A5010393631- Geology and Paleoclimatology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
- Methane Hydrates and Related Phenomena
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Spine and Intervertebral Disc Pathology
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cryospheric studies and observations
- Heat shock proteins research
- Total Knee Arthroplasty Outcomes
- Receptor Mechanisms and Signaling
- Atrial Fibrillation Management and Outcomes
- Orthopaedic implants and arthroplasty
- Biomedical Ethics and Regulation
- Cardiac Structural Anomalies and Repair
- Knee injuries and reconstruction techniques
Lazarex Cancer Foundation
2020-2024
Wrightington Hospital
2024
TiVo (United States)
2024
NHS Blood and Transplant
2024
University of Minnesota
1998-2023
University of South Carolina
2021
New Hanover Regional Medical Center
2018-2020
US Forest Service
2020
University of Minnesota System
2019
University of Pennsylvania
1978-2018
The (230)Th ages and (234)U/(238)U ratios were determined for Barbados corals that grew during periods of high sea level within the last 200,000 years. similarity initial some to modern marine value suggests these samples are pristine ratio 83,000 years ago was 2 per mil value. accuracies evaluated on basis values a model behavior uranium thorium isotopes diagenesis. For three interglacial two intervening interstadial periods, peaked at or after peaks in summer insolation Northern...
A new classification method for CT/discography was developed. The Dallas discogram description (DDD) related five separate categories of information. Degeneration and annular disruption were regarded as phenomena. Additionally, provoked pain response, contrast volume, miscellaneous information recorded. Discogram findings 59 patients with low-back and/or leg graded according to the compared standard methods using routine anteroposterior lateral discographic images. Findings from discogra-phy...
This phase I study examined whether a heat shock protein (Hsp) 90 inhibitor tanespimycin (17-AAG; KOS-953) could be administered safely in combination with trastuzumab at dose that inhibits Hsp90 function vivo lymphocytes.Patients an advanced solid tumor progressing during standard therapy were eligible. Patients treated weekly followed by intravenous tanespimycin, assessed escalating levels.Twenty-five patients enrolled onto four levels: 225 (n = 4), 300 3), 375 8), and 450 mg/m2 10)....
In 2002, 2 million American women of reproductive age were infertile. Infertility is also common among men. The Centers for Disease Control and Prevention (CDC) conducts surveillance research on the causes infertility, monitors safety efficacy infertility treatment, sponsors national prevention programs. A CDC-wide working group found that, despite this effort, considerable gaps opportunities exist in surveillance, research, communication, program policy development. We intend to consult...
The passive permeability of isolated chromaffin vesicles to H+ and the internal pH under various conditions were measured. Potentiometric measurements K+ fluxes in presence selected ionophores uncouplers indicated that membrane is highly impermeable both protons potassium. deltapH across granule was measured by [14C]methylamine distribution. At 6.85, WAS 1.16 WITH THE INTRAVESICULAR SPACE BEING FOUND ACIDIC. Varying external produced an equivalent change deltapH, EXTRAPOLATION TO ZERO...
The CT/discographic findings from 225 discs in 91 low-back pain patients were compared to the provocation during injection of contrast into disc. radio-graphic appearance disc deterioration demonstrating degeneration and annular disruption each was classified separately using a fourpoint scale: normal, slight, moderate, or severe. Pain reaction discogram at level recorded as follows: no pain, dissimilar similar exact reproduction patient's clinical pain. This more precise analysis...
The effect of the transmembrane potential (delta psi) and proton concentration gradient pH) across chromaffin granule membrane upon rate extent catecholamine accumulation was studied in isolated bovine granules. Freshly granules had an intragranular pH 5.5 as measured by [14C]methylamine distribution. addition ATP to a suspension resulted generation potential, positive inside, [14C]thiocyanate (SCN-) carboxyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP), translocator, reversal negative...
