A5055373979- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Explainable Artificial Intelligence (XAI)
- Stroke Rehabilitation and Recovery
- Advanced Image Processing Techniques
- Generative Adversarial Networks and Image Synthesis
- Peripheral Neuropathies and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Autoimmune Neurological Disorders and Treatments
- Brain Tumor Detection and Classification
- Machine Learning in Healthcare
University of Basel
2023-2025
University Hospital of Basel
2023-2025
University Hospital Heidelberg
2019-2024
Heidelberg University
2019-2024
University Hospital of Bern
2024
Universitätsklinikum Würzburg
2024
Charité - Universitätsmedizin Berlin
2012-2019
Freie Universität Berlin
2019
Humboldt-Universität zu Berlin
2019
The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven centres Europe. MAGIC consolidates clinical radiological from acute (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, combination of both, or conservative management. All ensure accuracy completeness the data. Only did not refuse use their routine collected during after hospital stay are included repository. Approvals waivers obtained...
Introduction Magnetic resonance imaging (MRI) using field strengths up to 3 Tesla (T) has proven be a powerful tool for stroke diagnosis. Recently, ultrahigh-field (UHF) MRI at 7 T shown relevant diagnostic benefits in of neurological diseases, but its value not been investigated yet. We present the first evaluation clinically feasible protocol T. For comparison an established was applied Methods In prospective study seven patients with subacute and chronic were included. Imaging immediately...
Pulsed arterial spin labeling (PASL) at multiple inflow times (multi-TIs) is advantageous for the measurement of brain perfusion in patients with long transit (ATTs) as steno-occlusive disease, because bolus-arrival-time can be measured and blood flow measurements corrected accordingly. Owing to its increased signal-to-noise ratio, a combination three-dimensional gradient echo (GRASE) readout allows acquiring sufficient number multi-TIs within clinically feasible acquisition time 5 minutes....
In brain perfusion imaging, arterial spin labeling (ASL) is a noninvasive alternative to dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI). For clinical only product sequences can be used. We therefore analyzed the performance of sequence (PICORE-PASL) included in an MRI software-package compared with DSC-MRI patients steno-occlusion MCA or ICA >70%.Images were acquired on 3T system and qualitatively by 3 raters. quantitative analysis, cortical ROIs placed co-registered...
Outcome prediction after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large vessel occlusion (LVO) is commonly performed by focusing on favorable outcome (modified Rankin Scale, mRS 0-2) 3 months but poor representing severe disability mortality (mRS 5 6) might be of equal importance for clinical decision-making.We retrospectively analyzed AIS LVO undergoing MT from 2009 to 2018. Prognostic variables were grouped baseline (A), MRI-derived including mismatch...
This cross-sectional study examines whether proposed myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) diagnostic criteria can exclude other diseases, such as multiple sclerosis, and rely on results of cell-based assays.
In acute stroke, the DWI-FLAIR mismatch allows for allocation of patients to thrombolysis window (<4.5 hours). FLAIR-lesions, however, may be challenging assess. comparison, DWI a useful bio-marker owing high lesion contrast. We investigated performance relative signal intensity (rSI) threshold predict presence FLAIR-lesions in stroke and analyzed its association with time-from-stroke-onset.In retrospective, dual-center MR-imaging study we included time-from-stroke-onset ≤12 hours (group A:...
Abstract Despite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast-enhanced blood-brain barrier permeability imaging may help determine secondary stroke injury predict clinical outcome. We prospectively performed 38 within 24 h after mechanical thrombectomy an occlusion the middle cerebral artery M1 segment. Perfusion alterations were...
Endovascular stroke treatment (EST) is commonly performed for acute basilar artery occlusion (BAO). We aimed to identify the role of exact location BAO in patients receiving EST regarding etiology, recanalization success and prediction favorable clinical outcome.Retrospective analysis 191 consecutive treated with from 01/2013 until 06/2021 a tertiary center. Groups were defined according I: proximal third, II: middle III: distal third IV: tip artery. Univariate multivariate analyses...
Arterial spin labeling (ASL) is an MRI technique to measure cerebral blood flow (CBF) without the need of exogenous contrast agents and thus a promising alternative clinical standard dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion imaging. Latest international guidelines encourage its application in setting. However, susceptibility-induced image distortions impair ASL with fast readout modules (eg Echo Planar Imaging, EPI; gradient echo, GRASE). In present study, we...
