A5082490159- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Temporomandibular Joint Disorders
- Neurosurgical Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Oral and Craniofacial Lesions
- Vasculitis and related conditions
- Cardiac Valve Diseases and Treatments
- Laser Applications in Dentistry and Medicine
- Aortic aneurysm repair treatments
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Trigeminal Neuralgia and Treatments
- Myasthenia Gravis and Thymoma
- Developmental Biology and Gene Regulation
- Abdominal vascular conditions and treatments
- Genetic Syndromes and Imprinting
Memorial Hospital of South Bend
2025
Kokura Memorial Hospital
2019-2024
Takenaka (Japan)
2019
Kyoto University
2016-2018
Kobe City Medical Center General Hospital
2013-2014
Minneapolis Institute of Arts
2013
Johnson & Johnson (United States)
2013
Boston Scientific (United States)
2013
FX Palo Alto Laboratory
2013
Foundation for Biomedical Research and Innovation
2013
The spinal cord contains more than 20 distinct subclasses of neurons that form well-organized neural circuits capable sensing the environment and generating motor behavior. Although recent studies have described efficient in vitro generation neurons, induction as a whole tissue has not been achieved. In present study, we demonstrate three-dimensional (3D) dorsal cord-like tissues from human pluripotent stem cells. Our 3D (3-DiSC) condition recapitulates patterning developing enables four...
Background and Purpose— The clinical course of acute ischemic stroke with large vessel occlusion (LVO) is a multifactorial process various prognostic factors. We aimed to model this machine learning predict the long-term outcome LVO before endovascular treatment compare our method previously developed pretreatment scoring methods. Methods— derivation cohort included 387 patients, external validation 115 patients anterior circulation who were treated mechanical thrombectomy. statistical...
Background and Purpose— For patients with large vessel occlusion, neuroimaging biomarkers that evaluate the changes in brain tissue are important for determining indications mechanical thrombectomy. In this study, we applied deep learning to derive imaging features from pretreatment diffusion-weighted image data evaluated ability of these predicting clinical outcomes occlusion. Methods— This multicenter retrospective study included anterior circulation occlusion treated thrombectomy between...
Eagle syndrome is a set of symptoms associated with an elongated styloid process. Although it important cause cerebrovascular complications such as carotid artery dissection (CAD) or thromboembolism, the condition may be underdiagnosed. We treated three patients CAD caused by process within year. The first patient was 55-year-old man who developed recurrent thromboembolism despite anticoagulation therapy. Computed tomography (CT) angiography showed bilateral tips processes attached to...
Middle meningeal artery (MMA) embolization has been performed to treat refractory chronic subdural hematoma (CSDH) with good reported outcomes. We have treated three cases of CSDH MMA date, but there was a postoperative recurrence in one patient, which required craniotomy for removal and capsulectomy. blocks the blood supply from dura outer membrane order prevent recurrences CSDH. Histopathologic examination excised during showed foreign-body giant cells neovascular proliferation associated...
The recapitulation of human neural development in a controlled, defined manner from pluripotent stem cells (PSCs) has considerable potential for studies development, circuit formation and function, the construction vitro models neurological diseases. inhibition Wnt signaling, often by recombinant protein DKK1, is important induction cortical neurons. Here, we report novel differentiation method using small-molecule WNT inhibitor, WNT-C59 (C59), to efficiently induce anterior cortex. We...
Few neuro-endocrinological studies have examined the relationship between occlusal disharmony and stress. To determine effect of on central nervous system, we measured plasma corticosterone extracellular noradrenaline in vicinity hypothalamic paraventricular nucleus rats both with without incisal caps. After caps were set, levels gradually increased, reaching a peak at 8.5 6.5 hours, respectively, after which they decreased. Furthermore, increased circadian fashion around onset dark phase...
In patients with ischemic stroke, DWI lesions can occasionally be reversed by reperfusion therapy. This study aimed to ascertain the relationship between ADC levels and reversal in acute stroke who underwent recanalization treatment.We conducted a retrospective cohort endovascular mechanical thrombectomy successful April 2017 March 2021. was assessed through follow-up MR imaging approximately 24 hours after treatment.In total, 118 were included. confirmed 42 patients. The level significantly...
