Blood oxygen level-dependent (BOLD) functional MRI (fMRI) is a standard approach to examine resting state connectivity (RSFC), but fMRI in animal models challenging. Recently, optical intrinsic signal imaging—which relies on the same hemodynamic underlying BOLD fMRI—has been developed as complementary assess RSFC mice. Since it difficult ensure that an truly while awake, measurements under anesthesia remain important approach. Therefore, we systematically examined measures of using...

Objectives: Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is a leading monogenic cause of cerebral small-vessel disease. This study aimed to evaluate the functional integrity long white matter tracts in CADASIL transgenic mice assess potential tocotrienol (T3) as therapeutic agent. Methods: Optical resting-state connectivity imaging behavioral examinations were employed characterize mice, both with without focal lesions corpus callosum....

Introduction: Neuroanatomy-based functional examinations are crucial for understanding the extent and effects of infarcts in stroke studies. Despite importance correlating neurological function with brain anatomy, a comprehensive score that correlates infarction volume location following middle cerebral artery occlusion (MCAO) mice is lacking. During pilot phase Stroke Preclinical Assessment Network (SPAN), new scoring system—SPAN score—was developed. This study aims to evaluate reliability...

Introduction: Ischemic stroke is a leading cause of death and disability worldwide, but there has been limited success in translating putative treatments from preclinical trials to patients. The Stroke Preclinical Assessment Network (SPAN) large-scale multicenter trial (six sites plus coordinating center). Methods: SPAN implemented multiparametric MRI protocol with minimal human input assess tissue outcomes after mouse endovascular middle cerebral artery occlusion (MCAO). Imaging 1766 mice...

Collateral development plays an important role in maintaining cerebral blood flow (CBF) the presence of critical stenosis or occlusion large arteries. Age is a non-modifiable risk factor for ischemic stroke associated with collateral rarefaction. Here, we studied influence aging on and hemodynamic impairment using 114 mice (56 male 58 female, C57/BL6) two age groups (young: 20 ± 2 weeks; aged: 71 9 weeks). We permanently occluded right common carotid artery (RCCAO) via suture ligation...

Introduction: The rapid recanalization of occluded vessels and the restoration cerebral blood flow (CBF) are critical for outcome stroke. Patients may exhibit poor reperfusion (no-flow) or hyperperfusion (hyperemia) after recanalization, factors influencing these conditions not fully understood. Stroke Preclinical Assessment Network (SPAN) conducted a randomized, controlled, blinded, highly heterogeneous multi-laboratory trial to identify effective interventions in stroke animal model. Here,...

Background: Cerebral autosomal-dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most prevalent monogenic inherited cause of cerebral small-vessel disease. Despite its prevalence, there currently no proven therapy to prevent or reverse progression Methods: This study aimed characterize functional integrity long white matter tracts in CADASIL transgenic mice, both with without focal lesions corpus callosum added on, utilizing optical resting-state...

Aneurysmal subarachnoid hemorrhage (SAH) leads to significant long-term cognitive deficits, which can be associated with alterations in resting state functional connectivity (RSFC). However, modalities such as fMRI—which is commonly used assess RSFC humans—have practical limitations small animals. Therefore, we non-invasive optical intrinsic signal imaging determine the effect of SAH on mice up three months after prechiasmatic blood injection. We assessed Morris water maze (MWM), open field...

Spreading depolarizations (SDs) are recurrent and ostensibly spontaneous depolarization waves that may contribute to infarct progression after stroke. Somatosensory activation of the metastable peri-infarct tissue triggers SDs at a high rate.

The aim of this study was to assess validity and reliability the Turkish version expanded revised Short-Form McGill Pain Questionnaire (TR-SF-MPQ-2) in patients with chronic low back pain (CLBP) investigate relationship between TR-SF-MPQ-2 etiology, scales, disability index.Between October 2014 December 2014, a total 194 CLBP (66 males, 128 females; mean age 50±14.3 years; range, 35 65 years) attending our outpatient clinic were included. To reliability, Cronbach alpha (α) intraclass...

Introduction: Stroke-related factors seem to have significant effects on sexual functions in physical, biological, and psychosocial areas. This study aims evaluate the affecting of patients after stroke.
 Material- methods: consisted 51 (53.1%) male 45 (46.9%) female patients. Socio -demographics clinical features were documented. Sexual evaluated with Arizona Experiences Scale (ASES), International Index Erectile function (IIEF) Female Function (FSFI).
 Results: The mean age men...

To investigate the impact of subarachnoid hemorrhage (SAH) on neuronal and hemodynamic measures resting state functional connectivity after SAH assess its correlation with behavioral deficits.

