A5023182546- SARS-CoV-2 and COVID-19 Research
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Thyroid Cancer Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Infection Control and Ventilation
- SARS-CoV-2 detection and testing
- Machine Learning in Healthcare
- Head and Neck Anomalies
- COVID-19 Clinical Research Studies
- Ocular Disorders and Treatments
- Facial Trauma and Fracture Management
- Cystic Fibrosis Research Advances
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Cancer Mechanisms and Therapy
- Social Media in Health Education
- Telemedicine and Telehealth Implementation
Houston Methodist
2021-2023
Methodist Hospital
2021-2023
Baylor Scott & White Medical Center - Temple
2020-2023
Texas A&M Health Science Center
2023
Methodist Hospital
2021-2023
Baylor Scott & White Health
2021
The University of Texas MD Anderson Cancer Center
2015-2017
Baylor Medical Center at Garland
2017
Tehran University of Medical Sciences
2011
Iran University of Medical Sciences
2009
Measures intended to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus at start disease 2019 (COVID-19) pandemic resulted in a rapid decrease other pathogens. Herein, we describe trends pathogens major metropolitan health care system central microbiology reference laboratory before and during COVID-19 pandemic, with attention when mitigation measures were implemented relaxed. During initial lockdown period, was primary pathogen detected by multiplex...
Abstract Genetic variants of SARS-CoV-2 have repeatedly altered the course COVID-19 pandemic. Delta concern are now focus intense international attention because they causing widespread disease globally and associated with vaccine breakthrough cases. We sequenced genomes 16,965 from samples acquired March 15, 2021 through September 20, in Houston Methodist hospital system. This sample represents 91% all system patients during study period. increased rapidly late April onward to cause 99.9%...
The SARS-CoV-2 virus has caused tremendous healthcare burden worldwide. Our focus was to develop a practical and easy-to-deploy system predict the severe manifestation of disease in patients with COVID-19 an aim assist clinicians triage treatment decisions. proposed predictive algorithm is trained artificial intelligence-based network using 8,427 patient records from four systems. model provides severity risk score along likelihoods various clinical outcomes, namely ventilator use mortality....
The aim of this study was to determine the interocular differences Pentacam corneal measurements in a normal population.A retrospective analysis performed on 550 eyes 275 consecutive subjects evaluated for refractive surgery at Rassoul Akram Hospital, Iran University Medical Sciences. A Scheimpflug camera used measurements. Statistical levels difference between two eyes.One hundred and four men 171 women with mean age 29.1 +/- 7.73 years were evaluated. (range) 2.17 (zero 21) microm maximum...
Introduction: To report the results of post-traumatic enophthalmos/hypophthalmos correction with high-density porous polyethylene wedge implants in seeing eyes.Methods: This is an interventional case series 25 patients (25 eyes) enophthalmos and hypophthalmos, who underwent orbital reconstruction to correct hypophthalmos using Medpor® implant. The aim was overcorrection 1 mm comparison other eye, intra-operatively. If needed, trimming implant or adding sheets were used achieve goal. Success...
With the growing interest in total neoadjuvant treatment for locally advanced rectal adenocarcinoma (LARC) there is an urgent unmet need to identify predictive markers of response long-course concurrent chemoradiotherapy (LCRT). O6-Methylguanine (O6-MG)-DNA-methyltransferase (MGMT) gene methylation has been associated some malignancies with chemoradiotherapy. We attempted find if pathologic LCRT was MGMT promoter hypermethylation (MGMTh).Patients were identified LARC, available pre-treatment...
Abstract Genetic variants of the SARS-CoV-2 virus are substantial concern because they can detrimentally alter pandemic course and disease features in individual patients. Here we report genome sequences from 12,476 patients Houston Methodist healthcare system diagnosed January 1, 2021 through May 31, 2021. The variant designated U.K. B.1.1.7 increased rapidly caused 63%-90% all new cases area latter half May. Eleven 3,276 genomes had an E484K change spike protein. Compared with non-B.1.1.7...
Abstract Introduction Thyroid malignancy is one of the most common types cancer in developed nations. Currently, fine‐needle aspiration cytology (FNAC) practical screening test for thyroid nodules. However, cytologically indeterminate samples comprise approximately 15%–30% cases. These include cases classified as atypia undetermined significance (AUS), follicular neoplasm (FN), and suspicious (SFM). Indeterminate can be sent molecular testing more definitive classification to help guide...
e18525 Background: AML has numerous mutations that predict response to treatment and overall survival. We aimed assess various in newly diagnosed therapy related cases by NGS their association with clinicopathologic parameters. Methods: performed molecular studies on DNA extracted from bone marrow aspirate specimens 35 naïve (WHO 2008 criteria) patients (8/2013 8/2015). Entire coding sequences of 28 genes (ABL1, ASXL1, BRAF, DNMT3A, EGFR, EZH2, FLT3, GATA1, GATA2, HRAS, IDH1, IDH2, IKZF2,...
In 2016, the entity of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was proposed. This study investigated impact NIFTP nomenclature on fine-needle aspiration (FNA) evaluation nodules and clinical management, as well molecular profile NIFTP. The included 23 out 275 cases diagnosed variant papillary carcinoma from 2005 to 2015 that were reclassified NIFTP, 14 an original diagnosis 2016 2019. Information demographic characteristics, FNA diagnoses,...
e20531 Background: One-third of patients with newly diagnosed non-small cell lung cancer (NSCLC) present at an early stage. Surgical resection remains the standard care for medically fit patients. Adjuvant chemotherapy has shown benefit in stage II and III disease, but advent immune checkpoint inhibition targeted therapy, adjuvant setting is now evolving. In 2017, all hospitals Houston Methodist Hospital (HMH) system approved reflex molecular testing time diagnosis new cases NSCLC,...
Bronchus-associated lymphoid tissue (BALT) lymphomas of the lung are uncommon, and diagnosis is often delayed due to indolent clinical course. Often, adequate samples difficult obtain by bronchoscopy with transbronchial biopsy alone. This retrospective study reviewed treatment BALT lymphoma cases at our institution over course 19 years. Most patients were white, women, >50 years old; mean Charlson Comorbidity Index time was 6. Seven 12 presented solitary nodules or multiple nodules. For six...