A5042801750- Neuroscience and Neuropharmacology Research
- Parasites and Host Interactions
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Refrigeration and Air Conditioning Technologies
- Global Maternal and Child Health
- Radiopharmaceutical Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Heat transfer and supercritical fluids
- Advanced Thermodynamic Systems and Engines
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Parasite Biology and Host Interactions
- Click Chemistry and Applications
- Zoonotic diseases and public health
- Heat Transfer and Optimization
- Receptor Mechanisms and Signaling
- Mass Spectrometry Techniques and Applications
- Carbon dioxide utilization in catalysis
- Synthesis and Catalytic Reactions
- Advanced Measurement and Detection Methods
- Molecular Sensors and Ion Detection
- Radical Photochemical Reactions
- Pharmacological Receptor Mechanisms and Effects
Emory University
2022-2025
National Institute for Parasitic Diseases
2016-2025
National Health and Family Planning Commission
2025
Hospital for Tropical Diseases
2021-2025
Massachusetts General Hospital
2022-2024
Harvard University
2022-2024
Southwest Petroleum University
2023-2024
State Key Laboratory of Automotive Simulation and Control
2021-2024
Betta Pharmaceuticals (China)
2020-2024
Xi'an Jiaotong University
2017-2024
Different from isolated metal atoms and large nanoparticles (NPs), supported clusters (SMCs) possess distinct geometric electronic structures thus exhibit enhanced activity designated selectivity in catalysis. So far, with the development synthetic methodologies characterization techniques, SMCs fine could be constructed well-defined at atomic level. In addition, based on computational modeling of SMCs, theoretical calculations corroborated well experimental results, providing in-depth...
Herein, we report efficient single copper atom catalysts that consist of dense atomic Cu sites dispersed on a three-dimensional carbon matrix with highly enhanced mesoporous structures and improved active site accessibility (Cu-SA/NC(meso)). The ratio +1 to +2 oxidation state the in Cu-SA/NC(meso) can be controlled by varying urea content adsorption precursor, activity for ORR increases addition Cu1+ sites. optimal Cu1+-SA/NC(meso)-7 catalyst accessible exhibits superior alkaline media...
Indoleamine 2,3-dioxygenase (IDO-1) is emerging as an important new therapeutic target for the treatment of cancer, neurological disorders, and other diseases that are characterized by pathological tryptophan metabolism. However, only a few structural classes known to be IDO-1 inhibitors. In this study, natural compound tryptanthrin was discovered novel potent inhibitor screening indole-based structures. Three series 13 derivatives were synthesized, structure–activity analysis undertaken....
Abstract Metal–N–C single‐atom catalysts, mostly prepared from pyrolysis of metal‐organic precursors, are widely used in heterogeneous electrocatalysis. Since metal sites with diverse local structures coexist this type material and it is challenging to characterize the structure, a reliable structure–property relationship difficult establish. Conjugated macrocyclic complexes adsorbed on carbon support well‐defined models mimic catalysts. Metal–N 4 site four electroneutral pyridine‐type...
Cobalt phthalocyanine molecules combined with carbon materials (CoPc@NC) have been reported to exhibit prominent electrocatalytic performance toward the CO2 reduction reaction (CO2RR). However, molecular-scale insights into mechanisms regarding its high activity or Faraday efficiency remain limited due great challenge in modeling electrochemical interface. Herein, an explicit computational model inclusion of solvation and electrode potential was employed explore mechanistic nature CO2RR at...
Phosphodiesterase 4B (PDE4B) plays a critical role in cAMP hydrolysis and is highly expressed brain regions associated with neuroinflammation central nervous system (CNS) disorders. Selective PDE4B radioligands hold significant potential for elucidating disease mechanisms, such as those Parkinson's schizophrenia, enabling target occupancy measurements. In this study, we developed [ 18 F]P4B-2412, novel PDE4B-selective radioligand, evaluated its utility positron emission tomography imaging...
Phosphodiesterases (PDEs) are phosphohydrolytic enzymes responsible for degrading cyclic adenosine monophosphate (cAMP) and guanosine (cGMP), two key second messengers involved in regulating cellular functions. The PDE superfamily can be subdivided into 11 families, with PDE7 playing a crucial role the proinflammatory process, T-cell activation proliferation. As such, has emerged as potential therapeutic target treating inflammatory, immunological, neurological disorders. To date, only...
A novel rapid synthesis of indoles from N-Ts-2-alkenylanilines has been described; the reaction involves a NIS-mediated cascade C-N bond formation/aromatization, and series with various functional groups have synthesized in good to excellent yields under mild conditions without any other additives or catalysts.
The synergistic treatment of oily wastewater containing organic hazards and emulsified oils remains a big challenge for membrane separation technology. Herein, the photocatalytic membrane, which combined physical barrier catalytic oxidation-driven degradation functionality, was fabricated via anchoring nanoflower-branched CoAl-LDH@PANI Z-scheme heterojunction onto porous polyacrylonitrile mat using tannic acid as an adhesive. assembly such offered superior performance soluble dyes...
An intelligent surgical knife (iKnife) coupled with rapid evaporative ionization mass spectrometry (REIMS) was employed for the lipidomic profiling of fresh and frozen–thawed beef muscle. The data were obtained by REIMS then processed using multivariate statistical analysis methods including principal component analysis–linear discriminant (PCA–LDA) orthogonal partial least-squares (OPLS-DA). discrimination meat has been achieved, real-time identification accuracy 92–100%. Changes in...