Megumi Takagi

ORCID: 0000-0002-0627-3742
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About
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Research Areas
  • Helicobacter pylori-related gastroenterology studies
  • Gastrointestinal disorders and treatments
  • Gastric Cancer Management and Outcomes
  • Neonatal Health and Biochemistry
  • Vascular Malformations and Hemangiomas
  • Gastrointestinal motility and disorders
  • Gastrointestinal Tumor Research and Treatment
  • Gastroesophageal reflux and treatments
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Pancreatitis Pathology and Treatment
  • Neuroendocrine Tumor Research Advances
  • Esophageal and GI Pathology
  • Liver Diseases and Immunity
  • Venous Thromboembolism Diagnosis and Management
  • Vascular anomalies and interventions
  • Central Venous Catheters and Hemodialysis
  • Liver Disease Diagnosis and Treatment
  • Cholesterol and Lipid Metabolism
  • Inflammatory Biomarkers in Disease Prognosis
  • Hemostasis and retained surgical items
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Nephrotoxicity and Medicinal Plants
  • Neurological Complications and Syndromes
  • CAR-T cell therapy research
  • Potassium and Related Disorders

Saiseikai Nakatsu Hospital
2019-2024

Nagoya Kyouritsu Hospital
2021-2024

Dokkyo Medical University
2022

Nerima General Hospital
2015-2016

Tokyo National Hospital
1966-1970

Okayama University
1967-1968

Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers.

10.1002/ueg2.12557 article EN cc-by-nc-nd United European Gastroenterology Journal 2024-03-07

Summary Background Vonoprazan, a potassium‐competitive acid blocker, is used for acid‐related diseases. Occasionally, small white protrusions called “stardust” gastric mucosa have been detected in the stomachs of some patients taking vonoprazan. Aims To determine incidence of, and risk factors for, stardust potentially induced by vonoprazan Methods In this study, we enrolled 19 503 who underwent endoscopy at our hospital between 2016 2019. Using propensity score matching, retrospectively...

10.1111/apt.16151 article EN Alimentary Pharmacology & Therapeutics 2020-11-07

<b><i>Introduction:</i></b> Lubiprostone is an effective treatment of chronic constipation (CC). However, as with other stimulant or osmotic laxatives, adverse events (AEs) can make it difficult to continue treatment. This article investigates AE risk factors associated lubiprostone. <b><i>Methods:</i></b> We retrospectively analyzed all 1,338 Japanese patients CC treated at our hospital from October 2013 July 2017. All were diagnosed defined...

10.1159/000508864 article EN Digestive Diseases 2020-05-25

<b><i>Introduction:</i></b> Elobixibat is a new laxative, but its efficacy and adverse events (AEs) are insufficiently examined compared with those of other laxatives. Hence, by propensity score (PS) matching, we the effects AEs between elobixibat lubiprostone. <b><i>Methods:</i></b> We retrospectively analyzed 1,887 Japanese patients chronic constipation (CC) treated at our hospital October 2013 April 2020. Enrolled were divided into three...

10.1159/000512745 article EN Digestive Diseases 2020-11-03

Recombinant thrombomodulin (rhTM) is potentially effective in the treatment of disseminated intravascular coagulation (DIC). Several studies related to drugs for acute cholangitis have shown negative results improvement overall survival (OS) with rhTM. The aim this multicenter study was evaluate clinical effectiveness rhTM patients and sepsis-induced DIC who underwent biliary drainage.A total 284 consecutive patients, were complicated due severe cholangitis, included (rhTM group, n = 173;...

10.1002/jhbp.998 article EN Journal of Hepato-Biliary-Pancreatic Sciences 2021-05-22

Liver X receptors (LXRs) are nuclear with various functions, including the regulation of cholesterol metabolism, glucose homeostasis, and inflammation. We previously reported that LXR activation inhibits growth oral cancer cells by inducing cellular efflux LXRβ is expressed mainly in small-cell lung (SCLC) tissues. SCLC one most aggressive cancers, identifying an effective therapeutic target molecule desirable. Therefore, we investigated whether could be for treatment through vitro...

