A5021063392- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Organ Transplantation Techniques and Outcomes
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Anesthesia and Sedative Agents
- Pancreatic function and diabetes
- Neuroblastoma Research and Treatments
- Transplantation: Methods and Outcomes
- Cannabis and Cannabinoid Research
- Colorectal and Anal Carcinomas
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
Oslo University Hospital
2005-2015
University of Oslo
1983-2008
Med-Storm Innovation (Norway)
2005
Skedsmo Medisinske Senter
2004
National Hospital for Neurology and Neurosurgery
1995-2001
University College London
1995-2001
Institutt for Eksperimentell Medisinsk Forskning
1978-1986
In Brief Objective: The objective of this pilot study was to investigate the potential for long-term overall survival (OS) after liver transplantation colorectal metastases (CLMs). Background: Patients with nonresectable CLMs have poor prognosis, and few survive beyond 5 years. are currently considered an absolute contraindication transplantation, although primary some secondary malignancies shows excellent outcome in selected patients. Before 1995, several transplantations were performed,...
Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal epithelium. Typically, periampullary have either intestinal pancreatobiliary type of differentiation, and differentiation might be prognostically more important than anatomic site origin. The aim study was to determine whether histologic is an independent prognostic factor adenocarcinoma, tumour origin predicts prognosis carcinomas independently resection...
Early detection of the highly aggressive malignancy cholangiocarcinoma (CCA) remains a challenge but has potential to render tumor curable by surgical removal. This study evaluates biomarker panel for diagnosis CCA DNA methylation analyses biliary brush samples. The status 13 candidate genes ( CDO1 , CNRIP1 DCLK1 FBN1 INA MAL SEPT9 SFRP1 SNCA SPG20 TMEFF2 VIM and ZSCAN18 ) was investigated in 93 tissue samples (39 CCAs 54 nonmalignant controls) using quantitative methylation‐specific...
The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This should be evaluated by serial perpendicular sectioning. aim of the study was to determine whether involvement independently predicts survival after pancreaticoduodenectomy within a framework standardized assessment resected specimens. 114 consecutive macroscopically margin-free adenocarcinomas were examined according prospective protocol for histopathologic...
The incidence of colorectal cancer (CRC) increases with age and early onset indicates an increased likelihood for genetic predisposition this disease. somatic genetics tumor development in relation to patient remains mostly unknown. We have examined the mutation status five known critical genes at diagnosis, compared genomic complexity tumors from young patients without CRC syndromes those elderly patients. Among 181 patients, stratified by microsatellite instability status, DNA sequence...
To analyze the immediate and long-term outcome after laparoscopic resection of colorectal liver metastases difference between observed predicted [Fong's Basingstoke Predictive Index (BPI) scores] survivals.: Laparoscopic has been reported safe feasible improves postoperative course. The oncologic outcomes are poorly reported.Between August 1998 January 2010, 122 patients underwent for during 135 procedures at Rikshospitalet. Patients undergoing surgery June 2009 were included in research...
The introduction of laparoscopic liver resection has been challenging because new and safe surgical techniques have had to be developed, skepticism remains about the use laparoscopy for malignant neoplasms. We present herein a large-volume single-center experience with resection.Retrospective study.Rikshospitalet University Hospital.One hundred thirty-nine patients who underwent 177 resections in 149 procedures from August 18, 1998, through October 14, 2008. One thirteen lesions, whom 96...
Cholangiocarcinoma is notoriously difficult to diagnose, and the mortality rate high due late clinical presentation. CpG island promoter methylation frequently seen in cancer development. In present study, we aimed at identifying novel epigenetic biomarkers with potential improve diagnostic accuracy of cholangiocarcinoma. Microarray data analyses cholangiocarcinoma cell lines treated drugs their untreated counterparts were compared previously published gene expression profiles primary tumors...
Abstract Background Laparoscopic resection is regarded as safe and feasible in selected patients with benign pancreatic tumours. Few data exist on laparoscopic surgery for malignant lesions larger neoplasms unselected patients. Methods The study included all admitted to Oslo University Hospital, Rikshospitalet, from March 1997 2009 of the body tail pancreas, head, who underwent by a approach curative intent. Results A total 166 had 170 operations, including 138 resections, 18 explorations,...
Abstract Introduction Laparoscopic adrenalectomy for metastases is considered controversial. Multicenter retrospective study was performed to gain new knowledge in this issue. Materials and Methods From January 1997 till November 2008, 41 adrenalectomies were during follow‐up of the patients operated malignant tumors. The median age 64 (52–77) years. Metastases confirmed 31/41 cases. Metastatic lesions further studied define factors influencing on survival, divided sub‐groups...
This is a retrospective study of 32 consecutive patients referred in the period 1992-2000 for management serious bile duct injuries caused by elective laparoscopic cholecystectomy.The were on median 29 days (0 to 34 months). Only 7 immediately after discovery injury. At local hospital, 25 underwent various procedures attempts at repair. Ten treated strictures previous repairs other hospitals.At referral, 23 (72%) had complete transection duct, while 9 leakage injuries. Additional...
Objective. The aim of this study was to delineate the clinical outcomes and pathological characteristics surgically resected endocrine tumors pancreas determine importance World Health Organization (WHO) tumor-node metastasis (TNM) classifications, resection status, Ki-67 expression for long-term survival. Patients methods. Sixty-nine patients underwent surgical tumor with curative intent during 1990–2007. Hospital records were reviewed retrospectively medical, surgical, pathological,...
AbstractTo examine the role of bicarbonate as mediator NaCl reabsorption, acetazolamide was administered in a small or conventional dose (30 mg/kg body wt) and large (500 to anaesthetized dogs during inhibition distal reabsorption by ethacrynic acid. During saline infusion, acid reduced sodium 65 ± 2% chloride 55 filtered load. The inhibitory effect almost twice that dose. At control glomerular filtration rate (GFR) 26 2%, 25 1% 18 3% Both three ions two per ion. After dose, bicarbonate,...
AbstractTo examine the characteristics of transcellular, energy-requiring NaCl reabsorption, increased delivery tubular fluid different bicarbonate and chloride composition to outer medulla was achieved by infusion acetazolamide (30 mg/kg body wt) or 0.9% in anaesthetized dogs. As an index transport, cortical outermedullary metabolism were determined heat production technique. Outer medullary correlated sodium excretion but not excretion. A rise up 20-25% filtered load during hydropenia...
The ratio between changes in sodium reabsorption and renal oxygen consumption (Na/O2) was measured anesthetized dogs at high plasma bicarbonate concentration (32 +/- 1 mM); ethacrynic acid infused continuously to prevent variations transcellular NaCl when altered by varying PCO2 glomerular filtration rate (GFR). At (110 mmHg) varied proportion GRF 50 125% of control GFR (glomerulotubular balance). By reducing 20 mmHg, reduced 50-60% constant GFR. Na/O2 not significantly different during the...