A5082854319- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Listeria monocytogenes in Food Safety
- Essential Oils and Antimicrobial Activity
- Microbial infections and disease research
- Virus-based gene therapy research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Probiotics and Fermented Foods
- Animal Disease Management and Epidemiology
- Computational Drug Discovery Methods
- Nanocomposite Films for Food Packaging
- Meat and Animal Product Quality
- Escherichia coli research studies
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Bat Biology and Ecology Studies
- Influenza Virus Research Studies
- Bacterial biofilms and quorum sensing
- Aquaculture disease management and microbiota
- Viral Infections and Vectors
- COVID-19 Impact on Reproduction
- Insect and Pesticide Research
Pennsylvania State University
2020-2025
KIST Medical College
2024
Government Medical College
2023
Vellore Institute of Technology University
2023
Center for Disease Dynamics, Economics & Policy
2020-2023
Lewisham and Greenwich NHS Trust
2021
Florida International University
2021
Thermo Fisher Scientific (United States)
2020
University of Minnesota
2019
University of Connecticut
2015-2018
Significance The results provide strong evidence of extensive SARS-CoV-2 infection white-tailed deer, a free-living wild animal species with widespread distribution across North, Central, and South America. analysis shows deer resulted from multiple spillovers humans, followed by efficient deer-to-deer transmission. discovery indicates their establishment as potential reservoir hosts for SARS-CoV-2, finding important implications the ecology, long-term persistence, evolution virus, including...
Abstract SARS-CoV-2, the causative agent of COVID-19 pandemic, can infect a wide range mammals. Since its spread in humans, secondary host jumps SARS-CoV-2 from humans to multiple domestic and wild populations mammals have been documented. Understanding extent adaptation these animal hosts is critical for assessing threat that spillback animal-adapted into poses. We compare genomic landscapes isolated species profiling mutational biases indicative potentially different selective pressures...
The association of the receptor binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with human angiotensin-converting enzyme (hACE2) represents first required step for cellular entry. SARS-CoV-2 has continued to evolve emergence several novel variants, and amino acid changes in RBD have been implicated increased fitness potential immune evasion. Reliably predicting effect on ability interact more strongly hACE2 can help assess implications public...
Abstract SARS-CoV-2, the agent of COVID-19 pandemic, can infect a wide range mammals. Since its spread in humans, secondary host jumps SARS-CoV-2 from humans to variety domestic and wild populations mammals have been documented. The evolution different species is fundamental interest while also providing indication how may adapted human hosts soon after initial jump, time window for which there are no genome sequences available. Moreover, study circulating animals critical assess risk that...
White-tailed deer (
There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that have infected white-tailed deer, deer-to-deer transmission has occurred, indicating deer could be a wildlife reservoir source novel variants. We examined the hypothesis Omicron variant actively asymptomatically infecting free-ranging New York City. Between December 2021 February 2022, 155 on Staten Island, York, were anesthetized for gross...
Escherichia coli O157: H7 (EHEC) is a major foodborne pathogen largely transmitted to humans through the consumption of undercooked ground beef. This study investigated efficacy two food-grade, plant-derived antimicrobials, namely rutin (RT), and resveratrol (RV) with or without chitosan (CH) in enhancing EHEC inactivation hamburger patties. Further, effect aforementioned treatments on beef color lipid oxidation was analyzed. Additionally, deleterious effects these antimicrobial determined...
The COVID-19 pandemic has spurred interest in potent and thermostable SARS-CoV-2 vaccines. Here, we assess low-dose immunization with lyophilized nanoparticles decorated recombinant antigens. Spike glycoprotein or its receptor-binding domain (RBD; mouse vaccine dose, 0.1 μg) was displayed on liposomes incorporating a particle-inducing lipid, cobalt porphyrin-phospholipid (dose, 0.4 μg), along monophosphoryl lipid A 0.16 QS-21 μg). Following optimization of lyophilization conditions,...
