A5041650344- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Migraine and Headache Studies
- Sleep and Wakefulness Research
- Neurological disorders and treatments
- Ubiquitin and proteasome pathways
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Multiple and Secondary Primary Cancers
- Central Venous Catheters and Hemodialysis
- Dysphagia Assessment and Management
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Peripheral Neuropathies and Disorders
- Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Eosinophilic Disorders and Syndromes
- Glycogen Storage Diseases and Myoclonus
- NF-κB Signaling Pathways
- Streptococcal Infections and Treatments
- Actinomycetales infections and treatment
- Long-Term Effects of COVID-19
- Infection Control in Healthcare
- Ophthalmology and Eye Disorders
Tokyo Medical University Hospital
2015-2025
Dokkyo Medical University
2016-2025
Kyoto University
2024
Tokyo Medical University
2015-2021
Suzuki (Japan)
2020
National Patient Safety Foundation
2020
Weatherford College
2020
Committee on Publication Ethics
2020
Osaka University
1992-2017
Mie Chuo Medical Center
2017
The purpose of this study was to identify the clinical characteristics and outcomes peripheral vascular catheter-related bloodstream infections (PVC-BSIs) determine risk severe complications or death. We performed a retrospective observational from June 2010 April 2015 at two regional university-affiliated hospitals in Tokyo. studied manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, 62 hospitalized patients diagnosed with PVC-BSIs by positive blood...
The linear ubiquitin chain assembly complex (LUBAC) is a key nuclear factor-κB (NF-κB) pathway component that produces polyubiquitin chains. HOIL-1L subunit of LUBAC has been shown to bind chains; however, detailed structural and functional analyses on the binding between chains have not performed. In this study, we found Npl4 zinc finger (NZF) domain specifically binds determined crystal structure NZF in with diubiquitin at 1.7-Å resolution. consists zinc-coordinating “NZF core” region an...
Background: The coronavirus disease 2019 (COVID-19) pandemic has negatively affected the mental health of general population. Objective: We investigated determinants quality life (QOL) in Parkinson’s (PD) patients during COVID-19 pandemic. Methods: Impacts lifestyle changes due to on 100 with PD and their caregivers/spouses were assessed. Hospital Anxiety Depression Scale was used assess anxiety depression. physical component summary (PCS) (MCS) scores short form (SF)-8 evaluate...
Real-world data on the effectiveness of calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) in migraine patients are needed.We performed a single-center, real-world study with an observation period up to 12 months (mean 7.5 ± 3.4 months) after CGRP mAb administration. A total 228 Japanese episodic or chronic (age, 45.9 13.2 years; 184F; 45 erenumab; 60 galcanezumab; 123 fremanezumab) who were treated mAbs for at least three ultimately included this study.In cohort, treatment,...
The Parkinson's Disease Sleep Scale (PDSS)-2 is a recently developed tool for evaluating disease-related nocturnal disturbances in patients with disease (PD). However, its cutoff score has not been clinically assessed. We determined the optimal of Japanese version PDSS-2.Patients PD (n = 146) and controls 100) completed PDSS-2 Pittsburgh Quality Index (PSQI). Poor sleepers were defined as having global PSQI scores >5. Optimal determining poor assessed using receiver operating characteristic...
Objective Sleep disturbances are common in migraine patients and affect quality of life. Central sensitization (CS) is likely to play a role the increased severity chronicity migraine. We hypothesized that number comorbid sleep problems would headache-related disability through effects central (CS). Methods performed cross-sectional study including 215 consecutive with Insomnia was defined as Pittsburgh Quality Index (PSQI) global score greater than 5. Probable REM behavior disorder (pRBD)...
Calcitonin gene-related peptide monoclonal antibody (CGRP mAb) effects on restless legs syndrome (RLS) are unclear. Fifteen migraine patients (aged 49.1 ± 5.8 years; 14 women) with concomitant RLS who received CGRP mAbs (2 erenumab, 3 galcanezumab, and 10 fremanezumab) were retrospectively studied. Number of monthly days (MMDs) was obtained from headache diaries. The primary outcome is changes in severity as assessed by the International Group Rating Scale (IRLS). Headache-related disability...
The effectiveness of patient participation in hand hygiene (HH) programmes Japan is unclear. This study examines the effect a empowerment HH programme at Japanese hospital. Two periods were analysed: January 2020 to November as baseline, and December April 2021 intervention period. involved inpatients observing practices healthcare workers. average number events per patient-day increased from 23.4 baseline 37.3 during intervention. positively correlated with observations. Patient may...
Background We aimed to evaluate the utility of combined use cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, olfactory testing, and substantia nigra (SN) hyperechogenicity on transcranial sonography (TCS) in differentiating Parkinson's disease (PD) from atypical parkinsonian syndromes (APSs), such as multiple system atrophy (MSA) progressive supranuclear palsy (PSP). Methods Cardiac MIBG card-type odor identification testing (Open Essence (OE), Wako, Japan), TCS were performed with...
<b><i>Objective:</i></b> The objective of this study was to clarify the relationship between autonomic and non-autonomic non-motor symptoms in patients with Parkinson’s disease (PD). <b><i>Methods:</i></b> Sixty-five PD were included (27 men 38 women; aged 68.5 ± 10.0; Hoehn Yahr (HY) stage 2.6 1.1). evaluated by Japanese version Scales for outcomes (SCOPA-AUT) questionnaire. assessed mini-mental state examination (MMSE), sleep evaluation...
Background Sleep disturbances and excessive daytime sleepiness (EDS) are common non-motor symptoms in patients with Parkinson's disease (PD). The purpose of this study was to identify the contributors sleep disturbances, including insomnia, restless legs syndrome, rapid eye movement behavior disorder (RBD), sleep-disordered breathing, nocturnal akinesia EDS, PD. Methods We conducted a cross-sectional 128 consecutive Japanese EDS were defined as PD Scale-2 (PDSS-2) total score ≥15 an Epworth...
Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty accurate species identification C. gilardii, there are few case reports infection caused by this organism. In previous reports, has been characterized as organism with low pathogenicity causes opportunistic infections. We encountered a pacemaker-associated bloodstream 90-year old woman without obvious immunodeficiency. isolates sequencing 16S rRNA gene....
Continuous subcutaneous infusion of foslevodopa/foscarbidopa (LDP/CDP) may be effective in improving daytime symptoms patients with Parkinson's disease (PD). We report on a PD patient for whom LDP/CDP treatment improved motor symptoms, sleep disturbances and architecture as measured by the mobile two-channel electroencephalography/electrooculography recording system.
In our previous paper, we have reported that niacin-related compounds, particularly picolinic acid, dipicolinic and isonicotinamide, induced apoptosis in HL-60 cells but niacin did not. Moreover, picolinamide, N1-methylnicotinamide, 6-aminonicotinamide, quinolinic cinchomeronic acid also had the function of DNA fragmentation analyzed by flow cytometry, ratio finally being about 40% after treatment with these compounds at 10 mM for 24 h. this study, found cells. The wide-spectrum caspase...
A case of severe endocarditis, with complications multiple infarction, meningitis, and ruptured mitral chordae tendineae, caused by Streptococcus agalactiae in a healthy man, is reported. Emergency cardiovascular surgery was performed on the day admission. Infective endocarditis S. very rare, particularly adult. In addition, microbiological analysis revealed that sequence type (ST) 19, which belongs to serotype III, present patient's vegetation, valve, blood culture. It therefore concluded...