A5027390602- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- SARS-CoV-2 detection and testing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Animal Virus Infections Studies
- Urban, Neighborhood, and Segregation Studies
- Cancer Genomics and Diagnostics
- Otolaryngology and Infectious Diseases
- Gender, Labor, and Family Dynamics
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Global Health Care Issues
- demographic modeling and climate adaptation
- Fiscal Policy and Economic Growth
- Healthcare Policy and Management
- Insurance, Mortality, Demography, Risk Management
- Cervical Cancer and HPV Research
- School Choice and Performance
- Influenza Virus Research Studies
Methodist Hospital
2014-2024
Methodist Hospital
2014-2024
Houston Methodist
2014-2023
Cornell University
2013-2023
The Ohio State University
1991-2023
Weill Cornell Medicine
2021
Center for Genomic Science
2018-2021
Texas A&M Health Science Center
2018-2020
Methodist Hospital
2011-2013
Rice University
2013
Part 1 The teaching profession at a turning point: carrots and sticks critical questions incentives an opportunity for change. 2 Who prepares to teach?: the shrinking personnel pool changing demographic profile of new licensees different specialities times. 3 becomes teacher?: national trends North Carolina matter. 4 Finding skilled teachers - hiring practices make difference: two case studies problems solutions. 5 How long do stay in teaching?: attrition is high first years race makes...
WHEN ESTIMATING REGRESSION MODELS it is very nearly always assumed that the sample random. The recent literature has begun to deal with problems which arise when estimating a regression model samples may not be most general case in one only access single nonrandom been addressed since imposing problem. starts random but considers problem of missing values for dependent variable regression. If determination are observed related unobservable error term regression, then methods such as ordinary...
Early diagnosis of gram-negative bloodstream infections, prompt identification the infecting organism, and appropriate antibiotic therapy improve patient care outcomes decrease health expenditures. In an era increasing antimicrobial resistance, methods to acquire rapidly translate critical results into timely therapies for infections are needed.To determine whether mass spectrometry technology coupled with stewardship provides a substantially improved alternative conventional laboratory...
Significance Carbapenem-resistant Klebsiella pneumoniae has emerged globally as a multidrug-resistant hospital pathogen for which there are few treatment options. Clinical isolates classified by multilocus sequence typing (ST) ST258 the most widespread. The basis success of organisms above and beyond antibiotic resistance is not known, nor it clear whether infections caused single clone. We used genome sequencing to reveal unexpected genetic diversity among (thus disproving single-clone...
Significance The results provide strong evidence of extensive SARS-CoV-2 infection white-tailed deer, a free-living wild animal species with widespread distribution across North, Central, and South America. analysis shows deer resulted from multiple spillovers humans, followed by efficient deer-to-deer transmission. discovery indicates their establishment as potential reservoir hosts for SARS-CoV-2, finding important implications the ecology, long-term persistence, evolution virus, including...
This paper shows that teachers who are paid more stay longer in teaching, with high opportunity costs, as measured by test scores and subject specialties, teaching less long than other do, salaries influence duration for lower scores. The research is based on a new longitudinal dataset providing information the career histories of 13,890 North Carolina teachers. empirical work uses generalized least squares estimation technique accommodates censored observations, time-varying covariates,...
Journal Article Prevention of Catheter-Associated Urinary Tract Infection with a Silver Oxide-Coated Catheter: Clinical and Microbiologic Correlates Get access James R. Johnson, Johnson From the Departments Medicine, University Washington, Seattle, Minnesota, Minneapolis Search for other works by this author on: Oxford Academic PubMed Google Scholar Pacita L. Roberts, Roberts Robin J. Olsen, Olsen Kris A. Moyer, Moyer Walter E. Stamm Reprints or correspondence: Dr. Stamm, Infectious Diseases...
This paper demonstrates that salaries and opportunity costs have important influences on how long teachers stay in teaching. The empirical work is based a new longitudinal dataset providing information the careers of 7800 Michigan public school teachers. generalized least squares estimation technique accommodates censored observations, time-varying covariates, fixed effects. One implication result predictions from current generation teacher supply demand models are likely to be misleading....
The identification of the molecular events responsible for strain emergence, enhanced virulence, and epidemicity has been a long-pursued goal in infectious diseases research. A recent analysis 3,615 genomes serotype M1 group Streptococcus strains (the so-called "flesh-eating" bacterium) identified recombination event that coincides with global pandemic beginning early 1980s. Here, we have shown allelic variation results from this event, which replaces chromosomal region encoding secreted...
For over a century, fundamental objective in infection biology research has been to understand the molecular processes contributing origin and perpetuation of epidemics. Divergent hypotheses have emerged concerning extent which environmental events or pathogen evolution dominates these processes. Remarkably few studies bear on this important issue. Based population pathogenomic analysis 1,200 Streptococcus pyogenes type emm89 isolates, we report that series horizontal gene transfer produced...
Newly emerged pathogens such as SARS-CoV-2 highlight the urgent need for assays that detect levels of neutralizing antibodies may be protective. We studied relationship between anti-spike ectodomain (ECD) and anti-receptor binding domain (RBD) IgG titers, virus neutralization (VN) titers generated by two different in vitro using convalescent plasma samples obtained from 68 COVID-19 patients, including 13 who donated multiple times. Only 23% (16/68) donors had been hospitalized. also 16...
Probiotic supplements are suggested to promote human health by preventing pathogen colonization. However, the mechanistic bases for their efficacy in vivo largely uncharacterized. Here using metabolomics and bacterial genetics, we show that oral probiotic Streptococcus salivarius K12 (SAL) produces salivabactin, an antibiotic effectively inhibits pathogenic pyogenes (GAS) vitro mice. prophylactic dosing with SAL enhanced GAS colonization mice ex saliva. We showed that, on co-colonization,...
Group A Streptococcus (GAS) is a versatile human pathogen causing diseases ranging from uncomplicated mucosal infections to life-threatening invasive disease. The development of human-relevant animal models GAS infection and introduction new technologies have markedly accelerated the pace discoveries related host-pathogen interactions. For example, recently investigators identified pili on cell surface learned that they are key components for adherence eukaryotic surfaces. Similarly, recent...
Single-nucleotide changes are the most common cause of natural genetic variation among members same species, but there is remarkably little information bearing on how they alter bacterial virulence. We recently discovered a single-nucleotide mutation in group A Streptococcus genome that epidemiologically associated with decreased human necrotizing fasciitis (“flesh-eating disease”). Working from this clinical observation, we find wild-type mtsR function required for to mice and nonhuman...
This study describes the design and evaluation of a portable bright-field fluorescence microscope that can be manufactured for $240 USD. The uses battery-operated LED-based flashlight as light source achieves resolution 0.8 microm at 1000x magnification in mode. We tested diagnostic capability this new instrument to identify infections caused by human pathogen, Mycobacterium tuberculosis. Sixty-four direct, decontaminated, serially diluted smears were prepared from sputa obtained 19 patients...
Group A Streptococcus (GAS) causes human infections that range in severity from pharyngitis ("strep-throat") to necrotizing fasciitis ("flesh-eating disease"). To facilitate investigation of the molecular basis host-pathogen interactions, infection models capable rapidly screening for differences GAS strain virulence are needed. this end, we developed a Galleria mellonella larvae (wax worm) model invasive and used it compare serotype M3 strains. We found severe tissue damage kills wax worms...