor, low-density lipoprotein receptor-related protein 1 (LRP1), is expressed BLB, as...
Background Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner diseases, including Meniere’s disease. We aimed evaluate the effects of on WAI OAEs. Objective This study explores potential wideband acoustic immittance (WAI) otoacoustic emissions (OAEs) for early detection changes transmission associated with vasopressin-induced endolymphatic hydrops (EH) a guinea pig model. Methods induced pigs via daily...
Abstract Noise‐induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery the inner ear. This study applied a retro‐auricular round window membrane (RWM) method bypass BLB, enabling transport of macromolecular proteins into Pigment epithelium‐derived factor (PEDF), which has anti‐inflammatory neuroprotective properties, is...
This study examines the impact of commonly used disinfectants on hearing and structural integrity inner ear. To evaluate effects indophor, alcohol, chlorhexidine auditory function cochlear morphology in mice. Sixty-four mice were evenly divided into four groups: saline, chlorhexidine. Each mouse received a 25 μL injection designated liquid left ear, while right ear was remained untreated. Auditory brainstem response (ABR) testing performed at three intervals: before injection, 24 h...
To investigate the effects of Zexie decoction on vestibular and auditory function in guinea pigs with endolymphatic hydrolysis induced by desmopressin. Methods: Sixty were randomly evenly divided into four groups, each group has 15 pigs: normal control group, DDAVP modeling combined Decoction Double group. At 7 14 days, bone-conducted cervical evoked myogenic potential tests, brainstem responses, distortion-product otoacoustic emissions conducted to evaluate their quantitatively. After...
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of sensorineural hearing loss in children. While importance CMV‑induced SNHL has been described, mechanisms underlying its pathogenesis and role inflammatory responses remain elusive. The present study established an experimental model after systemic with murine CMV (MCMV) newborn mice. Auditory brainstem were tested to evaluate at 3 weeks, expression inflammasome‑associated factors was assessed by...
The HMGA2 (high-mobility group AT-hook) protein has previously been shown as an oncoprotein, whereas ectopic expression of is found to induce growth arrest in primary cells. precise mechanisms underlying this phenomenon remain be unravelled. In the present study, we determined that was able apoptosis WI38 human We show cells expressing high level were arrested at G2/M phase and exhibited apoptotic nuclear phenotypes. Meanwhile, cleaved caspase 3 (cysteine aspartic acid-specific protease 3)...
To identify presence of inflammasome activated in mouse cochlea with sensorineural hearing loss (SNHL) caused by cytomegalovirus (CMV) infection. MCMV was injected into the right cerebral hemisphere neonatal BALB/c mice at 2000 pfu virus titers. Auditory brainstem responses (ABRs) were tested to evaluate 21 days. Histopathological studies conducted confirm localizations infected cells inner ear. Expression related factors assessed immunofluorescence, Quantitative real-time PCR and Western...
To compare the effect of thoracoscopic anterior release combined with posterior spinal fusion and posterior-only approach an all-pedicle screw construct in treatment rigid thoracic adolescent idiopathic scoliosis.From June 2001 to 2010, 63 patients who were admitted our hospital Cobb angle ≥80 degrees flexibility ≤40% enrolled study. They treated either a anterior/posterior hooks screws (group A, n=25) or alone B, n=38). The standing whole-spine anteroposterior x-ray, kyphosis (T5-T12)...
This study explores the relationship between nutritional status and oral health quality of life, self-efficacy older inpatients correlative factors.In this study, convenience sampling method was used to select 307 in southern section Renji Hospital affiliated Shanghai Jiao Tong University School Medicine from October December 2020 as main research participants. A mini assessment questionnaire assess status, Chinese version a geriatric index determine life. Self-efficacy assessed by general...
CD147, a glycosylated transmembrane protein in the immunoglobulin superfamily, is overexpressed on surfaces of various tumor cells and promotes cancer cell proliferation, invasion, metastasis. Nanobodies, characterized by small sizes, high affinities specificities, low immunogenicities, are promising diagnostic therapeutic tools. However, there few reports nanobodies that specifically target CD147. In this work, specific anti-CD147 nanobody has been successfully identified using phage...
Sensorineural hearing loss (SNHL) is the most common consequence of congenital cytomegalovirus (CMV) infection, and could result in neurological abnormalities intellectual developmental disabilities.To explore mechanism murine CMV (MCMV)-induced SNHL neonatal mice model.A repeated measures design was used.Total 72 BALB/C (36 males 36 females) were randomly divided into two groups.MCMV suspension (50% tissue culture infective dose = 10(4.15) IU/0.1 ml, 15 μl) or physiological saline...
Background Hereditary sensorineural hearing loss is a genetically heterogeneous disorder. Objectives This study was designed to explore the genetic etiology of deafness in large Chinese family with autosomal dominant, nonsyndromic, progressive (ADNSHL). Methods Whole exome sequencing and linkage analysis were performed identify pathogenic mutation. Inner ear expression Ifnlr1 investigated by immunostaining mice. ifnlr1 Morpholino knockdown Zebrafish constructed mechanism. Results We...
INTRODUCTION Posterior hemivertebra resection combined with multisegmental or bisegmental fusion has been applied successfully for congenital scoliosis. However, there are several immature bones and their growth can be influenced by long segmental in patients. monosegmental was therefore suggested treatment of scoliosis caused hemivertebra. METHODS Between June 2001 2010, 60 patients (aged 2–18 years) who underwent posterior were enrolled our study. A standing anteroposterior x-ray the whole...