A5057425369- RNA and protein synthesis mechanisms
- Fractal and DNA sequence analysis
- Chronic Lymphocytic Leukemia Research
- Genetic Associations and Epidemiology
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- Psychosomatic Disorders and Their Treatments
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- Genetic Mapping and Diversity in Plants and Animals
- Mental Health and Psychiatry
- Cellular Automata and Applications
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Genomics and Chromatin Dynamics
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Crystallization and Solubility Studies
- Complex Systems and Time Series Analysis
Feinstein Institute for Medical Research
2016-2025
Northwell Health
2016-2025
Stony Brook University
2023-2025
Shanghai East Hospital
2025
Fu Wai Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
State Key Laboratory of Food Science and Technology
2024-2025
Jiangnan University
2024-2025
Soochow University
2025
Soochow University
2025
Rheumatoid arthritis is a chronic inflammatory disease with substantial genetic component. Susceptibility to has been linked region on chromosome 2q.We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously 2q for association rheumatoid arthritis. We then performed fine mapping of STAT1-STAT4 total 1620 case patients established 2635 controls, all from North America. Implicated SNPs were further an independent case-control series 1529 early 881...
Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1 and PTPN22 are well-established susceptibility loci, other genes that confer modest level risk have been identified recently. We carried out genomewide association analysis to identify additional genetic loci associated with an increased rheumatoid arthritis.
It is shown that the distribution of word frequencies for randomly generated texts very similar to Zipf's law observed in natural languages such as English. The facts frequency occurrence a almost an inverse power function its rank and exponent this close 1 are largely due transformation from word's length rank, which stretches exponential function.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mutual information function, which is an alternative to correlation function for symbolic sequences, and a "symbolic spectrum" are calculated human DNA sequence containing mostly intron segments, those that do not code proteins. It observed the mutual of this decays very slowly, length extremely long (at least 800 bases). The spectrum at low frequencies can be approximated by 1/fα, where f frequency α ranges from 0.5 0.85. suggested existence repetitive patterns in mainly responsible...
The t-distributed stochastic neighbor embedding t-SNE is a new dimension reduction and visualization technique for high-dimensional data. rarely applied to human genetic data, even though it commonly used in other data-intensive biological fields, such as single-cell genomics. We explore the applicability of data make these observations: (i) similar previously techniques principal component analysis (PCA), able separate samples from different continents; (ii) unlike PCA, more robust with...
Background Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and characterized by unpredictable flares of disease. Recent evidence indicates role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects IFN pathway activation are not well understood. Here we test hypothesis IFN-regulated proteins present serum patients correlate with disease activity. Methods Findings We performed comprehensive survey...
Abstract Objective To examine the association between HLA–DRB1 alleles and production of anti–cyclic citrullinated peptide (anti‐CCP) rheumatoid factor (RF) autoantibodies in patients with arthritis (RA). Methods We studied 1,723 Caucasian RA enrolled North American Rheumatoid Arthritis Consortium (NARAC) family cohort Study New Onset (SONORA) cohort. All were tested for anti‐CCP antibodies (by enzyme‐linked immunosorbent assay), RF nephelometry), HLA–DR genotype polymerase chain reaction...
The prediction of response (or non-response) to anti-TNF treatment for rheumatoid arthritis (RA) is a pressing clinical problem. We conducted genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning therapy as part Autoimmune Biomarkers Collaborative Network (ABCoN [Autoimmune Bio-markers Network]) patient cohort. Response was determined by change in Disease Activity Score (DAS28) observed 14 wks. used two-part analysis that...
There are 512 two-locus, two-allele, two-phenotype, fully penetrant disease models. Using the permutation between two alleles, loci, and being affected unaffected, one model can be considered to equivalent another under corresponding permutation. These permutations greatly reduce number of two-locus models in analysis complex diseases. This paper determines nonredundant (which 102, 100, 96, 51, 50, or 58, depending on which used, whether zero-locus single-locus excluded). Whenever possible,...
Insulin-dependent diabetes mellitus (IDDM) is associated with elevated plasma triglyceride levels that normalize after insulin administration. The observation overexpression of the apoC-III gene in transgenic mice can cause hypertriglyceridemia and other evidence implicating regulation prompted us to examine whether might be involved IDDM. To this end, expression was studied streptozotocin-treated mouse model In insulin-deficient diabetic state, these have glucose a 1.4- 1.5-fold increase...
Abstract The failure of chemotherapeutic regimens to eradicate cancers often results from the outgrowth minor subclones with more dangerous genomic abnormalities or self-renewing capacity. To explore such intratumor complexities in B-cell chronic lymphocytic leukemia (CLL), we measured kinetics vivo by quantifying deuterium ( 2 H)-labeled cells as an indicator a cell that had divided. Separating CLL clones on basis reciprocal densities chemokine (C-X-C motif) receptor 4 (CXCR4) and cluster...
The brain represents sensory information in the coordinated activity of neuronal ensembles. Although microcircuits underlying olfactory processing are well characterized <i>Drosophila</i>, no studies to date have examined encoding odor identity by populations neurons and related it specificity behavior. Here we used two-photon Ca<sup>2+</sup> imaging record odor-evoked responses from >100 simultaneously <i>Drosophila</i> mushroom body (MB). For first time, demonstrate quantitatively that...
Patients with early-stage Alzheimer's disease exhibit perceptual deficits in odour identification, often before the appearance of overt memory loss. This impairment coincides initial accumulation pathological lesions limbic olfactory brain regions. Although these data imply that stimuli may be effectively used as biological probes dysfunction, precise neural mechanisms underlying early remain poorly understood. In current study, we combined functional magnetic resonance imaging an...
Abstract Human Ab-secreting cell (ASC) populations in circulation are not well studied. In addition to B-1 (CD20+CD27+CD38lo/intCD43+) and conventional plasmablast (PB) (CD20-CD27hiCD38hi) populations, this study, we identified a novel B population termed 20+38hi cells (CD20+CD27hiCD38hi) that spontaneously secretes Ab. At steady-state, distinct from PBs on the basis of CD20 expression, amount Ab production, frequency mutation, diversity BCR repertoire. However, cytokine treatment induces...