A5034123005- Plant and animal studies
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Insect-Plant Interactions and Control
- Cardiac Imaging and Diagnostics
- Asthma and respiratory diseases
- Insect symbiosis and bacterial influences
- Acute Myocardial Infarction Research
- Lepidoptera: Biology and Taxonomy
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Practices and Patient Outcomes
- Study of Mite Species
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neuropharmacology Research
- Pediatric health and respiratory diseases
- Diabetes Management and Research
- Medication Adherence and Compliance
- Allergic Rhinitis and Sensitization
- Anesthesia and Neurotoxicity Research
- Advanced Glycation End Products research
- Bone Metabolism and Diseases
- Teleoperation and Haptic Systems
Saga University
2011-2025
National Institute for Environmental Studies
2015-2024
National Institute of Environmental Research
2023
Osaka Metropolitan University
2022
National Institute for Japanese Language and Linguistics
2021
Kyushu University
2016-2018
Osaka Prefecture University
2001-2017
Fukushima Medical University
2017
Kitakyushu City Hospital Organization
2015
Tokyo University of Science
2006-2008
Integration of hepatitis B virus (HBV) DNA into host is detected in about 90% HBV-related hepatocellular carcinoma (HCC), but the preferential sites viral integration etiologically relevant to oncogenesis have been controversial. By using an adaptor-ligation/suppression-PCR, we identified four integrations myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) gene from 10 HCC patients with positive HBV surface antigen (HBsAg). Determination cellular-virus junction demonstrated that various...
Pesticides may have serious negative impacts on bee populations. The pesticide exposure of bees could depend the surrounding landscapes in which they forage. In this study, we assess across various land-use categories, while targeting Japanese honey bee, Apis cerana japonica, a native subspecies eastern bee. project involving public participation, measured concentrations major pesticides and beeswax collected from 175 colonies Japan quantitatively analyzed relationships between...
Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant fosmidomycin, a specific inhibitor the non-mevalonate pathway, just like fosfomycin. glpT fosfomycin and also fosmidomycin. This fact shows that fosmidomycin was transported inside via glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed transcription other genes concerning glycerol utilization highly dependent on presence cAMP.
Ossification of the posterior longitudinal ligament spine (OPLL) is leading cause myelopathy in Japan and diagnosed by ectopic bone formation paravertebral ligament. OPLL a systemic high mass disease with strong genetic background. To detect genes relevant to pathogenesis OPLL, we performed cDNA microarray analysis systematic gene expression profiles during osteoblastic differentiation cells from patients (OPLL cells), disorder called ossification yellow (OYL), non-OPLL controls together...
The purpose of this study was to elucidate the effects glimepiride on levels biomarkers related cardiovascular regulation in patients with type 2 diabetes mellitus. Thirty-four received for 24 weeks. Significant decreases glyceraldehyde-derived advanced glycation end products, (glycer-AGE: toxic AGE), eotaxin and fibroblast growth factor (FGF)-2 were recognized after administration glimepiride. Moreover, there trends be increases granulocyte-colony stimulating (G-CSF) granulocyte...
Background: Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed Japan to determine factors related medication non-adherence. Objective: The aim of this study was identify prescription non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs). Methods: A retrospective cross-sectional survey data about implementation dosing regimen at...
The rupture of an intracranial aneurysm (IA) results in subarachnoid hemorrhage, a catastrophic neurological condition with high morbidity and mortality. Following-up on our previous genome-wide linkage study Japanese population, we extensively analyzed 4.6 Mb region around D7S2472 7q11 by genotyping 168 single nucleotide polymorphisms (SNPs). SNP association window scan haplotype-based studies revealed susceptibility locus for IA LD block covering the 3′-untranslated (3′-UTR) ELN entire...
Abstract Background Recently, incretin hormones, including glucagon-like peptide-1 (GLP-1) analogue and dipeptidyl peptidase-4 (DPP-4) inhibitor, have been found to regulate glucose metabolism. The aim of this study was elucidate the efficacy safety clinical usage DPP-4 inhibitors in Japan. Methods This designed as a prospective, open-label, multi-center trial. Patients with diabetes mellitus type 2 (T2DM) poor glycemic profiles (HbA1c ≥ 6.2%) spite receiving medical diet, therapeutic...
The high performance liquid chromatographic procedure was established for the determination of ergothioneine in biological materials. is also applicable to purification 3H-ergothioneine. metabolism given rats very slow ; not disappear even after 1 week fasting. administrated mostly concentrated liver and level 10 times as that blood. All blood found corpuscles 24 hr administration.
