A5049505360- Urinary Bladder and Prostate Research
- Parkinson's Disease Mechanisms and Treatments
- Pelvic floor disorders treatments
- Restless Legs Syndrome Research
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Urinary Tract Infections Management
- Botulinum Toxin and Related Neurological Disorders
- Gastrointestinal motility and disorders
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Migraine and Headache Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Metabolism and Genetic Disorders
- Neurosurgical Procedures and Complications
- Neuroscience of respiration and sleep
- Neurological diseases and metabolism
- Spinal Dysraphism and Malformations
- Hormonal and reproductive studies
- Dysphagia Assessment and Management
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
Chiba University
2011-2024
International University of Health and Welfare
2018-2024
Toho University Medical Center Sakura Hospital
2012-2023
Toho University
1978-2023
National Hospital for Neurology and Neurosurgery
2019-2021
University College London
2019-2021
Dokkyo Medical University
2012-2020
Foundation for Human Potential
2010
Seirei Hamamatsu General Hospital
2009
Hamamatsu University School of Medicine
2009
Abstract Mosapride citrate is a novel selective 5‐HT4 receptor agonist. It facilitates acetylcholine release from the enteric cholinergic neurons. In contrast to cisapride, mosapride does not block K + channels or D2 dopaminergic receptors. The objective of this study perform an open citrate's effects on constipation, prominent lower gastrointestinal tract disorder in parkinsonian patients. A total 14 patients (7 with Parkinson's disease, 7 multiple system atrophy; 10 men, 4 women; mean age,...
Constipation is a prominent lower gastrointestinal tract dysfunction that occurs frequently in Parkinson's disease (PD).To investigate colonic transport and dynamic rectoanal behaviour during filling defecation patients with PD.Colonic transit time (CTT) videomanometry analyses were performed 12 PD (10 men 2 women; mean age, 68 years, duration of disease, five years; Hoehn Yahr grade, 3; decreased stool frequency (<3 times week) six, difficulty expulsion eight) 10 age matched normal control...
<h3>OBJECTIVES</h3> To investigate urinary function in the elderly with and without white matter lesion (leukoaraiosis) relation to cognitive gait function. <h3>METHODS</h3> Sixty three subjects were examined, mean age 73 (range 62 86 years). Subjects brainstem stroke or large hemispheric lesions excluded. Spin echo 1.5 T MRI images graded from 0 4 for severity of lesions. Urinary was assessed by detailed questionnaire urodynamic studies performed 33 subjects, including measurement...
To elucidate the mechanism of bladder dysfunction in idiopathic normal pressure hydrocephalus (iNPH) by a urodynamic study.Forty-two patients with possible iNPH, who were diagnosed clinical symptoms/signs (gait, cognitive, and urinary disorders) typical imaging features (ventricular enlargement) cerebrospinal fluid pressure, enrolled. The subjects included 36 men 6 women; mean age, 72 years (62-83 years). All underwent test according to definitions methods proposed International Continence...
Bladder dysfunction (urinary urgency/frequency), bowel (constipation), and sexual (erectile dysfunction) (also called “pelvic organ” dysfunctions) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, pelvic organ autonomic dysfunctions often nonresponsive levodopa treatment. The brain pathology causing the bladder (appearance of overactivity) involves an altered dopamine-basal ganglia circuit, which normally suppresses micturition reflex. By contrast,...
TAR DNA binding protein of 43 kDa (TDP-43) is likely to be the major pathogenetic in amyotrophic lateral sclerosis (ALS). A previous study has shown that levels TDP-43 CSF measured by an ELISA are significantly higher for ALS patients than controls. The aim this was investigate whether elevated specific ALS, and associated with clinical profiles patients. We same 27 50 neurodegenerative or inflammatory disease controls such as Parkinson's disease, multiple sclerosis, Guillain-Barré syndrome.
Abstract Aim: The aim of the present study was to compare effectiveness a cholinergic drug, an α‐blocker and combinations two for treatment underactive detrusor. Methods: One hundred nineteen patients with bladder were assigned three groups: group, consisting 40 taking bethanechol chloride (60 mg/day) or distigmine bromide (15 mg/day); 38 urapidil combination 41 both drug α‐blocker. each therapy assessed 4 weeks after initialization therapy. Results: Total urinary symptom scores...
Abstract We investigated the short‐term effects of a single dose levodopa ( L ‐dopa) on micturition function in PD patients with wearing‐off phenomenon. Eighteen who had median Hoehn and Yahr scores 5 during off phase 3 were recruited. carried out urodynamic studies before about 1 hour after taken 100 mg ‐dopa dopa‐decarboxylase inhibitor (DCI). After taking ‐dopa/DCI, urinary urgency urge incontinence aggravated, whereas voiding difficulty was alleviated all 12 patients. When compared to...
Neurogenic urinary retention can be a major cause of morbidity in multiple-system atrophy (MSA). However, the timing its appearance has not been entirely clear, and neither have medical surgical modalities for managing patients. We present data obtained from our uroneurological assessment therapeutic interventions at various stages MSA. recruited 245 patients with probable measured postvoid residuals (PVR) performed EMG cystometry all The grand average volume PVR was 140 mL (range, 0-760) 71...
To study diabetic cystopathy with reference to overactive bladder (OAB).We retrospectively analyzed in our digitized database that comprised 2300 case records, including data from a lower urinary tract symptoms questionnaire, urodynamic study, and neurological examinations.Diabetic was seen 4% of cases (84 cases): 58 males, 26 females; mean age, 60.8 years; duration diabetes, 143.5 months; HbA1C, 7.7 %. In addition large post-void residual decreased sensation, OAB, detrusor overactivity...
<h3>Objectives</h3> To investigate the impact of sleep disturbances on Parkinson’s disease (PD) clinical motor subtypes and disease-related disability in a multicentre setting. <h3>Methods</h3> We report cross-sectional relationship between sleep-related symptoms (tremor dominant (TD); intermediate; postural instability gait (PIGDs)) identified study, including 436 patients with PD 401 age-matched controls. PD-related problems (PD-SP), excessive daytime sleepiness (EDS) probable REM...
Detrusor hyperactivity with impaired contractile function (DHIC) was originally described in elderly women. It has not previously been well known whether neurological diseases cause DHIC. We investigated which commonly DHIC our laboratory.We searched for laboratory's computerized database of 1,514 case records, included a lower urinary tract (LUT) symptom questionnaire and urodynamic study results. defined as the presence both (1) detrusor overactivity during storage phase, (2) underactive...
To compare three positions for defecation by measuring abdominal pressure and the anorectal angle simultaneously.We recruited six healthy volunteers. The videomanometric measures included simultaneous fluoroscopic images, pressures, subtracted rectal pressures anal sphincter pressures. Three were used: sitting, sitting with hip flexing at 60 ° respect to rest of body, squatting 22.5 body.Basal before on hip-flex was lower than that normal although difference did not reach statistical...