A5073656029- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Medical Imaging and Pathology Studies
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Biliary and Gastrointestinal Fistulas
- Inflammatory Bowel Disease
- Liver Disease and Transplantation
- Abdominal Surgery and Complications
- Pathogenesis and Treatment of Hiccups
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Nausea and vomiting management
- Gastrointestinal Bleeding Diagnosis and Treatment
Teikyo University
2021-2025
Tokyo Medical and Dental University
2018-2021
The University of Tokyo
2021
Saitama Medical University
2016
Yokohama Municipal Minato Red Cross Hospital
2014
Although various self-expandable metallic stents (SEMSs) for malignant hilar biliary obstruction (MHBO) have been introduced, the optimal SEMS MHBO has not yet established. This study aimed to evaluate outcomes of transpapillary placement an uncovered laser-cut with ultra-thin delivery sheath (YABUSAME) MHBO. multicenter, prospective was conducted in 11 hospitals 10 months (from March 2022 December 2022). The primary outcome stent patency rate at 6 months. Key secondary were technical...
Ulcerative colitis [UC] is a chronic inflammatory disease of the colon with an intractable course. Although goal UC therapy to achieve mucosal healing, pathogenesis injury caused by inflammation remains unknown. We therefore aim elucidate molecular mechanisms establishing in vitro and vivo humanised UC-mimicking models. An model using human organoids was established 60 weeks stimulation. The key gene for long-term identified microarray analysis. xenotransplantation into mouse colonic mucosa....
Tumor protein p53 (TP53) mutation is a well-known occurrence at the late phase of carcinogenesis during adenoma-carcinoma sequence sporadic colon cancer. Although numerous reports about clinical information patients with cancer have suggested that TP53 might be related to various types malignant potential, direct effects this on potential remain unknown. Notably, no previous report has described relationship between and stemness. We therefore aimed assess function mutant induced by...
Ulcerative colitis [UC] is a chronic inflammatory disease of the colon with frequent relapses. Telomere shortening in intestinal epithelial cells has been reported severe or longstanding cases. However, its influence on UC pathogenesis remains unelucidated. To this end, we evaluated telomere using long-term organoid inflammation model that had originally established. A human organoids was established to assess changes chronologically. MST-312 used for telomerase inhibition assay. The...
Sporadic adenoma or adenocarcinoma is often detected during endoscopic surveillance of patients with ulcerative colitis (UC). However, it occasionally difficult to distinguish these neoplasms from dysplasia colitis-associated cancers because the influence inflammation. inflammation on sporadic not well characterised. To assess this influence, we established a long-term model colon cancer cells by inflammatory stimulation tumour necrosis factor-α, flagellin and interleukin-1β for 60 weeks....
Endoscopic ultrasound-guided liver biopsy (EUS-LB) is a novel technique. We aimed to evaluate the efficacy and safety of EUS-LB in comparison with percutaneous (PLB).This retrospective study evaluated using 19-gauge fine needle (FNB) compared PLB spring-loaded 16-gauge patients diffuse disease at our hospital from April 2017 December 2020. The primary outcomes included total hepatic tissue surface area number portal tracts. Secondary success adverse event rates.Twenty each underwent PLB....
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Abstract Intraductal papillary mucinous neoplasm (IPMN) is a precancerous lesion of pancreatic cancer. Although there are 4 types IPMN, among which intestinal‐type IPMN likely to progress into invasive cancer known as colloid carcinoma, no information regarding the involvement intestinal phenotype in carcinogenesis exists. The present study was conducted explore how differentiation system maintained during tumor progression using surgical resection specimens. Results showed that Atoh1,...
Endoscopic ultrasound (EUS)-guided transluminal drainage has become a first-line treatment modality for symptomatic pancreatic pseudocysts. Despite the increasing popularity of lumen-apposing metal stents (LAMSs), plastic may resolve non-necrotic fluid collections effectively with lower costs and no LAMS-specific adverse events. To date, there been paucity data on appropriate stent type in this setting. This trial aims to assess non-inferiority LAMS initial EUS-guided The WONDER-02 is...
<title>Abstract</title> Background/Aims: The practice of endoscopic ultrasound-guided liver biopsy (EUS-LB) is becoming more common due to its proven safety and effectiveness. For accurate diagnosis, it vital secure ample tissue specimens. However, gauging the volume specimens accurately poses a challenge with existing methods. Additionally, determining most suitable fine-needle (FNB) needle requires further study. Our aim was contrast surface areas obtained using Franseen Fork-tip needles...
