A5046257486- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Head and Neck Cancer Studies
- Urologic and reproductive health conditions
- Respiratory Support and Mechanisms
- Microbial Inactivation Methods
- Central Venous Catheters and Hemodialysis
- Brain Metastases and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Virus-based gene therapy research
- Congenital Diaphragmatic Hernia Studies
- Renal cell carcinoma treatment
- Cardiac Arrest and Resuscitation
- Ultrasound and Hyperthermia Applications
- Venous Thromboembolism Diagnosis and Management
- Animal Virus Infections Studies
- Wireless Body Area Networks
- Reconstructive Surgery and Microvascular Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mechanical Circulatory Support Devices
- Renal and related cancers
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer-related Molecular Pathways
Dana-Farber Brigham Cancer Center
2024
Brigham and Women's Hospital
2024
Dana-Farber Cancer Institute
2024
National Institutes of Health Clinical Center
2020-2023
Cleveland Clinic Lerner College of Medicine
2022
Case Western Reserve University
2014-2022
National Institutes of Health
2020-2021
National Cancer Institute
2020-2021
Cleveland Clinic
2017-2020
University of Pennsylvania
2015
Objective Organ preservation (OP) treatment for advanced laryngeal cancer has increased compared to primary total laryngectomy. Our study compares oncologic and functional outcomes between these approaches. Study Design Retrospective cohort study. Setting Single tertiary care institution. Methods review of patients receiving laryngectomy or OP 1/1/2000 12/31/2018. Results A 118 received 119 OP. Overall survival was similar When stratified by T stage, disease‐free worse among T3 versus In...
Abstract Background Mechanical ventilation worsens acute respiratory distress syndrome, but this secondary “ventilator-associated” injury is variable and difficult to predict. The authors aimed visualize the propagation of such ventilator-induced injury, in presence (and absence) a primary underlying lung determine predictors propagation. Methods Anesthetized rats (n = 20) received acid aspiration (hydrochloric acid) followed by with moderate tidal volume (VT). In animals surviving for at...
Inspiratory stretch by mechanical ventilation worsens lung injury. However, it is not clear whether and how the ventilator damages lungs in absence of preexisting We hypothesized that subtle loss aeration during general anesthesia regionally augments distension ventilated air spaces. In eight supine anesthetized intubated rats, hyperpolarized gas MRI was performed after a recruitment maneuver following 1 h volume-controlled with zero positive end-expiratory pressure (ZEEP), FiO2 0.5, tidal...
Background: Treatment for locally recurrent breast cancer poses a significant challenge because the benefits in local control must be weighed against increased risk of side effects treatment. Frequently, patients have been heavily pre-treated with radiation and several types chemotherapy. Moreover, they often present large volumes bulky disease, further complicating management. Hyperthermia can used to improve efficacy radiation, particularly setting disease.Methods: We reviewed our clinical...
No AccessJournal of UrologyAdult Urology1 Dec 2020PI-RADS® Category as a Predictor Progression to Unfavorable Risk Prostate Cancer in Men on Active SurveillanceThis article is commented by the following:Editorial Commentis corrected byErratum: PI-RADS® Surveillance Alex Z. Wang, Luke P. Oonnor, Nitin K. Yerram, Lori Long, Johnathan Zeng, Sherif Mehralivand, Stephanie A. Harmon, Amir H. Lebastchi, Michael Ahdoot, Patrick T. Gomella, Sandeep Gurram, Peter L. Choyke, Maria J. Merino, Joanna...
Active surveillance for patients with low and intermediate risk prostate cancers is becoming a more utilized option in recent years. However, the use of magnetic resonance imaging imaging-targeted biopsy monitoring grade progression has been poorly studied this population. We aim to define utility systematic an active population.Between July 2007 January 2020, diagnosed cancer who elected were monitored imaging, standard biopsy. Patients eligible if any volume Gleason 1 disease select 2...
About a third of all cancer patients develop brain metastases. Stereotactic radiosurgery (SRS) is common treatment for with metastases and offers excellent tumor control rates. However, the most significant clinical challenge after SRS reliably differentiating progression from radiation necrosis, side effect SRS, which occurs in about 20% metastatic patients. The current diagnostic accuracy distinguishing necrosis recurrence via visual inspection by expert radiologists on routine MRI scans...
We characterized cryoablation as a mode of clinical intervention in adult woodchucks with hepatocellular carcinoma (HCC). Woodchucks (
253 Background: Clinical study demonstrates that diabetic patients taking metformin while undergoing chemotherapy and/or radiation for localized pancreatic cancer have improved overall survival compared to diabetics not or non-diabetic (Sadeghi, Clin Cancer Res 2012). Metformin may act as a radiosensitizer through direct effects on cells indirect the host, such inhibition of hepatic gluconeogenesis inflammation (Pollak, In vitro include suppression mTOR, G2/M cell cycle arrest, and toxicity...
Objective: To determine the effects of different computed high b-value on diffusion weighted imaging (DWI) scores in Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) prostate cancer peripheral zone. Methods: A retrospective study 104 cases zone was conducted, all patients were histopathologically confirmed by transrectal ultrasound guided saturation biopsy or radical prostatectomy Tongji Hospital University from January 2012 to December 2015.All MRI examinations performed...
Abstract Background Teratomas are germ cell neoplasms composed of a wide variety tissues. In the woodchuck, only one testicular teratoma has been described in literature. The objective this report was to describe radiologic and pathologic findings female woodchuck ( Marmota monax ) with an ovarian consisting mature tissues originating from all three layers. Case presentation A 2-year-old that had infected at birth hepatitis virus subsequently developed hepatocellular carcinoma incidentally...
293 Background: Active surveillance (AS) is now considered a well-accepted alternative for low-favorable intermediate risk prostate cancer over definitive therapy. Few studies have incorporated the use of multi-parametric MRI (mpMRI) into treatment paradigm. In this study we investigate imaging findings that are predictive patient dropping off AS. Methods: Our institutional database was queried all patients who met criteria active from 11/2003 to 5/2017. Criteria inclusion included ≥ 2...
6533 Background: NCCN guidelines do not recommend routine surveillance imaging for distant failure (DF) after definitive treatment of head & neck squamous cell carcinoma (SCC). We hypothesized that there exists a subset patients with sufficiently high enough risk DF to benefit from imaging. This study attempts define cohorts oropharynx (OP) and oral cavity (OC) patients. Methods: A retrospective review was conducted SCC the OP or OC at single tertiary care institution 1994-2019. Patients...