A5030954230- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- IgG4-Related and Inflammatory Diseases
- Cancer Genomics and Diagnostics
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Medical Imaging and Pathology Studies
- Foreign Body Medical Cases
- Machine Learning in Bioinformatics
- Cancer Cells and Metastasis
- Gestational Trophoblastic Disease Studies
Kyushu University
2013-2025
Hudson Institute
2023
Sanno Medical Center
2023
Kitakyushu Municipal Medical Center
2018-2022
National Institute of Diabetes and Digestive and Kidney Diseases
2017
National Institutes of Health
2017
National Kyushu Medical Center
2017
The Japanese Society of Gastroenterological Surgery
2016
Abstract Background Recently, two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) have been proposed: the “Classical” and “Basal-like” subtypes, with former showing better clinical outcomes than latter. However, “molecular” classification has not applied in real-world practice. This study aimed to establish patient-derived organoids (PDOs) for PDAC evaluate their application subtype outcome prediction. Methods We utilized tumor samples acquired through endoscopic...
Although the combination of nanoliposomal irinotecan plus fluorouracil/folinic acid (nal-IRI/FF) exhibited survival benefits in gemcitabine-refractory patients with advanced pancreatic cancer (APC) phase III NAPOLI-1 trial, there is limited data on efficacy and safety this regimen real-world settings Japan. This multicenter, prospective observational study enrolled APC who received nal-IRI/FF after a gemcitabine-based from July 2020 to June 2021. We collected analyzed clinical conducted...
Abstract Background Streptozocin has been used to treat neuroendocrine tumors in Europe and the USA; however, its actual status Japan not fully clarified owing rarity of this disease relatively recent approval streptozocin Japan. Methods We retrospectively analyzed 53 patients with gastroenteropancreatic who were treated streptozocin-based chemotherapy at two Japanese hospitals between January 2004 June 2023. Results The overall response control rates 27.7 74.5%, respectively, median...
Currently, serum chromogranin A is a well-established biomarker for pancreatic neuroendocrine tumors; however, other diseases, oral use of proton pump inhibitor and renal impairment can affect A. Meanwhile, B, belonging to the same granin family as A, not fully examined in these conditions. The present study aimed evaluate utility B tumor biomarker. Serum levels were determined by radioimmunoassay enzyme-linked immunosorbent assay (n = 91) conditions, healthy people 104), assess...
We recently encountered the case of a patient with synchronous duodenal gastrointestinal stromal tumor (GIST) and pancreatic neuroendocrine (PNET). This is first report this specific combination multiple primary tumors, although three cases involving both PNET gastric GIST have previously been reported. Since developed close to uncus in case, we considered possibility PNETs differential diagnosis. However, histopathological examination using endoscopic ultrasonography-guided fine-needle...
VIPomas are generally rare functioning pancreatic neuroendocrine tumors (PanNETs) that cause watery diarrhea, hypokalemia, and achlorhydria. Due to their extreme rarity, the clinicopathological features outcomes of have not been well reported. This study aimed determine diagnostic therapeutic characteristics prognosis compare them with other PanNETs at a Japanese reference hospital. Medical records 293 patients were collected. Patient tumor retrospectively reviewed. cohort had only 1.4%...
Background/Aims: Although endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is performed globally, the procedure remains challenging. Guidewire manipulation most difficult step, and there are few reports on factors associated with unsuccessful guidewire manipulation. This study aimed to assess significance of puncture angle EUS images identify effective rescue method for patients manipulation.Methods: We retrospectively enrolled 115 who underwent EUS-HGS between May 2016 April 2022...
To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA + -M2BP) level as a marker for chronic pancreatitis (CP).We measured WFA+ -M2BP 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography and 30 normal controls (NC) using glycan sugar chain-based immunoassay investigated relationship between levels Cambridge classification CP.Serum was significantly higher in than NC (0.64 ± 0.28 vs 0.34 0.25, P < 0.001). The...
Although everolimus has become a key therapeutic agent in patients with advanced pancreatic neuroendocrine neoplasms (PNEN), its efficacy and safety clinical practice remains unclear.Forty-seven PNEN treated were reviewed retrospectively. To evaluate the of as long-term treatment, divided into two groups according to treatment duration: group A, ≤1 year (n = 21); B, >1 26).Among 42 tumors (PNET), median progression-free survival, overall objective response rate 27.5 months, 60.8 19.0%,...
Objectives This study aimed to evaluate the usefulness of 48-hour fasting test and insulin surrogates followed by a glucagon stimulatory (GST) for diagnosis insulinoma. Methods Thirty-five patients with suspected insulinoma who underwent GST were retrospectively included in our study: 15 surgically proven insulinomas 20 whom was clinically ruled out. We determined duration test, plasma glucose levels, serum levels immunoreactive C-peptide, (serum β-hydroxybutyrate, free fatty acid, response...
Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis an cell inflammation, leading “impaired autophagy flux”. promotes acinar-to-ductal transdifferentiation. Expression of amylase gets eliminated during the progression Amylase considered as marker; however, its function not known. Thus, we investigated whether affects and it plays any role development pancreatitis. Here,...
Objective The selective arterial secretagogue injection (SASI) test is considered indispensable for the accurate localization of insulinoma. However, optimum timing post-injection evaluation controversial, as some studies recommend 60 seconds [SASI (60 seconds)] while others support 120 (120 seconds)]. aim this study was to determine SASI insulinoma localization. Methods Thirteen patients with surgically proven were studied retrospectively. For test, immunoreactive insulin (IRI) determined...
This study aimed to evaluate the safety and efficacy of endoscopic transpapillary pancreatic duct stent placement (ETPS) for symptomatic peripancreatic fluid collection caused by postoperative fistula (POPF) after distal pancreatectomy (DP). ETPS was also compared with percutaneous drainage (PTD). Retrospectively 38 patients were studied who developed clinically relevant POPF. Of patients, 4 underwent PTD 11 ETPS. Technical clinical success rates (100% 91%, respectively) comparable 75%,...
A 56-year-old man with a walled-off necrosis (WON) underwent endoscopic necrosectomy using lumen-apposing metal stent (LAMS) (Hot Axios; Boston Scientific, Boston, Massachusetts, USA) ([Fig. 1 a]), which improved the abdominal inflammation within month. However, year after removal of LAMS, WON relapsed pain and elevated C-reactive protein (CRP) levels. Gastroscopy revealed that fistula caused by LAMS placement persisted, leakage necrotic material. Fluoroscopy also colonic associated in...
Abstract Aim Drug‐induced interstitial lung disease (DI‐ILD) is a serious adverse event during chemotherapy. This study aimed to obtain real‐world data of the incidence, clinical characteristics, predictive factors, and prognosis patients with pancreatic cancer who developed DI‐ILD. Methods In locally advanced or metastatic underwent standard chemotherapy at our hospital its participating facilities between April 2014 March 2019, features, occurrence rate course DI‐ILD, were retrospectively...
膵仮性嚢胞を合併した自己免疫性膵炎(AIP)12症例をもとに,膵仮性嚢胞の形成機序とステロイドの有効性について検討した.膵仮性嚢胞の発生部位は全例膵体尾部であり,10例の83%に膵管狭細化に伴う閉塞性膵炎を認めた.膵酵素上昇(75%)および腹痛(50%)も高率に認めた.ステロイド治療により膵仮性嚢胞は全例で消失し,膵管狭細像および閉塞性膵炎像も改善した.さらに,膵酵素上昇および腹痛も全例で改善した.以上より,AIPに合併する膵仮性嚢胞の形成機序は閉塞性膵炎に起因するものであり,AIPに合併する膵仮性嚢胞には閉塞性膵炎の解除を目的としたステロイド投与は有効であった.AIPの疾患概念が発信された当初は,閉塞性膵炎および膵仮性嚢胞の合併は稀と考えられていたが,今回の検討から膵仮性嚢胞の診療においてはAIPの可能性も念頭に置いた的確な診断と治療法の選択が重要と考えられた.
膵神経内分泌腫瘍は比較的稀な疾患であるが,近年注目されている領域である.機能性腫瘍と非機能性腫瘍に分けられるが,症状が認められてから診断までに時間がかかった症例も少なくなく,診断時既に遠隔転移が認められる症例も多い.基本的に悪性腫瘍であるが,治療方針を決定する上で,正確な診断(存在診断・局在診断・病理診断)が極めて重要である.多発性内分泌腫瘍症1型など遺伝性疾患を合併することがあり,治療開始前に鑑別しておく必要がある.診断における血中クロモグラニンA測定やソマトスタチンレセプターシンチグラフィによる腫瘍の局在診断は有用であり,欧米では使用されているが本邦では保険収載されていない.国際標準的な診断体系の本邦における確立が今後の課題である.
膵神経内分泌腫瘍(pancreatic neuroendocrine neoplasm:PanNEN)は希少疾患であるが,近年増加傾向である.超高齢社会に伴い今後はPanNEN患者の高齢化も予想される.PanNENの唯一の根治治療は外科切除であり,適応を選んで外科切除を施行した場合,高齢者においても安全な外科切除が可能である.一方で,年齢や併存疾患,腫瘍径などから,経過観察の選択肢も考慮する.高分化型の膵神経内分泌腫瘍(pancreatic tumor:PanNET)に対する全身療法として,ソマトスタチンアナログ,分子標的薬,細胞障害性抗がん剤,放射性核種標識ペプチド治療,などが挙げられる.各種治療法の特徴・有害事象を理解した上で,高齢者PanNETに適用することになるが,外科手術と同様に,併存疾患や認知機能などの事前評価が重要となる.