BACKGROUND: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is essential technique for sampling solid pancreatic lesions. However, the optimal needle type achieving high histological diagnostic capability remains unclear. This study compares capabilities of 19G FNA and 22G FNB METHODS: single-center, retrospective was conducted in patients who underwent EUS-TA Patients were allocated to either Group A, utilizing needle, or B, needle. The primary outcome accuracy based on histology...
Esophageal GISTs are rare tumors, accounting for 2%-5% of all GISTs. Imatinib mesylate has been reported to have an excellent effect in patients with unresectable and recurrent esophageal GISTs, however, there few reports on the adverse effects. We present first case report a patient GIST who developed pleuritis during treatment imatinib mesylate. A 67-year-old woman was referred us fever, cough dysphagia. CT showed large mass thoracic cavity. By endoscopic histopathological examinations,...
The goal of ulcerative colitis (UC) therapy has recently been to target mucosal healing. However, few drugs directly healing have developed. Although the effects investigational can be estimated using in vivo mouse model, it is unclear whether inflammation or damage. establishment an vitro system evaluate regeneration necessary for targeting We established chronic model by mice colonic organoids.1 aimed establish human primary colon organoids and therapeutic effect drug. This study was...
42歳男性.膵体部腫瘤を指摘され紹介.CTでは膵体部に早期相で低吸収,遅延相で不明瞭な14mm大腫瘤を認めた.被膜や嚢胞を疑う像は認めなかった.FDG-PETでは膵体部腫瘤に一致する集積を認めた.確定診断と治療方針決定目的でEUS-FNAを施行した.1回目は断片化した腺房細胞を認めるのみであり,再度FNAを施行.SPNに典型的な偽乳頭状構造は認めなかったが,偏在性の核と淡好酸性の明るい細胞質を有し胞体の空胞変性が目立つ帰属不明瞭な均一な細胞からなる小集塊が散見された.SPNを疑い免疫染色を行った.β-catenin,CD10陽性所見が得られ,FNA検体でSPNと術前診断した.膵体尾部切除術を行い,切除病理組織においてSPNと最終診断した.典型的な偽乳頭状構造を認めなくても,細胞質空胞が目立つ帰属不明瞭な細胞がみられた場合はSPNを疑い,免疫染色を含めたさらなる検討が必要であると考えられた.
In colitis-associated cancer (CAC), tumour protein p53 (TP53) mutation often occurs in the early phase of colon carcinogenesis known as dysplasia–carcinoma sequence. Although there are some reports about relation between TP53 and mice model, function on colonic epithelial cells patients with inflammatory bowel disease (IBD) has remained unknown. We therefore aimed to assess influence by using a CRISPR Cas9 system human organoids under long-term inflammation model which we originally...
Pneumatosis cystoides intestinalis (PCI) is a relatively rare disease characterized by multiple gas-filled cysts in the bowel wall. We report case of recurrent PCI patient with alcoholic cirrhosis, who was successfully treated oxygen supplementation via nasal cannula. A 57-year-old female being followed up at our hospital for cirrhosis presented persistent abdominal pain. CT showed pneumatosis large intestinal wall, and diagnosed. Although her symptoms were mild onset, they deteriorated 10...
A 71-year-old man was referred to our hospital and diagnosed with jaundice a liver function disorder. Although we suspected an intraductal papillary neoplasm of the bile duct (IPNB)-derived caudate branches on basis contrast-enhanced CT, MRI, endoscopic retrograde cholangiopancreatography, could not clearly identify tumor. Therefore, examined lesion using ultrasonography (EUS). We visualize iso-hyperechoic elevated tumor in branches. The observed as hypervascular EUS, which is useful...
Background and study aims We developed a self-expandable metallic stent (SEMS) with distal tapered end to reproduce the physiological bile flow pressure gradient due difference in diameter. aimed evaluate safety efficacy of newly covered metal (TMS) for malignant biliary obstruction (DMBO). Patients methods This single-center, prospective, single-arm was conducted patients DMBO. The primary endpoint time recurrent (TRBO), secondary endpoints were survival incidence adverse events (AEs)....
<div>Abstract<p>Tumor protein p53 (TP53) mutation is a well-known occurrence at the late phase of carcinogenesis during adenoma–carcinoma sequence sporadic colon cancer. Although numerous reports about clinical information patients with cancer have suggested that <i>TP53</i> might be related to various types malignant potential, direct effects this on potential remain unknown. Notably, no previous report has described relationship between and stemness. We therefore...
<p>The regulation of REG1A by TP53</p>
<p>CRISPR-mediated mutagenesis of TP53 in HCT-116 cells</p>
<p>CRISPR-mediated mutagenesis of TP53 in HCT-116 cells</p>