To better understand the molecular pathogenesis of OPLL (ossification posterior longitudinal ligament) spine, an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from patients. We found that TSG-6 (tumour necrosis factor α-stimulated gene-6) is down-regulated during osteoblastic differentiation. Adenovirus vector-mediated overexpression inhibited differentiation human mesenchymal stem induced by BMP (bone morphogenetic protein)-2 or OS...
To conserve local biodiversity and ensure the provision of pollination services, it is essential to understand impact pesticides on wild honey bees. Most studies that have investigated effects bees focused European bee (Apis mellifera (Hymenoptera: Apidae)), which commonly domesticated worldwide. However, Asian cerana) widely distributed throughout Asia, toxicity data are lacking for this species. This study aimed fill important knowledge gap. In study, we determined acute contact in A....
We investigated the effects of morphological characteristics cucumber, Cucumis sativus L., seedlings grown at different vapor pressure deficits (VPDs) on initial colonization whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) biotype B. The were a VPD 3.8 or 0.4 kPa for 9 d 30 degrees C under photoperiod 12:12 (L:D) h. Pairs seedlings, one high and other low VPD, then installed in cages with 1.3 kPa, adults between 150 200 released. Leaves high-VPD had fewer than those low-VPD 24 h...
Determining the success of eradication an invasive species requires a way to decide when its risk reoccurrence has become acceptably low. In Japan, area populated by Argentine ant, Linepithema humile (Mayr), is expanding, and via chemical treatment ongoing at various locations. One such program in Tokyo was apparently successful, because ant population decreased undetectable levels within short time. However, construction model for management purposes difficult probability detecting ants...
We evaluated the preference of adult sweetpotato whitefly [SPWF ( Bemisia tabaci biotype B)] to cucumber Cucumis sativus ) seedlings grown under fluorescent lamps (FLs) or metal-halide (MLs) that provided a spectrum similar natural light. Cucumber were FLs MLs at photosynthetic photon flux 350 μmol·m −2 ·s −1 in 12/12-hour light/dark cycle. The red:far red (R:FR) ratio FL was 7.0 and ML 1.2. Pairs seedlings, one other MLs, then placed cages about 100 SPWF adults released. There significantly...
Pesticides are frequently used to eradicate invasive ant species, but pose ecological harm. Previous studies assessed non-target effects only in terms of the increase or decrease abundance species richness after pesticide applications. Positive release from pressure caused by have not been considered so far. To more accurately assess field, pesticides should be separately positive such releases. Here, we monitoring data ants and other invertebrates collected a program for eradication...
The liver, a major organ for drug metabolism, is physiologically similar between monkeys and humans. However, the paucity of identified genes has hampered deep understanding metabolism in monkeys. To provide such genetic resource, 28655 expressed sequence tags (ESTs) were generated from cynomolgus monkey liver full-length enriched cDNA library, which contained 23 unique ESTs homologous to human drug-metabolizing enzymes. Our comparative genomics approach nine lineage-specific candidate ESTs,...
A number of previous studies have revealed the abnormal expression various angiogenesis-related genes or products in brain arteriovenous malformation (AVM). To understand molecular process this disease, we analyzed gene profiles AVM. Using a DNA microarray consisting 17,086 genes, identified differentially expressed 5 AVMs from their draining veins, vessels retaining basic venous architecture. Not many were between AVM nidus and vein. When applied an absolute cut-off value for normalized...
Declines in bee populations, part due to pesticides, especially insecticides, are of global concern. Although most studies have investigated insecticide residues honeybees and bumblebees, few focused on non-Apis solitary bees, which considered essential pollinators the field. Most bees build their nests ground or tree holes, therefore exposure pathways would differ from those bumblebees. We analyzed 20 insecticides Osmia cornifrons pollen-provisions nesting materials, along with adult...
Abstract Zizina emelina (de l'Orza) is listed on Japan's Red Data List as an endangered species because of loss its principal food plant and habitat. We compared parts the mitochondrial nuclear genes this to investigate level genetic differentiation among 14 extant populations. also examined infection butterfly with bacterium Wolbachia clarify bacterium's effects host population's structure. Mitochondrial DNA analyses revealed that haplotype composition differed significantly most...
We developed a loop-mediated isothermal amplification (LAMP) assay to detect the red imported fire ant, Solenopsis invicta Buren, an invasive species in Japan. designed species-specific LAMP primers on basis of nucleotide sequence S. mitochondrial cytochrome c oxidase subunit 1 region. The system we has sensitivity and specificity enabling detection one mixed sample including nine individuals non-target ant species. were easily able DNA visually based turbidity reaction mixture. This rapid...