A5050278592- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Glioma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Asian Studies and History
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Privacy-Preserving Technologies in Data
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Hemodynamic Monitoring and Therapy
- Acute Lymphoblastic Leukemia research
- Bone Tissue Engineering Materials
- MRI in cancer diagnosis
- Geology and Paleoclimatology Research
- Insurance, Mortality, Demography, Risk Management
- Southeast Asian Sociopolitical Studies
- Paleontology and Stratigraphy of Fossils
University of Chicago
2002-2025
Lankenau Medical Center
2023-2025
Main Line Health
2023-2025
NorthShore University HealthSystem
2025
National Heart Lung and Blood Institute
2021-2024
National Institutes of Health
2021-2024
The University of Texas at Austin
2012-2024
Nationwide Children's Hospital
2023
Case Western Reserve University
2020-2023
University of Maryland, Baltimore
2021-2023
Abstract Memory CD8 T cells acquire effector memory cell properties after reinfection and may reach terminally differentiated, senescent states (“Hayflick limit”) multiple infections. The signals controlling this process are not well understood, but we found that the degree of secondary differentiation was intimately linked to amount T-bet expressed upon reactivation preexisting number (i.e., primary precursor frequency) present during infection. Compared with naive cells, were predisposed...
To determine the role of CD49d for response to Bruton's tyrosine kinase inhibitors (BTKis) in patients with chronic lymphocytic leukemia (CLL).In treated acalabrutinib (n=48), expression, VLA-4 integrin activation, and tumor transcriptomes CLL cells were assessed. Clinical responses BTKis investigated (n=48; NCT02337829), ibrutinib (n=73; NCT01500733) patients.In acalabrutinib, treatment induced lymphocytosis was comparable both subgroups but resolved more rapidly CD49d+ cases. Acalabrutinib...
Recent epidemiological studies have suggested that sexual dimorphism influences treatment response and prognostic outcome in glioblastoma (GBM). To this end, we sought to (i) identify distinct sex-specific radiomic phenotypes-from tumor subcompartments (peritumoral edema, enhancing tumor, necrotic core) using pretreatment MRI scans-that are of overall survival (OS) GBMs, (ii) investigate radiogenomic associations the MRI-based phenotypes with corresponding transcriptomic data, signaling...
Introduction: Plasmacytoid dendritic cells (pDC) are unique antigen-presenting that may be implicated in allergic disease because they bind IgE on their surface and modulate important Th1/Th2 cytokine responses. The authors previously discovered is not readily removed from pDCs using omalizumab to the same extent observed for basophils, suggesting a portion of membrane bound. Methods: A cross-sectional study was performed recruited adult volunteers Johns Hopkins Asthma & Allergy Clinic,...
Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing traditional role chatbots. These can leverage planning and tool utilization capabilities address tasks specified at a high level. However, standardized dataset benchmark the agent of LLMs medical applications is currently lacking, making evaluation on complex interactive healthcare environments challenging. To this gap, we introduce...
BACKGROUND: Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing traditional role chatbots. These can leverage planning and tool utilization capabilities address tasks specified at a high level. This suggests new potential reduce the burden of administrative current healthcare staff shortages. However, standardized dataset benchmark agent LLMs medical applications is currently lacking, making...
University of Chicago (NorthShore) Family Medicine Program, Evanston, IL The corresponding author is Nathan Holt; [email protected] No funding was received for this study. authors declare no conflict interest.
Objective: To determine whether vasopressin could be effective in treating the hypotension associated with phosphodiesterase III inhibition. Phosphodiesterase inhibitors are cardiotonic agents that increase myocardial contractility and decrease vascular smooth muscle tone. The vasodilatory effect can profound, resulting frequently requires administration of catecholamine pressors. Design: Retrospective analysis existing data. Setting: medical or surgical intensive care unit...
Utilising Pitkin’s concept of representation, this article surveys the landscape Chinese Indonesian political representation since advent regional elections in 1999. Analyses dataset individual profiles executives, as they adopt inclusive-pairing tactics by taking on deputised roles or appeal using charisma, had demonstrated that there was a visible transition from “descriptive” towards more “substantive” forms various constituencies – seen most important dimension ideal despite presence...
B cells, but not T are considered to be important for the formation of follicular dendritic cell (FDC) clusters. Stimulation with agonist mAbs against CD137 (4-1BB), a TNFR family member primarily expressed on activated was effective in promoting responses, paradoxically suppressed T-dependent humoral immunity and autoantibody production autoimmune disease models. Our present study shows that agonistic anti-CD137 treatment activates resulting diminished FDC networks follicles, which...
AbstractB-cell targeted therapies, including anti-CD20 monoclonal antibodies (mAb) and Bruton's tyrosine kinase inhibitors (BTKi), further suppress antibody (Ab) response to vaccines in patients with chronic lymphocytic leukemia (CLL). We conducted a prospective cohort study of SARS-CoV-2 vaccination 81 CLL receiving BTKi (n = 54), venetoclax (VEN, n 9), or who were treatment naïve (TN, 18). Anti-spike Ab detected 53% on post-primary series 84% post-booster, 57% VEN 50% 67% TN 87%...
Soft implant surfaces should be designed with an eye toward natural, healthy biointerfaces, which use high water content aqueous gel gradients to reduce contact pressures and frictional shear stresses thus inflammation discomfort.
Medulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four subgroups of MB (WNT, SHH, Group 3, 4), each with distinct clinical behaviors. We hypothesize that (1) aggressive tumors, growing heterogeneously, induce pronounced local structural deformations the surrounding parenchyma, and (b) these as captured on Gadolinium (Gd)-enhanced-T1w MRI are independently associated subgroups, well overall survival patients.In this work,...
Transcranial electrical motor evoked potential (TcMEP) is a modality utilized in intraoperative neurophysiological monitoring to assess the integrity of corticospinal tract. Traditionally, TcMEPs are obtained by anodal stimulation scalp over cortex selected hemisphere and referenced contralateral hemisphere. Subsequent compound action responses (CMAPs) recorded at various muscles. The muscle interest usually those limb stimulation. However, may elicit simultaneous limbs ipsilateral...
Through nonwoven hydroentanglement of greige cotton blends with polyester and nylon, varying degrees fiber surface polarity, swelling, absorbance can be achieved. Electrokinetic properties made Ultra Clean™ (100% or virgin cotton) nylon in 40:60 60:40 ratios demonstrated distinct differences charge, swell, per-cent moisture uptake capability. An electrochemical double layer analysis charge based on a pH titration (pH 1.5–11 1 mM KCl) was employed to measure the relative fabric polarity (ζ...
Abstract Hematopoietic stem cell (HSC) transplantation (HST) is a curative treatment for many hematopoietic cancers and bone marrow (BM) disorders but currently limited by numerous complications including lengthy recovery period, prolonged neutropenia resulting in severe infections bleeding, high incidence of graft vs. host disease (GVHD). While clinical studies have demonstrated that sex mismatch, notably male recipients with female donor cells, results increased risk GVHD (likely due to...