A5022887062- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Gestational Diabetes Research and Management
- Suicide and Self-Harm Studies
- Potassium and Related Disorders
- Cancer, Lipids, and Metabolism
- HIV/AIDS Research and Interventions
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Global Maternal and Child Health
- Epilepsy research and treatment
- Pain Management and Opioid Use
- Attention Deficit Hyperactivity Disorder
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Topic Modeling
- Pharmacology and Obesity Treatment
- Pancreatic and Hepatic Oncology Research
- Drug-Induced Adverse Reactions
- Natural Language Processing Techniques
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Schizophrenia research and treatment
- Blood Pressure and Hypertension Studies
- Retinal and Optic Conditions
Naval Medical Center Portsmouth
2024
University of Toronto
2009-2023
Hospital for Sick Children
2023
SickKids Foundation
2023
St. Michael's Hospital
2015-2022
Unity Health Toronto
2022
Institute for Clinical Evaluative Sciences
2013-2020
Carleton University
2005-2019
Carleton College
2019
Master's College
2019
To develop and validate a set of practical prediction tools that reliably estimate the outcome subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH).Cohort study with logistic regression analysis to combine predictors treatment modality.Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, hospital registries.Researchers collaborated pool datasets registries, trials SAH multiple...
<h3>Background</h3> Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated of acute kidney injury. We examined the risk injury in a large population older patients receiving PPIs. <h3>Methods</h3> conducted population-based study involving Ontario residents aged 66 years who initiated PPI therapy between Apr. 1, 2002, Nov. 30, 2011. used propensity score matching to establish highly comparable reference group control patients. The primary outcome was hospital...
Suicide is the tenth leading cause of death in United States, and its rate has risen by 16% past decade. Deliberate self-poisoning method attempted suicide. Unlike more violent methods, which are almost universally fatal, survival following common, providing an opportunity for secondary prevention. However, long-term risk suicide a first episode unknown.To determine mortality from other causes episode.Population-based cohort study using multiple linked health care databases. We identified...
<b>Objective:</b> To compare the analgesic efficacy of single and multiple doses ibuprofen with that paracetamol in patients knee or hip osteoarthritis (IPSO study). <b>Method:</b> 222 were randomised a double blind, multicentre study—156 (70%) had painful joint 66 (30%) joint. The main criterion was pain intensity assessment after dose (ibuprofen 400 mg, 1000 mg). Functional disability patient global carried out over 14 days. <b>Results:</b> sum difference 6 hours first administration...
Background Some evidence suggests that proton pump inhibitors (PPIs) are an under-appreciated risk factor for hypomagnesemia. Whether hospitalization with hypomagnesemia is associated use of PPIs unknown. Methods and Findings We conducted a population-based case-control study multiple health care databases in Ontario, Canada, from April 2002 to March 2012. Patients who were enrolled as cases Ontarians aged 66 years or older hospitalized For each individual case, we identified up four...
We aimed to examine pharmacologic, demographic and medical comorbidity risk factors for opioid-related mortality among patients currently receiving methadone an opioid use disorder. conducted a population-based, nested case-control study linking healthcare coroner's records in Ontario, Canada, from January 31, 1994 December 2010. included social assistance recipients Within this group, cases were those who died of causes. For each case, we identified up 5 controls matched on calendar...
<h3>Background:</h3> Trimethoprim–sulfamethoxazole increases the risk of hyperkalemia when used with spironolactone. We examined whether this drug combination is associated an increased sudden death, a consequence severe hyperkalemia. <h3>Methods:</h3> conducted population-based nested case–control study involving Ontario residents aged 66 years or older who received spironolactone between Apr. 1, 1994, and Dec. 31, 2011. Within group, we identified cases as patients died death within 14...
