A5052288807- NF-κB Signaling Pathways
- Phagocytosis and Immune Regulation
- Regulation of Appetite and Obesity
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Cancer, Stress, Anesthesia, and Immune Response
- Ginseng Biological Effects and Applications
- Exercise and Physiological Responses
- Inflammation biomarkers and pathways
- Plant-based Medicinal Research
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatitis Pathology and Treatment
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Fuel Cells and Related Materials
- Traditional Chinese Medicine Studies
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Metabolism and Genetic Disorders
- Chromatography in Natural Products
- Chronic Lymphocytic Leukemia Research
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
University of Washington
2024
Zhejiang University
2015
Long Island Jewish Medical Center
2003-2012
North Shore University Hospital
2004-2012
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2012
Feinstein Institute for Medical Research
2011
Albert Einstein College of Medicine
1996
BACKGROUND: Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart failure with reduced ejection fraction. However, their role in the pathogenesis HF preserved fraction (HFpEF) is poorly understood. METHODS: In a mouse model HFpEF, induced by high-fat diet Nω-nitrol-arginine methyl ester, cardiac energetics was measured 31 P NMR spectroscopy substrate oxidation profile assessed 13 C-isotopmer analysis. Mitochondrial functions were tissue human pluripotent stem cell–derived...
Our previous studies have shown that norepinephrine (NE) upregulates proinflammatory cytokines by activating α2A-adrenoceptor. Therefore, modulation of the sympathetic nervous system represents a novel treatment for sepsis. We also stomach-derived peptide, ghrelin, is downregulated in sepsis and its intravenous (IV) administration decreases improves survival. This beneficial effect appears to be mediated through central system, as evidenced inhibitory intracerebroventricular ghrelin on...
Coptidis Rhizoma and Aconiti Kusnezoffii Radix represent hot Chinese medicine cold respectively. The purpose of this study is to observe the differentiation effect on lewis lung cancer compare tumor progression. In study, rat serum containing or was prepared treat cells in vitro, effects cell differentiation, proliferation, adhesion, succinic dehydrogenase (SDH) activity gap-junction intercellular communication (GJIC) were investigated. vivo, subcutaneous implant model pulmonary metastasis...
Miksa, M., R. Wu, W. Dong, H. Komura, D. Amin, Y. Ji, Z. Wang, T. S. Ravikumar, K. J. Tracey, and P. Wang. 2009. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor VIII. [ Immunol. 183: 5983–5990][1] . The title of this article
The high mortality of sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF) and late HMGB1) pro-inflammatory cytokines. Our discovery HMGB1 as a mediator lethal systemic inflammatory diseases has initiated new field investigation for development experimental therapeutics. A popular Chinese herb, Angelica sinensis (also known Dang Gui or Dong Quai) been used traditionally treating women with gynecological disorders...
Clearance of apoptotic cells is crucial in sepsis. We have previously shown that administration immature dendritic cellderived exosomes containing milk fat globule epidermal growth factor-factor VIII (MFG-E8) to septic animals promoted phagocytosis and improved survival. MFG-E8 an opsonin for acts as a bridging protein between phosphatidylserine on integrins phagocytes. Fractalkine (Fr) CX3C-chemokine (both chemoatractant adhesion molecule) upregulated by proinflammatory cytokines has been...
PDI is important for the protein modification step in posttranslation and plays an essential role cell survival under stress conditions. has been reported as a negative regulator of NF-κB can inhibit cytokine production RAW cells after LPS stimulation, suggesting that may serve intracellular anti-inflammatory molecule. Our previous data showed Kupffer cell-derived proinflammatory cytokines cause liver injury sepsis. However, effect sepsis on expression not investigated. We therefore...