10.21873/anticanres.15774 article EN Anticancer Research 2022-05-31

Gastric submucosal tumors (SMTs) are occasionally observed on gastrointestinal endoscopy. Ectopic pancreas is a rare but important entity. In this case report, we describe the of 21-year-old female patient who presented with frequent vomiting after meals and was found to have giant gastric SMT causing outlet obstruction. Upper endoscopy, radiography, plain computed tomography (plain CT), contrast-enhanced (CE-CT), abdominal ultrasound magnetic resonance imaging (MRI) showed cystic lesion in...

10.11641/pde.104.1_68 article EN Progress of Digestive Endoscopy 2024-06-21

Abstract Background and Aim Elobixibat is a triple mode of action laxative that increases water secretion into the colon, promotes colonic motility, reestablishes defecation desire. This study aims to evaluate effectivity safety elobixibat in chronic constipation (CC) patients refractory conventional laxatives. Methods A single‐center retrospective observational was conducted CC diagnosed according Rome IV criteria received between April 2018 June 2022 at Osaka Saiseikai Nakatsu Hospital....

10.1002/jgh3.70019 article EN cc-by JGH Open 2024-08-01

Esophageal endoscopic submucosal dissection (ESD) is often technically difficult due to intraoperative body movements. The level of sedation can be increased suppress movements, but this may not successful in all cases. Using local analgesics for injection during ESD aid conscious sedation. This study evaluated the feasibility lidocaine method (LIM) esophageal ESD.Twenty-nine patients with superficial cancer were enrolled at Osaka Saiseikai Nakatsu Hospital, and 1% + 0.4% hyaluronate sodium...

10.1002/jgh3.12257 article EN cc-by JGH Open 2019-09-06

A 77-year-old woman was admitted because of a positive fecal test for occult blood. She had taken oral Kamishoyosan continuously 25 years. Colonoscopy revealed dark purplish-blue mucosa from the ileocecum to ascending colon. Histopathology thickened wall colon, with linear calcification mesenteric vein. Based on these findings, patient diagnosed as having idiopathic phlebosclerosis. repeat colonoscopy performed 13 months after discontinued showed improvement color and vascularity colonic...

10.11641/pde.86.1_186 article EN Progress of Digestive Endoscopy 2015-01-01

10.1016/j.cgh.2020.11.030 article EN Clinical Gastroenterology and Hepatology 2020-11-20

Endocrine secretory granules (ESGs) are morphological characteristics of endocrine/neuroendocrine cells and store peptide hormones/neurotransmitters. ESGs contain prohormones ESG-related molecules, mainly chromogranin/secretogranin family proteins. However, the precise mechanism ESG formation has not been elucidated. In this study, we experimentally induced in non-neuroendocrine lung cancer cell line H1299. Since repressive element 1 silencing transcription factor (REST) prospero homeobox...

10.1007/s10735-021-10055-5 article EN cc-by Journal of Molecular Histology 2022-01-30

Colonic muco-submucosal elongated polyps (MSEPs) are a new clinical entity first reported in 1994. The existence of long and slender polypoid lesion like an MSEP the duodenum is rare. A 76-year-old man who complained epigastralgia was diagnosed via endoscopy as having polyp with head part resembling half-sized sumo referee’s fan.. Endoscopic polypectomy snaring technique performed after injection epinephrine-saline into neck polyp. Bleeding from exposed blood vessels controlled clips....

10.11641/pde.88.1_116 article EN Progress of Digestive Endoscopy 2016-01-01

A 72-year-old female was referred to our hospital because of melena. She had been diagnosed as having the Klippel-Trenaunay-Weber syndrome at age 55. Amputation right lower extremity, and a wide resection stomach for duodenal ulcer carried out 61. contrast-enhanced abdominal CT showed obstruction main portal vein, prominent dilatation inferior mesenteric varices rectum. Colonoscopy revealed severe extending from descending colon We considered that blood flow changed course via internal iliac...

10.11641/pde.86.1_190 article EN Progress of Digestive Endoscopy 2015-01-01

10.1007/bf02827157 article EN Gastroenterologia Japonica 1968-06-01

10.1007/bf02801429 article EN Gastroenterologia Japonica 1967-03-01
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