SARS-CoV-2 continues to evolve and evade vaccine immunity, necessitating vaccines that offer broad protection across variants. Conventional mRNA face cost scalability challenges, prompting the exploration of alternative platforms like trans-amplifying (TA) advantages in safety, manufacturability, antigen dose optimization. Using consensus sequences immunodominant antigens is a promising design strategy for board cross-protection. Combining these two features, we designed evaluated TA...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to pose a significant threat public health. Notably, SARS-CoV-2 demonstrates the capacity infect various non-human animal species, including both captive and free-living animals. Earlier experimental studies revealed low susceptibility of domestic cattle (Bos taurus) ancestral B.1 lineage; however, recent findings indicate greater permissiveness Delta variant. While some detected evidence infection in Italy, Germany,...
Multi-drug resistant (MDR) Acinetobacter baumannii is a major nosocomial pathogen causing wide range of clinical conditions with significant mortality rates. A. strains are equipped multitude antibiotic resistance mechanisms, rendering them to most the currently available antibiotics. Thus, there critical need explore novel strategies for controlling in baumannii. This study investigated efficacy two food-grade, plant-derived antimicrobials (PDAs), namely trans-cinnamaldehyde (TC) and...
Abstract Millions of individuals who have recovered from SARS-CoV-2 infection may be eligible to participate in convalescent plasma donor programs, yet the optimal window for donating high neutralizing titer COVID-19 immunotherapy remains unknown. Here we studied response trajectories antibodies directed surface spike glycoprotein and vitro live virus titers (VN) 175 donors longitudinally sampled up 142 days post onset symptoms (DPO). We observed robust IgM, IgG, viral neutralization...
Abstract Introduction: The aim of this study was to identify the type and detail serious adverse events following COVID-19 vaccination in India. Materials Methods: descriptive conducted by extracting data from website Ministry Health Family Welfare, Government India https://shorturl.at/imwJY. variables analysed were types vaccines, SAEFI, thromboembolic (TE) events, neurological manifestations consistent causal association as per World Organization. Data entered into MS Excel using SPSS...
Salmonella enteritidis (SE) is a major foodborne pathogen that causes human infections largely by consumption of contaminated eggs. The external surface eggs becomes with SE from multiple sources, highlighting the need for effective egg disinfection methods. This study investigated efficacy three GRAS-status, phytochemicals, namely carvacrol (CR), eugenol (EG), and β-resorcylic acid (BR) applied as pectin or gum arabic based coating reducing on shell White-shelled eggs, spot inoculated...
Urinary tract infections (UTI) are the most common hospital-acquired in humans and caused primarily by uropathogenic Escherichia coli (UPEC). Indwelling urinary catheters become encrusted with UPEC biofilms that resistant to antibiotics, resulting chronic infections. Therefore, it is important control on reduce risk for UTIs. This study investigated efficacy of selenium inhibiting inactivating catheters. were inoculated treated 0 35 mM at 37 °C 5 days biofilm inhibition assay. In addition,...
Acinetobacter baumannii is a major nosocomial pathogen causing human infections with significant mortality rates. In most cases, are acquired through exposure to A. biofilms that persist on contaminated hospital equipment and surfaces. Thus, it imperative develop effective measures for controlling in settings. This study investigated the efficacy of octenidine dihydrochloride (OH), new generation disinfectant reducing polystyrene, stainless steel catheters. OH at 0.3% (5 mM), 0.6% (10 0.9%...
Abstract Many animal species are susceptible to SARS-CoV-2 and could potentially act as reservoirs, yet transmission of the virus in non-human free-living animals has not been documented. White-tailed deer ( Odocoileus virginianus ), predominant cervid North America, infection, experimentally infected fawns can transmit virus. To test hypothesis that may be circulating deer, we tested 283 retropharyngeal lymph node (RPLN) samples collected from 151 132 captive Iowa April 2020 through...