To study the effect of unilateral cortical spreading depolarizations (CSD) on resting state functional connectivity (RSFC).

Abstract Aneurysmal subarachnoid hemorrhage (SAH) leads to significant long-term cognitive deficits. Studies in survivors of SAH show an association between persistent deficits and alterations resting state functional connectivity (RSFC). However, modalities commonly used assess RSFC humans, such as fMRI, have practical limitations small animals. Therefore, we non-invasive optical intrinsic signal imaging determine the effect on measures mice at early (day 4), intermediate (1 month), late (3...

Subcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on functional recovery after focal injury.A corpus callosum lesion was induced by stereotactic injection of N5-(1-iminoethyl)-L-ornithine mice. Fasudil (10 mg/kg) or vehicle administered daily for 2 weeks, starting one day induction. Resting-state connectivity grid walk performance were...

Abstract The corpus callosum is the largest white matter tract and critical for interhemispheric connectivity. Unfortunately, neurocognitive deficits after experimental lesions are subtle variable, limiting their translational utility. We examined resting state functional connectivity (RSFC) as a surrogate focal lesion in lateral induced by stereotaxic injection of L-NIO mice. RSFC was performed via optical intrinsic signal imaging through intact skull before on days 1 14 injection, using...

A Am ma aç ç: : Diz osteoartrit (OA) tanılı hastalarda serum 25 hidroksivitamin D [25(OH)D] düzeyi ile diz fonksiyonu, kas gücü ve yaşam kalitesi arasındaki ilişkiyi değerlendirmektir.G Ge er re eç ç v e Y Yö ön nt te em ml le r: Amerikan Romatoloji Koleji (ACR) kriterlerine göre OA tanısı alan 99 hasta çalışmaya dâhil edildi.Hastalar 25(OH)D düzeyine 20 ng/mL'den düşük olanlar 1. grubu, 21-29 ng/mL arasında 2. grubu 30 yüksek 3. oluşturmak üzere üç gruba ayrıldı.Hastaların beden kitle...

OBJECTIVES: The aim of this study is to investigate the effects factors such as age, gender, comorbid diseases and treatments applied on positive duration PCR test in COVID-19 patients.Background: positivity patients varies.Studies literature investigating that may affect are limited.METHODS: Between March September 2020, individuals with two or more results a 14-day interval were included case group, those whose turned negative within 14 days control group.The relationship between contact...

Objective: The aim of this study was to determine the roles diabetes mellitus (DM) on quality life, function knee, and muscle strength in patients with knee osteoarthritis (OA).
 Material Method: This single-center, case-control prospectively enrolled outpatients OA visiting a physical therapy rehabilitation clinic. were grouped according presence DM diagnosis. Demographic data, disease duration, medical treatments recorded. Clinical parameters, radiographic grading (Kellgren-Lawrence...

Objective: In this study, we examined the factors affecting psychological symptoms and quality of life caregiver parents cerebral palsy patients. Methods: This cross-sectional study was conducted between May-September 2013 in fifty CP patients their caregivers. Demographic information, parents' education, family type, households, patients' siblings, drug usage, rehabilitation hospitalizations (NoRH), gross motor function levels were recorded. The caregivers completed psychometric symptom...

Hip fracture is one of the most common fractures among elderly population with high rates mortality and morbidity. The annual incidence hip predicted to be increased by around 16 times year 2050. Due cost traditional rehabilitation after surgery effect pandemics, telerehabilitation gaining more importance in recent years. This review designed examine progress surgery. PubMed/MEDLINE, Scopus, Web Science for English-language sources were searched from their inception using keywords between...

Amaç: Spinal kord yaralanması (SKY) sonrası parapleji tanısı almış, omuz ağrısı olan ve yardımcı cihaz ya da tekerlekli iskemle (Tİ) kullanan hastalarda, lezyonlarının klinik ultrasonografik (US) olarak incelenmesi bunların nörolojik seviye, cinsiyet, SKY süresi ile ilişkisinin belirlenmesidir. Gereç Yöntemler: Çalışmaya alınan 66 hastanın yaş, süresi, etiyoloji ambulasyon seviyesi belirlendi. Ağrı vizüel analog skalası (VAS) değerlendirildi. Nörolojik seviye belirlenirken en son 2011...

Objective: The cut-off value of serum 25(OH)D level for bone-skeletal and cardiovascular diseases are well defined. However, there is no current study defining the optimal levels preventing diabetic distal symmetric polyneuropathy (DSP). We aimed to evaluate relationship between parameters electrophysiology Toronto Clinical Scoring System (TCSS) obtain a in DSP patients. Methods: This case-control included 90 patients with or without diagnosed who were visiting outpatient Physical Therapy...