Abstract Perampanel belongs to a novel class of antiseizure medications (ASMs). Studies examining the effect hemodialysis on perampanel serum levels in clinical settings are lacking. We aimed evaluate changes during hemodialysis. studied patients with seizures who received oral between April 2020 and March 2023 whose concentration was measured before after analyzed concentrations levetiracetam lacosamide for comparison. Fourteen patients, mean age 76.1 ± 7.88 years, were included. The dose...
Cavernous internal carotid artery (ICA) aneurysm complicated by simultaneous and spontaneous formation of thromboses in the parent is a rare clinical condition. Although majority patients have good outcomes, some experience severe ischemic stroke. Here, we report case symptomatic large cavernous ICA rapid growth an intra-aneurysmal thrombosis with thrombosis. A 68-year-old female presented sudden-onset diplopia, right ptosis, conjunctival hyperemia, paresthesia face. Magnetic resonance...
Distal superior cerebellar artery (SCA) aneurysms are rare and treated using various treatment strategies. Treatment often requires parent occlusion, which raises concerns regarding the potential risk of ischemia in distal territory.An 81-year-old woman presented with subarachnoid hemorrhage. Diagnostic cerebral angiography revealed two tiny SCA aneurysms. Because significant ischemic damage following occlusion was concerned, bypasses between occipital branches were first performed patient...
三叉神経の機械的刺激により徐脈, 血圧低下や心停止を起こすことがあり, 三叉迷走神経反射と呼ばれる. 今回われわれはテント上未破裂脳動脈瘤クリッピング術中に, 硬膜の刺激による三叉迷走神経反射が原因と思われる心停止をきたした症例を2例経験したので報告する. 代表症例は63歳の女性で, 未破裂動脈瘤に対して開頭クリッピング術を施行した. クリップを脳動脈瘤に近づけた際に, クリップが硬膜に接触したところ4∼5秒間の心停止を2回きたした. 術中操作の中断ですぐに回復し, 手術後の経過は問題なかった. 硬膜刺激による三叉迷走神経反射はすべての開頭手術で起こる可能性があり, テント上未破裂脳動脈瘤クリッピング術でもその頻度は低くない. 生じた場合はすみやかに術中操作を中断することが最も確実な対処法である.
Superficial siderosis is a disease in which hemosiderin deposited under the leptomeninges and subpial layers of hindbrain structures, e.g., cerebellum, brainstem, eighth cranial nerve. The main symptoms superficial are cerebellar ataxia, hearing loss, cognitive decline, myelopathy. activities daily living patients with severely impaired due to progressive symptoms. Here, we report patient whose deteriorated after lumbar subarachnoid-peritoneal (L-P) shunt surgery. She received L-P surgery...
Carotid artery stenting (CAS) has been established as an effective surgical treatment for internal carotid stenosis and/or common (ICAS/CCAS). Typically, CAS is performed via a transfemoral, transbrachial, or transradial approach. However, direct puncture (DP-CAS) preferred in cases where conventional access routes are challenging, such the presence of cervical vascular tortuosity thoracic aortic aneurysm. Since 2020, our institution selectively adopted DP-CAS, utilizing 3D exoscopy through...
Carotid artery stenosis is a significant cause of ischemic stroke, often necessitating interventions like carotid stenting (CAS) to restore adequate blood flow. However, complications intraprocedural arterial dissection can arise during the procedure. This report presents case CAS using CASPER Rx stent. A 77-year-old male, previously diagnosed with asymptomatic right internal (ICA) two years earlier, was presented our institution transient left upper limb paralysis. stent planned due...
Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disorder of the central nervous system caused by opportunistic infection JC virus (JCV).A 58-year-old Japanese woman was admitted to our hospital for aphasia. She had 5-year history untreated sarcoidosis and human T cell lymphotropic virus-1 (HTLV-1) carrier. Serum angiotensin-converting enzyme, soluble interleukin-2 receptor, lysozyme, calcium levels were elevated. JCV-DNA not detected in cerebrospinal fluid PCR...