We prepared a molecular photodiode system in which the photocurrent direction can be switched by choosing wavelength of an irradiating light. The is composed two types helical peptides that carry different chromophores and have directions dipole moments when they are immobilized on gold. mixed, self-assembled monolayer generated anodic one was photoexcited, whereas to being cathodic other chromophore photoexcited. opposite current response arises from moment each peptide, accelerates...

Well-ordered self-assembled monolayers (SAMs) were prepared on gold from helical peptides carrying a ferrocene (Fc) moiety at the N- or C-terminal end, and long-range electron transfer (ET) Fc to was investigated. Electrochemical studies revealed that an inelastic hopping mechanism dominated over superexchange in ET reactions present SAMs dipole moment of helix accelerated probably due lowering barrier height between surface peptide layer.

Nonionic amphiphilic copolypeptides, which were composed of hydrophilic poly(sarcosine) and hydrophobic poly(gamma-methyl L-glutamate) blocks, synthesized with varying chain lengths the blocks. The polypeptides having a suitable balance found to form vesicular assemblies 100 nm size in buffer, was evidenced by TEM observation, DLS analysis, encapsulation experiment. genuine peptide vesicles, peptosomes, labeled near-infrared fluorescence (NIRF) probe. In vivo retention blood experiment...

Take the stepping stones: Electrons are exchanged between both termini of α-helical peptide self-assembled monolayers (SAMs) on gold by a hopping mechanism with amide groups as sites (see picture). The rate constant 0.45 s−1 for 64-mer is significantly high electron transfer through dielectric organic materials. Detailed facts importance to specialist readers published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted...

Self-assembled monolayers (SAMs) of α-helical peptides carrying an N-ethylcarbazolyl (ECz) group were prepared. The helical peptide SAMs on a gold surface characterized by quartz crystal microbalance measurements, cyclic voltammetry, and impedance spectroscopy, showing that tridecapeptide SAM with the N-terminal binding to was packed more densely than C-terminal binding. helix tilt angles from normal in these found be about 40° basis Fourier transform infrared reflection−absorption...

Several hydrophobic α-helical peptides containing a disulfide group were synthesized, and the formation of oriented self-assembled monolayers (SAMs) on gold surface was investigated. The orientation helices in SAMs determined by Fourier transform infrared reflection−absorption spectroscopy measurements. tilt angle helix axis from normal sensitively affected choice solvent used preparation SAMs, nature component amino acids, molecular structure (either one-helix or two-helix peptide), length...

Self-assembled monolayers of α-helical peptides were prepared on gold, and the effects monolayer structures (kind constituent amino acid, molecular orientation, packing) long-range electron transfer through helical studied. The 16mer having a thiophenyl linker at N-terminal for immobilization gold redox active ferrocene moiety C-terminal as an electron-transfer probe. immobilized by gold−sulfur linkage from to was studied electrochemical methods. When two types peptides, one with repeating...

Amid-Trittsteine: Zwischen den Enden α-helicaler Peptide, die sich in selbstorganisierten Monoschichten (SAMs) auf einer Goldoberfläche befinden, findet ein Elektronenaustausch statt, wobei Amidgruppen als Zentren für Hüpfvorgang fungieren (siehe Bild). Die Geschwindigkeitskonstante von 0.45 s−1 das 64-mere Peptid ist ungewöhnlich hoch einen Elektronentransfer durch organisches Dielektrikum. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such...

Two types of peptide nanotubes, one is prepared from an amphiphilic having a right-handed helix segment and the other that left-handed segment, are shown to transform morphology into vesicle by membrane fusion due stereo-complex formation between these helical segments.

Nanoparticles are expected to be applicable for the theranostics as a carrier of diagnostic and therapeutic agents. Lactosome is polymeric micelle composed amphiphilic polydepsipeptide, poly(sarcosine) 64 ‐ block ‐poly( l ‐lactic acid) 30 , which was found accumulate in solid tumors through enhanced permeability retention effect. However, lactosome captured by liver on second administration mouse. This phenomenon called accelerated blood clearance phenomenon. On other hand, peptide‐nanosheet...

The in-depth structural analysis of spherulites artificial cellulose, formed by the enzymatic polymerization cellobiosyl fluoride, is reported. Both positive- and negative-type were observed polarization optical microscopy. Scanning electron microscopy revealed that negative have a three-dimensional round shape, where platelike single crystals cellulose originate radially from center. Transmission confirmed chains orient vertically in crystals, explaining observation Cellulose can be easily...

Abstract An apolar synthetic octapeptide, Boc‐(Ala‐Aib) 4 ‐OMe, was crystallized in the triclinic space group P1 with cell dimensions a = 11.558 Å, b 11.643 c 9.650 α 120.220°, β 107.000°, γ 90.430°, V 1055.889 Å 3 , Z 1, C 34 H 60 O 11 N 8 ·H 2 O. The calculated crystal density 1.217 g/cm and absorption coefficient ϕ 6.1. All intrahelical hydrogen bonds are of 10 type, but torsion angles, ψ, Ala(5) Ala(7) deviate from standard values. distortion ‐helix at C‐terminal half is due to...

A novel molecular system, where the photocurrent direction can be reversibly switched by changing pH of solution, was prepared on gold from helical peptides carrying a photosensitizer and carboxyl group at terminal. Upon photoexcitation in an aqueous solution containing electron donor acceptor 10, monolayer generated anodic due to enhancement dipole moment carboxylate anion, while it opposite cathodic 3.4

Octadecapeptides carrying a ferrocene moiety at the molecular terminal were self-assembled on gold, and long-range electron transfer from to gold was investigated by electrochemical methods. Effects of dipole moment helical peptides, linkers connecting peptide chromophores introduced into side chains discussed. Cyclic voltammetry monolayers in an aqueous solution revealed that over 40 Å occurred along molecule. Chronoamperometry showed should be ascribed hopping mechanism with use amide...

Abstract Helical peptides of 8mer, 16mer, and 24mer carrying a disulfide group at the N ‐terminal ferrocene moiety C were synthesized, they self‐assembled on gold by sulfur–gold linkage. Infrared reflection–absorption spectroscopy ellipsometry confirmed that formed monolayer with upright orientation. Cyclic voltammetry showed electron transfer from to occurred even longest peptide. Chronoamperometry electrochemical impedance carried out determine standard rate constants. It was found...

Amphiphilic block polypeptides having a helical hydrophobic with uniform chain length and hydrophilic nonionic were newly synthesized self-assembled into homogeneous nanotubes ca. 60 nm diameter 200 length. The tubular assembly was shown to be elongated by heating over micrometer without changing the diameter. Notably, distinctive three-way nanotube obtained just mixing two kinds of amphiphilic same but different lengths block. morphology molecular assemblies tunable from curved sheet-shaped...

The assembly of molecular architectures on the basis dipoles is proposed here to be a promising tool for construction nanomaterials and nanodevices. Three kinds building blocks having are discussed; helical peptides, cyclic β-peptides, oligo(phenylene ethynylene)s donor acceptor substituents. Secondary interactions involving shown effective control precise shapes assemble in regular manner. Furthermore, can generate strong electric field at nanoscale, which useful promotion or suppression...

pH-Responsive molecular assemblies with a variation in morphology ranging from twisted ribbon, helical to nanotube were prepared novel A3B-type amphiphilic peptide having three hydrophilic poly(sarcosine) (A block) chains, hydrophobic dodecapeptide (B block), and two histidine (His) residues between the A3 B blocks. The adopted morphologies of ribbon at pH 3.0, 5.0, 7.4, depending upon protonation states His residues. On other hand, another one residue blocks showed change only relatively...