A5103158836- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Metastasis and carcinoma case studies
- Renin-Angiotensin System Studies
- Orthopedic Surgery and Rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Receptor Mechanisms and Signaling
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Neuroscience and Neuropharmacology Research
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Medication Adherence and Compliance
- Biochemical Analysis and Sensing Techniques
- Cardiac Valve Diseases and Treatments
- Biochemical effects in animals
Tokushima Red Cross Hospital
2009-2024
Komatsu (Japan)
2009-2024
Janssen (Belgium)
2024
Shizuoka City Shimizu Hospital
2007-2020
Ise Red Cross Hospital
2016-2019
Red Cross Hospital
1987-2015
Krankenhaus vom Roten Kreuz
1987-2015
Kyoto first Red Cross hospital
2014
Japanese Red Cross Fukuoka Hospital
1996-2014
Kyushu University
2000-2012
Summary Endothelium-dependent relaxations are achieved by a combination of endothelium-derived prostacyclin (PGI2), nitric oxide (NO), and hyperpolarizing factor (EDHF). However, it remains to be fully clarified whether the relative contribution these three mechanisms endothelium-dependent varies as function vessel size. This study was designed clarify this point. Acetylcholine (ACh)-induced were examined in isolated blood vessels taken from aorta proximal distal mesenteric arteries rat. The...
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance endothelium-derived relaxing factor and contracting factor. However, the role hyperpolarization remains undetermined. We examined ACh-induced its contribution arteries SHR. Membrane potentials were recorded from mesenteric artery trunk 6-8-month-old male SHR also Wistar-Kyoto (WKY) rats. Endothelium-dependent ACh was unaffected by...
Ghrelin is an orexigenic peptide originally isolated from the stomach. Intravenous administration of ghrelin has been shown to elicit a decrease in arterial pressure without significant change heart rate (HR), suggesting that may act on central nervous system modulate sympathetic activity. The aim present study was determine effects cardiovascular and responses conscious rabbits. injection elicited dose-related decreases HR, renal nerve On other hand, intracerebroventricular 1 nmol decreased...
Ghrelin is an orexigenic peptide originally isolated from the stomach. Intracerebroventricular administration of ghrelin has been shown to elicit decreases in arterial pressure and renal sympathetic nerve activity conscious rabbits. The aim present study was determine role brain stem cardiovascular responses rats. Unilateral microinjection into nucleus solitary tract significantly decreased mean heart rate (-17.3+/-0.8 mm Hg -13.6+/-3.5 bpm by 20 pmol). also suppressed (-29.5+/-3.4%;...
1. The effects of alpha,beta‐methylene ATP (alpha,beta‐MeATP) on membrane properties and excitatory junction potentials (EJPs) were examined in smooth muscle cells the guinea‐pig, rabbit pig bladder. 2. Intracellular recording with microelectrodes was used to record electrical activity from guinea‐pig (10(‐3) M) produced a rapid, large depolarization marked increase spike frequency, while carbachol (10(‐4) or acetylcholine (ACh; 10(‐4) only small no smaller frequency. alpha,beta‐MeATP...
Several reports claim that portal hypertension after living-donor liver transplantation (LDLT) adversely affects graft function, but few have assessed the impact of venous pressure (PVP) on regeneration. We divided 32 adult LDLT recipients based mean PVP during 1st 3 days into a group with > or = 20 mm Hg (H Group; n 17), and < (L 15). Outcome in H Group was poorer than L (58.8 vs. 92.9% at 1 year). Peak peripheral hepatocyte growth factor (HGF) 2 weeks higher (L: 1,730 pg/mL, H: 3,696...
1. The actions of cromakalim were studied on the detrusor muscle from guinea-pig urinary bladder. Cromakalim reduced frequency and amplitude spontaneous contractile activity smooth bladder at 5 x 10(-8)M abolished concentrations above 10(-7)M. 2. Electrophysiological experiments demonstrated that increased membrane conductance, caused a dose-dependent hyperpolarization cell loss spike activity. These events are consistent with opening K+ channels. 3. effects 10(-6)M 10(-5)M responses to...
Background: It has not been fully elucidated whether antihypertensive medication adherence affects blood pressure (BP) control in hypertension cases. Aim: To investigate the association of to drug regimens and BP using data from Combination Pill Losartan Potassium Hydrochlorothiazide for Improvement Medication Compliance Trial (COMFORT) study. Design: An observational analysis a randomized controlled trial. Methods: A total 203 hypertensive subjects were randomly assigned daily regimen...
The functional and anatomical results of distal end radius fractures with severe displacement in 22 elderly patients are reviewed this retrospective study. mean age the was 69.4 years (range, 60–88 years) follow-up period 24 months 12–53 months). According to sum demerit points (Saito, 1983), latest were ‘excellent’ 64% ‘good’ 36%. As for at follow-up, average radial tilt 20.7°, ulnar variance 4.0 mm, palmar −2.7° respectively. Though most had satisfactory outcome did not correlate...
