A5035839283- Inflammatory mediators and NSAID effects
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Phytochemicals and Antioxidant Activities
- Advancements in Transdermal Drug Delivery
- Gastric Cancer Management and Outcomes
- Phytoestrogen effects and research
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Inflammasome and immune disorders
- Drug-Induced Adverse Reactions
- Immune Cell Function and Interaction
- Plant Molecular Biology Research
- Natural Antidiabetic Agents Studies
- Skin Protection and Aging
- Sphingolipid Metabolism and Signaling
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Ginger and Zingiberaceae research
- Biochemical Analysis and Sensing Techniques
- Plant Parasitism and Resistance
- Advanced Glycation End Products research
- Cancer, Lipids, and Metabolism
Oryza (Japan)
2015-2024
Children's Medical Center
2023
Osaka City University
2013-2016
Shizuoka University
2014
Otsu Municipal Hospital
2012
Yokohama National University
2011
Tsumura Research Institute (Japan)
1990-2005
Abstract The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles the NLRP3 inflammasome in pathogenesis ulcerative colitis (UC). After induction oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Histological studies performed on inflamed tissue from mice patients. severity murine peaked day 1, accompanied by an increase expression Th2 cytokines including IL-4 IL-13. Oxazolone treatment...
Abstract Rings or arcs of fungus‐stimulated plant growth occur worldwide; these are commonly referred to as “fairy rings”. In 2010, we discovered 2‐azahypoxanthine (AHX), a compound responsible for the fairy‐ring phenomenon caused by fungus; AHX stimulated all plants tested. Herein, reveal isolation and structure determination common metabolite in plants, 2‐aza‐8‐oxohypoxanthine (AOH). is chemically synthesized from 5‐aminoimidazole‐4‐carboxamide (AICA), can be converted into AOH xanthine...
The inflammasome is a large, multiprotein complex that consists of nucleotide-binding oligomerization domain-like receptor (NLR), an apoptosis-associated speck-like protein containing caspase recruitment domain, and pro-caspase-1. Activation the results in cleavage pro-caspase-1 into cleaved caspase-1, which promotes processing pro-interleukin (IL)-1β mature IL-1β. We investigated effects colchicine on non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury activation...
We previously reported that polymethoxyflavones (PMFs) in black ginger (Kaempferia parviflora) extract (KPE) increased energy production by activating AMP-activated protein kinase (AMPK) C2C12 myoblasts. herein evaluated the effects of KPE on physical fitness performance and muscular endurance mice. Male mice were orally administered for 4 weeks, then forced swimming test, open-field inclined plane wire hanging test performed. significantly time, motility after swimming, grip strength. IL-6...
High-mobility group box 1 (HMGB1) was initially discovered as a nuclear protein that interacts with DNA chromatin-associated non-histone to stabilize nucleosomes and regulate the transcription of many genes in nucleus. Once leaked or actively secreted into extracellular environment, HMGB1 activates inflammatory pathways by stimulating multiple receptors, including Toll-like receptor (TLR) 2, TLR4, for advanced glycation end products (RAGE), leading tissue injury. Although HMGB1's ability...
Ampelopsis grossedentata (AG) is an ancient medicinal plant that mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, anti-inflammatory activities, reductions blood pressure cholesterol hepatoprotective effects. Researchers China recently reported the anti-obesity effects of AG extract diet-induced obese mice rats. To verify these findings, we herein investigated its principal compound, ampelopsin, high-fat diet (HFD)- alcohol...
The activation of peroxisomeproliferator-activated receptor (PPAR) α can stimulate the expression ceramide-related enzymes, and a major component strawberry seed extract (SSE) tiliroside enhances PPARα. We determined whether SSE may ceramide synthesis in stratum corneum (SC) human epidermal equivalents (HEEs) culture model. Treatment with at 1.0 3.0 μg/mL elicited significant increase total content SC, which was accompanied by almost all species except for [EOS] [AP]. 0.3 slightly...
Circadian rhythms play key roles in the regulation of physiological and behavioral systems including wake-sleep cycles. We evaluated effects passionflower (aerial parts Passiflora incarnata Linnaeus) extract (PFE) on circadian using NIH3T3 cells mice. PFE (100 μg/mL) induced high-amplitude expression period protein (Per) 2, cryptochrome (Cry) 1, superoxide dismutase (SOD) glutathione peroxidase (GPx) vitro from 12 h after a treatment with serum-rich medium. Isovitexin 2"-O-glucoside,...
