A5061041464- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Hormonal and reproductive studies
- Restless Legs Syndrome Research
- Prostate Cancer Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Sexual function and dysfunction studies
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Botulinum Toxin and Related Neurological Disorders
- Bladder and Urothelial Cancer Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Renal cell carcinoma treatment
- Spinal Dysraphism and Malformations
- Migraine and Headache Studies
- Hernia repair and management
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Pain Management
- Receptor Mechanisms and Signaling
- Thermoregulation and physiological responses
Dokkyo Medical University
2015-2024
Yokohama Rosai Hospital
2022-2023
Saiseikai Utsunomiya hospital
2022-2023
Chiba Prefectural Sawara High School
2022-2023
Chiba University
1998-2022
Dokkyo University
2002-2014
Toho University Medical Center Sakura Hospital
2012
Toho University
2012
Tochigi Medical Center
2012
Robotics Research (United States)
2011
Abstract The Rho family of GTPases are involved in actin cytoskeleton organization and associated with carcinogenesis progression human cancers. We investigated the roles GTPases, prototypes RhoA, Rac1, Cdc42, major downstream targets ROCK-I, ROCK-II testicular cancer. quantified protein expression paired tumor nontumor samples from surgical specimens 57 consecutive patients germ cell tumors using Western blotting. Protein ROCK-II, Cdc42 was significantly higher tissue than (P <...
Abstract The present article is the abbreviated English translation of Japanese guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia updated as end 2016. target patients are men aged >50 years complaining symptoms, with or without hyperplasia, readers non‐urological general physicians urologists. Mandatory assessment medical history, physical examination, urinalysis measurement serum prostate‐specific antigen. Additional mandatory urologists quality life by...
1 The objective was to determine the role of muscarinic receptor subtypes in mediating contraction human detrusor smooth muscle vitro. 2 Contractile responses strips carbachol were obtained absence and presence a range antagonists (pirenzepine, methoctramine, 4-diphenylacetoxy-N-methyl piperidine methiodide (4-DAMP), tropicamide, oxybutynin tolterodine). Affinity estimates (pKB values) calculated for correlated with values at cloned quoted literature. 3 Pirenzepine, methoctramine tropicamide...
Constipation is a prominent lower gastrointestinal tract dysfunction that occurs frequently in Parkinson's disease (PD).To investigate colonic transport and dynamic rectoanal behaviour during filling defecation patients with PD.Colonic transit time (CTT) videomanometry analyses were performed 12 PD (10 men 2 women; mean age, 68 years, duration of disease, five years; Hoehn Yahr grade, 3; decreased stool frequency (<3 times week) six, difficulty expulsion eight) 10 age matched normal control...
To elucidate the mechanism of bladder dysfunction in idiopathic normal pressure hydrocephalus (iNPH) by a urodynamic study.Forty-two patients with possible iNPH, who were diagnosed clinical symptoms/signs (gait, cognitive, and urinary disorders) typical imaging features (ventricular enlargement) cerebrospinal fluid pressure, enrolled. The subjects included 36 men 6 women; mean age, 72 years (62-83 years). All underwent test according to definitions methods proposed International Continence...
Bladder dysfunction (urinary urgency/frequency), bowel (constipation), and sexual (erectile dysfunction) (also called “pelvic organ” dysfunctions) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, pelvic organ autonomic dysfunctions often nonresponsive levodopa treatment. The brain pathology causing the bladder (appearance of overactivity) involves an altered dopamine-basal ganglia circuit, which normally suppresses micturition reflex. By contrast,...
To identify the symptoms of higher relevance in patients complaining lower urinary tract (LUTS).A questionnaire covering 25 LUTS as defined by International Continence Society (ICS) terminology committee was administered to 1000 adults and 360 not (controls). Symptoms were 'highly relevant (core LUTS)' when indicated at least 25% symptomatic with nine common diseases/conditions one three that had a significant impact on their daily life.Ten (daytime frequency, nocturia, urgency, urgency...
Abstract The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) men with suspected BPH, which have been abridged and translated into English. This article is a shortened version of the English translation. were formulated on basis evidence retrieved from PubMed database between 1995 2009, as well other relevant sources. target patients these are users urologists. A mandatory assessment should include medical history, physical examination,...
Abstract The present article is an abridged English translation of the Japanese clinical guidelines for diagnosis and treatment lower urinary tract dysfunction in patients with spinal cord injury updated as July 2019. are adult injured dysfunction; special consideration pediatric elderly populations presented separately. target audience healthcare providers who engaged medical care injury. mandatory assessment includes history, physical examination, frequency‐volume chart, urinalysis, blood...
We designed an investigational study and a placebo controlled, double-blind to evaluate the usefulness of electrical pelvic stimulation in stress incontinence.We studied 44 patients with incontinence (six men 38 women, age 63 +/- 13), including 9 35 study. used 50 Hz. square waves 1 ms. pulse duration for stimulation. A vaginal electrode was women anal men. Urethral pressure profile before, during after 15-minute measured In trial active device dummy were used, efficacy judged from patient...
Abstract Aim: The aim of the present study was to compare effectiveness a cholinergic drug, an α‐blocker and combinations two for treatment underactive detrusor. Methods: One hundred nineteen patients with bladder were assigned three groups: group, consisting 40 taking bethanechol chloride (60 mg/day) or distigmine bromide (15 mg/day); 38 urapidil combination 41 both drug α‐blocker. each therapy assessed 4 weeks after initialization therapy. Results: Total urinary symptom scores...
Abstract We investigated the short‐term effects of a single dose levodopa ( L ‐dopa) on micturition function in PD patients with wearing‐off phenomenon. Eighteen who had median Hoehn and Yahr scores 5 during off phase 3 were recruited. carried out urodynamic studies before about 1 hour after taken 100 mg ‐dopa dopa‐decarboxylase inhibitor (DCI). After taking ‐dopa/DCI, urinary urgency urge incontinence aggravated, whereas voiding difficulty was alleviated all 12 patients. When compared to...
Neurogenic urinary retention can be a major cause of morbidity in multiple-system atrophy (MSA). However, the timing its appearance has not been entirely clear, and neither have medical surgical modalities for managing patients. We present data obtained from our uroneurological assessment therapeutic interventions at various stages MSA. recruited 245 patients with probable measured postvoid residuals (PVR) performed EMG cystometry all The grand average volume PVR was 140 mL (range, 0-760) 71...
To study diabetic cystopathy with reference to overactive bladder (OAB).We retrospectively analyzed in our digitized database that comprised 2300 case records, including data from a lower urinary tract symptoms questionnaire, urodynamic study, and neurological examinations.Diabetic was seen 4% of cases (84 cases): 58 males, 26 females; mean age, 60.8 years; duration diabetes, 143.5 months; HbA1C, 7.7 %. In addition large post-void residual decreased sensation, OAB, detrusor overactivity...