The passive ion permeability, regulation of volume, and internal pH isolated bovine chromaffin granules were studied by radiochemical, potentiometric, gravimetric, spectrophotometric techniques. Chromaffin behave as perfect osmometers between 340 1,000 mosM in choline chloride, NaCl, KCl measured changes absorbance at 430 nm or from intragranular water measurements using 3H2O [14C]polydextran. By suspending iso-osmotic media various metal ions selectively increasing the permeability to...
Abstract The presence of the Brunhes-Matuyama magnetic reversal in deep-sea core sediments makes possible an alternative to usual K/Ar radioistope method dating as found rocks. uses correlations Northern Hemisphere summer insolation with oxygen-isotope ratios from tropical cores. latitude-dependent variations are calculated planetary mechanics and thus provide a highly accurate astronomical time scale. strongly influence glacial-ice volume fluctuations that dominate oxygenisotope ratio...
Abstract Starch, glycogen, maltooligosaccharides, and other α-1,4- α-1,6-linked glucose carbohydrates, exclusive of resistant starch, are collectively termed "dietary starch". This nutritionally important fraction is increasingly measured for use in diet formulation animals as it can have positive or negative effects on animal performance health by affecting energy supply, glycemic index, formation fermentation products gut microbes. AOAC Method 920.40 that was used measuring dietary starch...
Abstract The internal pH of lung lamellar bodies was investigated with membrane permeable basic amines. Isolated granular pneumocytes and isolated exhibited fluorescence when exposed to 8 microM quinacrine, suggesting accumulation this dye due an acidic pH. Uptake [14C]methylamine by measured quantitate the intralamellar body In KCl-ATP (10 mM) medium (pH 7.0), ratio methylamine (inside/outside) during 2-min incubation 8.1 +/- 0.47 (mean S.E., n = 8) indicating 6.1. Lamellar accumulated...
The marine record shows that over the last 350 ka Northern Hemisphere ice sheet volumes have fluctuated widely and only on rare short occasions they been reduced to present interglacial state. fluctuations are well synchronized with hemispheric average summer insolation variations of 20 periodicity caused by changing orbital parameters. development a model which explains varied amplitudes is consistent geological embodies following arguments: transition from an state like today's glacial...
The relationship between the electrochemical proton gradient (delta mu-H+) and for biogenic amines mu-A) was investigated in isolated chromaffin ghosts free of endogenous components gradients. addition ATP to a ghost suspension resulted generation large concentration pH), acidic inside (measured by [14C]-methylamine distribution), electrical psi), positive [14C]-thiocyanate distribution). In presence this gradient, accumulation [14C]5-hydroxytryptamine (serotonin) other rapidly reached an...
The effect of the transmembrane proton gradient (delta pH) and potential psi) upon rate extent amine accumulation was investigated in chromaffin ghosts. ghosts were formed by hypo-osmotic lysis isolated bovine granules extensive dialysis order to remove intragranular binding components dissipate endogenous electrochemical gradients. Upon ATP addition suspensions ghosts, a alone, or both, could be established, depending compositions media which resuspended. When chloride present medium,...
The effect of the transmembrane proton gradient (delta pH) and potential psi) upon rate extent amine accumulation was investigated in intact 5-hydroxytryptamine (serotonin) containing dense granules. granules were isolated purified from other subcellular organelles under isotonic conditions utilizing a newly developed continuous density Percoll. As measured by [14C]methylamine distribution, suspended highly buffered medium at pH 7.0 had an intragranular 5.40, independent external medium....
The [14C]methylamine distribution method was utilized to measure the internal pH of isolated serotonin containing granules pig blood platelets under varying conditions. used were by a new protocol which stressed platelet rupture controlled conditions and preservation isotonicity throughout isolation procedure, In well buffered external medium, 6.85, deltapH measured as 1.11 with being found acidic (pH 5.74). Increasing produced corresponding increase in deltaH. gradient could be collapsed...