Tomato seeds contain steroidal saponins called lycoperosides. However, it currently remains unclear whether lycoperosides exert anti-inflammatory or anti-allergic effects. Therefore, we herein investigated the effects of tomato seed extract (TSE) and lycoperoside H (LH) in Interleukin (IL)-33 transgenic mice. TSE (500 mg/kg) LH (10 was orally administered once a day for 101 days then evaluated mouse behavior, skin symptoms, blood inflammatory cytokines. slightly suppressed scratching while...
Toll-like receptor 2 (TLR2) recognizes conserved molecular patterns associated with both gram-negative and gram-positive bacteria, detects some endogenous ligands. Previous studies demonstrated that in ischemia-reperfusion (I/R) injury of the small intestine, TLR2-dependent signaling exerted preventive effects on damage young mice, but did not have a significant effect neonatal mice. We investigated role TLR2 adult intestine. Wild-type knockout mice at 16 weeks age were subjected to...
β-Sitosterol 3- O - d -glucoside (BSG) is known to act as an agonist by binding estrogen receptors, and has been reported enhance the activity of β-glucocerebrosidase, epidermal ceramide metabolizing enzyme. In this study, we determined whether BSG up-regulates levels in stratum corneum (SC) a reconstructed human keratinization (RHEK) model. Treatment with significantly increased total content 1.2-fold compared that control SC RHEK model, accompanied significant increase species, Cer[EOS]...
Background and objective: The ingestion of plant-derived glucosylceramides (GlcCer) has been reported to contribute skin barrier function hydration the epidermis. b-sitosterol glucoside (BSG) colocalized with GlcCer in rice hydrophobic fraction shown increase ceramides stratum corneum vitro. Although clinical studies demonstrated that reduced transepidermal water loss (TEWL), contribution BSG epidermal dehydration when applied remains unknown. Therefore, we herein conducted a trial on...
Glucosylceramides (GlcCer), which are present in many edible plants, suppress melanin production mouse melanocytes. Rice GlcCer consist of multiple molecules that comprise different types sphingoid bases as well diverse lengths and stereotypes free fatty acids. Adjacent to the fraction, there ceramides (Cer) minor constituents. However, anti-melanogenic activities individual Cer remain unknown. Therefore, we herein isolated 13 elasticamide, a [AP] from gummy by-products rice bran oil,...
Tomatoes are widely consumed, however, studies on tomato seeds limited. In this study, we isolated 11 compounds including saponins and flavonol glycosides from evaluated their effects epidermal hydration. Among the compounds, seed (10 µM) significantly increased mRNA expression of proteins related to hydration, filaggrin, involucrin, enzymes for ceramide synthesis, by 1.32- 1.91-fold compared with control in HaCaT cells. Tomato also decreased transepidermal water loss 7 13 g/m2·h...
Prostaglandin (PG) E2 promotes gastrointestinal carcinogenesis and tumor progression. The total amount of biologically active PGE2 in tissues is determined by a balance PG biosynthesis degradation pathways, which involve the transporter (PGT). We investigated PGT gastric adenocarcinoma determining its expression pattern examining associations with prognosis angiogenesis.PGT was immunohistochemistry advanced specimens obtained from 96 patients who underwent surgical resection. Correlations...
Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius by using behavioral morphological analyses, Western blotting, a murine model immobilization-induced atrophy. Daily oral FRGE administration increased weight strength. addition, myofiber size FRGE-treated mice was as revealed quantification. Activation AMP-activated protein kinase (AMPK)...
Background: Glucosinolates from brassica plants are hydrolyzed by internal or salivary myrosinase to produce isothiocyanates. Glucoraphanin, a major glucosinolate in broccoli, is sulforaphane (SFN), which exhibits antitumor and detoxification activities. Regarding the influence of broccoli its constituents on skin, few studies have reported anti-inflammatory antioxidant effects. Recently, advanced glycation end products (AGEs) carbonyl proteins been accelerate skin aging. Objective: We...
Ceramide (Cer) plays an important role in skin barrier functions the stratum corneum (SC). The ingestion of food-derived glucosylceramides (GlcCer) attenuates transepidermal water loss (TEWL). However, moisturizing effects single molecules GlcCer and Cer remain unclear. Therefore, we herein purified 13 6 Cer, including elasticamide, which has same structure as human Cer[AP], from rice compared their epidermal a reconstructed keratinization model. results obtained showed that 10 µM 5...