<h3>BACKGROUND:</h3> Dabigatran etexilate is a prodrug whose absorption opposed by intestinal P-glycoprotein and which converted carboxylesterase to its active form, dabigatran. Unlike other statins, simvastatin lovastatin are potent inhibitors of carboxylesterase, might either increase the risk hemorrhage with dabigatran or decrease effectiveness. <h3>METHODS:</h3> We conducted 2 population-based, nested case–control studies involving Ontario residents 66 years age older who started between...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions. Both primarily develop as idiosyncratic responses to drugs,1 resulting in extensive detachment. Recurrence has been reported isolated cases, the overall risk of recurrence is unknown. Given rarity SJS TEN, valid inferences about rates require study large populations over an extended period. We examined long-term following a first or TEN episode.
Background: Intentional overdose is the commonest form of self-harm in adolescents globally. We explored temporal trends intentional among youth.Methods: Using multiple linked healthcare databases, we conducted a population-based cohort study Ontario, Canada, from 2002 to 2015. included all patients aged 8 19 years who presented an emergency department (ED) or were hospitalized for overdose, stratifying by age and agent(s) consumed. determined annual rate over time. For context, contrasted...
BackgroundRecent evidence suggests that proton pump inhibitors (PPIs) might be linked with adverse cardiac events, but a causal relationship is unproven. MethodsWe applied the self-matched case series method to two studies using population-based health care data from Ontario, Canada between 1996 and 2008. The first included subjects aged 66 years or older hospitalized for acute myocardial infarction within 12 weeks following initiation of PPI, while second heart failure. In both we...
The placental weight ratio (PWR) is a health indicator that reflects the balance between fetal and growth. PWR defined as divided by birth weight, it changes across gestation. Its ranges are not well established. We aimed to establish distributions gestational age investigate whether vary growth adequacy, small, average, large for (SGA, AGA, LGA). data came from hospital based retrospective cohort, using all births at two London, Ontario hospitals in past 10 years. All women who delivered...
<h3>Objective:</h3> To examine the trends in antiepileptic drug (AED) use among individuals living Manitoba with and without a history of epilepsy. <h3>Methods:</h3> Using data obtained from administrative health databases Manitoba, we assessed quarterly prevalence AED between 1998 2013 epilepsy using cross-sectional time series analysis. <h3>Results:</h3> Over study period, number prescribed AEDs increased more than 3-fold, 8,883 to 27,246. The patients by 3%, 789.6 per 1,000 1998/1999...
Context: Intentional overdose is a leading method of self-harm and suicide, repeat attempts strongly predict eventual death by suicide.Objectives: To determine the risk recurrence after first intentional overdose. Secondary objectives included characterization temporal course potential predictors overdose, strong factor for from suicide.Methods: Design: Population-based cohort study.Setting: Ontario, Canada, 1 April 2002 to 31 March 2013.Participants: All Ontario residents presenting an...
Among patients taking warfarin, lower socioeconomic status is associated with poorer control of anticoagulation. However, the extent to which influences risk hemorrhage unknown. We examined in older individuals newly commencing warfarin therapy for atrial fibrillation.We conducted a population-based cohort study 66 years or fibrillation who commenced between April 1, 1997, and November 30th 2011, Ontario, Canada. used neighborhood-level income quintiles as measure status. The primary outcome...
Small studies suggest that prescription stimulants can precipitate psychosis and mania. We conducted a population-based case-crossover study to examine whether hospitalization for or mania was associated with initiation of stimulant therapy. Between October 1, 1999 March 31, 2013, we studied 12,856 young people who received were subsequently hospitalized Of these, 183 commenced treatment during 1 2 prespecified 60-day intervals (defined as the "risk interval" "control interval,"...
Knowledge Graph Augmentation is the task of adding missing facts to an incomplete knowledge graph improve its effectiveness in applications such as web search and question answering. State-of-the-art methods rely on information extraction from running text, leaving rich sources tables behind. We help close this gap with a neural method that uses contextual surrounding table Wikipedia article extract relations between entities appearing same row or entity said table. trained tested our much...
<b>Objective</b> To determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour. <b>Design</b> Population based matched cohort study. <b>Setting</b> Multiple validated healthcare databases in Ontario, Canada, 1994-2012. <b>Participants</b> 326 607 men aged 20 to 65 who had undergone were identified through physician billing codes 1:1 on age (within two years), year entry, comorbidity score, geographical region did...