A5044496367- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Dental Health and Care Utilization
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Oral microbiology and periodontitis research
- Advanced Glycation End Products research
- Diet and metabolism studies
- Dysphagia Assessment and Management
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Transport and Channel Regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal Development and Disorders
- Diabetes and associated disorders
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Hepatitis C virus research
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
Miwa Internal Medicine Clinic
2018-2022
Kyushu Dental University
1998-2007
Kyushu University
1996-2007
General Department of Preventive Medicine
2006
Tokushima University
2005
Kyushu University Hospital
2001
Harvard University
1994-1995
Joslin Diabetes Center
1994
National Hospital Organization Miyazaki Higashi Hospital
1990
Recent evidence has suggested that reactive oxygen species are important signaling molecules in vascular cells and play a pivotal role the development of diseases. The activity NAD(P)H oxidase been identified as major source endothelial cells. However, precise molecular structure mechanism activation have remained poorly understood.Here, we investigated identities superoxide-producing oxidase. We found Nox4, homologue gp91phox/Nox2, was abundantly expressed expression Nox4 markedly exceeded...
Reactive oxygen species (ROS) may play a critical role in the regulation of vascular tone and development diseases, such as stroke. NAD(P)H oxidase is major source ROS cells, including endothelial cells. It has been considered that Nox2 Nox4 are exclusively expressed among Nox homologues cells noncerebral blood vessels. However, precise molecular identity cerebral arteries not fully understood. We examined expression their activation mechanism arteries.We isolated cultured basilar artery...
Abstract Several clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on diabetic nephropathy. The underlying mechanisms are not fully understood. We found that administration canagliflozin at a low dose (0.01 mg/kg/day) did affect either blood glucose levels or glycosuria, but it improved albuminuria and mesangial expansion in db/db mice to similar extent as high (3.0 lowered levels. This indicated existence tubular SGLT2-independent...
Objective: Although tooth loss causes a decrease in masticatory ability, which may influence nutritional status, and impair an individual's general health including physical activity, little is known whether chewing ability could result deterioration fitness very elderly population. Thus, the present study evaluated relationship of or teeth number with measures sample 80‐years‐old Japan. Design: Cross‐sectional survey. Subjects methods: A total 1282 people who were 80‐years old resided...
Retinopathy and nephropathy are life-threatening diabetic complications that decrease patient quality of life. Although the mechanisms underlying these conditions have been extensively studied, they remain unknown. Recent reports demonstrated presence sodium glucose cotransporter 2 (SGLT2) in retinal pericytes mesangial cells. Hyperglycemia results functional morphological changes cells, but effects attenuated by phlorizin, a nonselective SGLT inhibitor. Based on findings, we hypothesized...
Abstract Antidiabetic sodium-glucose cotransporter 2 (SGLT2) inhibitors have attracted attention for their cardiorenal-protective properties beyond glucose-lowering effect. However, benefits in ischemic stroke remain controversial. Here we show the effects of luseogliflozin, a selective SGLT2 inhibitor, acute stroke, using permanent middle cerebral artery occlusion (pMCAO) model non-diabetic mice. Pretreatment with low-dose which does not affect blood glucose levels, significantly attenuated...
As quality of life (QOL) could be influenced by oral status in the elderly, we examined whether chewing ability or number teeth affected QOL 80-year olds. A cross-sectional survey included dental examination, self-assessment, and a questionnaire. total 823 people who were 80 years old participated this study. was assessed terms satisfaction with physical condition, meals, daily living social interactions, face-scale scores. After adjustment for gender, spouse activities living,...
The prevalence and clinical importance of orthostatic hypertension (OHT) in diabetic patients has not been elucidated, contrast to hypotension, which is occasionally found with autonomic neuropathy.The severity was investigated 277 Japanese male type 2 diabetes, including 90 hypertensive 128 nondiabetic age-matched subjects. Patients treated antihypertensive drugs were excluded from the study. OHT defined as an increase diastolic blood pressure (DBP) <90 >or=90 mmHg and/or systolic (SBP)...
Homogeneous cultures of calf glomerular mesangial and endothelial cells were found to be active in the synthesis type VI as well IV collagen contrast epithelial that devoted primarily production latter collagen. Studies with rat indicated they responded high glucose (20 mM) medium by a significant (P &lt; 0.001) increase measured protein its mRNA level, both which closely correlated each other consumption. Similar observations made collagen, but enhanced formation this was not rapidly...
Cognitive function is impaired in elderly subjects, so the aim of present study was to determine role arterial stiffness on cognitive function.Cognitive and were assessed by Mini-Mental State Examination (MMSE) measurement brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association MMSE score PWV studied 203 subjects (87 men, 116 women), all whom 85 years old. Sex distribution, systolic diastolic blood pressures did not differ between normal (MMSE >or=24, n=128)...
Purpose Mesangial cells play an important role in regulating glomerular filtration by altering their cellular tone. We report the presence of a sodium glucose cotransporter (SGLT) rat mesangial cells. This study aimed to evaluate expression and SGLT2. Methods The SGLT2 was assessed Western blotting reverse transcription-polymerase chain reaction (RT-PCR). Changes cell surface area at different concentrations effects extracellular Na+ Ca2+ SGLT Na+/Ca2+ exchanger (NCX) inhibitors on size were...
BACKGROUND:Diabetic macular edema (DME) causes serious visual impairments in diabetic patients. The standard treatments of DME are intra-vitreous injections corticosteroids or anti-vascular endothelial growth factor antibodies and pan-photocoagulation. These unsatisfactory their effects impose considerable physical economic burdens on the CASE REPORT:A 63-year-old woman was diagnosed as type 2 diabetes with retinopathy 7 years ago. Before initiation an SGLT2 inhibitor, dipeptidyl peptidase-4...
Background: Although diabetes mellitus and periodontal disease promote atherosclerosis, the relation of oxidative stress with these diseases remains unclear. To investigate influence on stress, we assessed effects initial therapy lipid peroxide (LPO), an index, in type 2 diabetic non‐diabetic patients. Methods: Seventeen subjects or without were enrolled this intervention study. No patient had a history cardiovascular peripheral vascular disease. Five six patients, all moderate to severe...
During cerebral ischemia, both hypoxia and hypercapnia appear to produce marked dilatation of the arteries. Hypercapnia may be accompanied by extracellular intracellular acidosis, which is another potent dilator However, precise mechanism acidosis produces arteries not fully understood. The objective present study was examine mechanisms basilar artery in vivo.Using a cranial window anesthetized rats, we examined responses sodium propionate, used cause specifically. Expression subunits...