Abstract —Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR). We tested whether angiotensin type 1 (AT ) receptor antagonist also EDHF-mediated responses combined AT blockade ACE inhibition exert any additional effects. SHR were treated with either TCV-116 (5 mg · kg − d (SHR-T), enalapril (40 (SHR-E), or their...
Blockade of the renin-angiotensin system improves impaired endothelium-dependent relaxations associated with hypertension and aging, partly through amelioration endothelium-derived hyperpolarizing factor (EDHF)-mediated responses. Although nature EDHF is still controversial, recent studies have suggested involvement gap junctions in EDHF-mediated Gap consist connexins (Cx), we therefore tested whether expression Cx vascular endothelial cells would be altered by antihypertensive treatment....
Xanthine oxidoreductase (XOR) is an enzyme responsible for purine degradation, reactive oxygen species production, and adipogenesis. XOR gene-disrupted (XOR(-/-)) mice demonstrate renal failure early death within several months. The aim of this study was to elucidate the mechanism damage in XOR(-/-) determine physiological role kidney. Histological analysis revealed that tubular accompanied by deposition crystals lipid-rich substances. Triglyceride content homogenates significantly increased...
To assess the efficacy and safety of apalutamide plus goserelin for androgen receptor (AR)-positive unresectable or recurrent/metastatic salivary gland carcinoma.
Background —The vascular endothelium releases endothelium-derived hyperpolarizing factor (EDHF). The mesenteric arteries of 6- to 8-month-old spontaneously hypertensive rats (SHRs) exhibit an impairment the hyperpolarization induced by acetylcholine via EDHF. Methods and Results —We determined whether antihypertensive treatment can improve EDHF-mediated responses in SHRs. Beginning at age 8 9 months, animals were treated with either enalapril (40 mg · kg −1 d ) (SHR-Es) or a combination...
Cognitive function is impaired in elderly subjects, so the aim of present study was to determine role arterial stiffness on cognitive function.Cognitive and were assessed by Mini-Mental State Examination (MMSE) measurement brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association MMSE score PWV studied 203 subjects (87 men, 116 women), all whom 85 years old. Sex distribution, systolic diastolic blood pressures did not differ between normal (MMSE >or=24, n=128)...
Abstract —Vascular relaxation via endothelium-derived hyperpolarizing factor (EDHF) declines in association with aging and also hypertension, antihypertensive treatment improves the endothelial dysfunction connected hypertension. We tested whether angiotensin-converting enzyme inhibitor EDHF-mediated responses normotensive rats, special reference to age-related process. Wistar-Kyoto rats (WKY) were treated either 20 mg · kg −1 d enalapril (WKY-E group) or a combination of 50 hydralazine 7.5...
Summary 1. Endothelial function is impaired in hypertension and ageing this may be associated with an increase cardiovascular disease. Several clinical studies have shown that blocking the renin–angiotensin system (RAS) improves endothelial not only hypertensive patients, but also normotensive patients 2. The aim of present study was to test whether endothelium‐derived hyperpolarizing factor (EDHF)‐mediated smooth muscle hyperpolarization relaxation are altered and, if so, chronic treatment...
Abstract The present study was designed to test whether hyperglycemia or hyperinsulinemia influences left ventricular mass and geometry. An echocardiogram 75-g oral glucose tolerance were performed in 210 normotensive 180 mildly moderately hypertensive male workers a bus company who free from cardiac diseases not taking medication for hypertension diabetes mellitus. When we divided subjects into four groups according the geometric pattern using index of 110 g/m 2 relative wall thickness...
SUMMARY 1. Acetylcholine (ACh) evokes endothelium‐dependent hyperpolarization in arterial cells, presumably through endothelium‐derived hyperpolarizing factor (EDHF). The identity of EDHF is still elusive; however, several recent studies suggest the possible involvement myoendothelial gap junctions response. 2. To elucidate role hyperpolarization, we examined effects junction inhibitors 18 α ‐glycyrrhetinic acid (18 ‐GA; 10 –4 mol/L) and carbenoxolone (3 × mol/L), a water‐soluble form β ‐GA,...
Background We previously demonstrated that the angiotensin converting enzyme (ACE) inhibitor, enalapril, prevents age-related impairment of endothelium-dependent hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor (EDHF). Objective To test whether II type 1 (AT1) receptor antagonists would also improve endothelial dysfunction. Methods Normotensive Wistar–Kyoto (WKY) rats were treated for 3 months with either AT1 antagonist, candesartan cilexetil (3.5 mg/kg...