Stroke is a major cause of death or disability. As imaging-based patient stratification improves acute stroke therapy, dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) interest in image brain perfusion. However, expert-level perfusion maps require manual semi-manual post-processing by medical expert making the procedure time-consuming and less-standardized. Modern machine learning methods such as generative adversarial networks (GANs) have potential to automate map...
Abstract Background and Purpose Brain perfusion measurement in the subacute phase of stroke may support therapeutic decisions. We evaluated whether arterial spin labeling (ASL), a noninvasive imaging technique based on magnetic resonance (MRI), adds diagnostic prognostic benefit to diffusion‐weighted (DWI) stroke. Methods In single‐center study, patients with DWI lesion(s) middle cerebral artery (MCA) territory were included. Onset time was ≤7 days included ASL sequences. Qualitative...
We hypothesize that the detectability of early ischemic changes on non-contrast computed tomography (NCCT) is limited in hyperacute stroke for both human and machine-learning based evaluation. In short onset-time-to-imaging (OTI), CT angiography collateral status may identify fast progressors better than quantified by ASPECTS. this retrospective, monocenter study, collaterals (Tan score) ASPECTS acute follow-up NCCT were evaluated two raters. Additionally, a algorithm scale (e-ASPECTS)....
Automated CT perfusion mismatch assessment is an established treatment decision tool in acute ischemic stroke. However, the reliability of this method patients with head motion unclear. We therefore sought to evaluate influence movement on automated evaluation.Using a realistic brain-perfusion-phantom, 7 scenarios were simulated within left middle cerebral artery territory. Real noise and artificial added. Thereafter, core, penumbra volumes ratios evaluated using analysis software (RAPID,...
To generate perfusion parameter maps from Time-of-flight magnetic resonance angiography (TOF-MRA) images using artificial intelligence to provide an alternative traditional imaging techniques.
Introduction: Thrombectomy complications remain poorly explored. This study aims to characterize periprocedural intracranial vessel perforation including the effect of thrombolysis on patient outcomes. Patients and methods: In this multicenter retrospective cohort study, consecutive patients with during thrombectomy between January 2015 April 2023 were included. Vessel was defined as active extravasation digital subtraction angiography. The primary outcome modified Rankin Scale (mRS) at 90...
Purpose: To develop an open-source nnU-Net-based AI model for combined detection and segmentation of unruptured intracranial aneurysms (UICA) in 3D TOF-MRI, compare models trained on datasets with aneurysm-like differential diagnoses. Methods: This retrospective study (2020-2023) included 385 anonymized TOF-MRI images from 364 patients (mean age 59 years, 60% female) at multiple centers plus 113 subjects the ADAM challenge. Images featured untreated or possible UICAs Four distinct training...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Patterns of the cerebral microcirculatory response with changes in blood brain barrier and perfusion patients stroke a large vessel occlusion are still unclear. We combined dynamic contrast enhancement (DCE) permeability DSC MRI to detect such patterns beyond borders diffusion-restricted infarct core after successful recanalization. <h3>MATERIALS METHODS:</h3> Combined DCE were performed prospectively within 24h mechanical recanalization...
Octogenarians are underrepresented in recently published studies that showed the benefit of endovascular stroke treatment (EST) for patients with acute basilar artery occlusion (BAO). We aimed to compare clinical outcome octogenarians BAO and EST compared younger (YPs) identify independent predictors.This is a retrospective, single-center analysis treated from January 2013 until June 2021 tertiary center. (80-89 years) were YPs. A study endpoint was favorable as per modified Rankin Scale...
Introduction and hypothesis: MR-TOF angiography (magnetic resonance time of flight) offers a rapid, non-invasive assessment the intracranial vessel status in patients with cerebrovascular diseases. As signal is flow-dependent, we hypothesized that quantification can predict perfusion respective flow territory as well degree proximal stenosis. Methods: Within PEGASUS study (WHO REG-NR DRKS00003198) performed TOF imaging contrast agent (DSC, dynamic susceptibility-weighted contrast-enhanced)...
Abstract Background and Aims Elderly patients, especially octogenarians, are underrepresented in recently published studies, that showed a benefit of endovascular stroke treatment (EST) for patients with acute basilar artery occlusion (BAO). We aimed to compare the clinical outcome octogenarians BAO EST compared younger identify independent predictors. Methods This is retrospective, single-center analysis treated from 01/2013 until 06/2021 tertiary center. Octogenarians (≥ 80 years) were...