A5074669488- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Diverticular Disease and Complications
- COVID-19 and Mental Health
- Education, Healthcare and Sociology Research
- BRCA gene mutations in cancer
- Clinical practice guidelines implementation
- Inflammatory Bowel Disease
- Breast Cancer Treatment Studies
- Gastrointestinal disorders and treatments
- Health Promotion and Cardiovascular Prevention
- AI in cancer detection
- Lung Cancer Diagnosis and Treatment
University of Oslo
2016-2025
Oslo University Hospital
2016-2025
Forskning.no (Norway)
2024
Harvard University
2014-2023
Cancer Registry of Norway
2009-2022
Telemark Hospital
2011-2019
Frontier Science & Technology Research Foundation
2018-2019
Frontier Science Foundation
2019
Inland Hospital
2019
Harvard–MIT Division of Health Sciences and Technology
2018
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). The Grading Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to define strength recommendations quality evidence. <b>Main recommendations:</b> following for post-polypectomy endoscopic surveillance should be applied only after a high baseline colonoscopy with complete removal all detected neoplastic lesions. <b>1</b> In low risk group (patients 1 – 2 tubular...
Although colonoscopy is widely used as a screening test to detect colorectal cancer, its effect on the risks of cancer and related death unclear.We performed pragmatic, randomized trial involving presumptively healthy men women 55 64 years age drawn from population registries in Poland, Norway, Sweden, Netherlands between 2009 2014. The participants were randomly assigned 1:2 ratio either receive an invitation undergo single (the invited group) or no usual-care group). primary end points...
A challenge in quantifying the effect of screening mammography on breast-cancer mortality is to provide valid comparison groups. The use historical control subjects does not take into account chronologic trends associated with advances awareness and treatment.The Norwegian program was started 1996 expanded geographically during subsequent 9 years. Women between ages 50 69 years were offered every 2 We compared incidence-based rates death from breast cancer four groups: two groups women who...
Colorectal cancer is a major health burden. Screening recommended in many countries.To estimate the effectiveness of flexible sigmoidoscopy screening on colorectal incidence and mortality population-based trial.Randomized clinical trial 100,210 individuals aged 50 to 64 years, identified from population Oslo city Telemark County, Norway. was performed 1999-2000 (55-64-year age group) 2001 (50-54-year group), with follow-up ending December 31, 2011. Of those selected, 1415 were excluded due...
Main Recommendations The following recommendations for post-polypectomy colonoscopic surveillance apply to all patients who had one or more polyps that were completely removed during a high quality baseline colonoscopy. 1 ESGE recommends with complete removal of – 4 < 10 mm adenomas low grade dysplasia, irrespective villous components, any serrated polyp without do not require endoscopic and should be returned screening. Strong recommendation, moderate evidence. If organized screening is...
Although colonoscopic surveillance of patients after removal adenomas is widely promoted, little known about colorectal-cancer mortality among these patients.Using the linkage Cancer Registry and Cause Death Norway, we estimated who had undergone colorectal during period from 1993 through 2007. Patients were followed 2011. We calculated standardized incidence-based ratios (SMRs) using rates for Norwegian population at large comparison. guidelines recommended colonoscopy 10 years with...
<h3>Importance</h3> Although some countries have implemented widespread colonoscopy screening, most European not introduced it because of uncertainty regarding participation rates, procedure-related pain and discomfort, endoscopist performance, effectiveness. To our knowledge, no randomized trials on screening currently exist. <h3>Objective</h3> investigate rate, adenoma yield, adverse events population-based in several countries. <h3>Design, Setting, Population</h3> A clinical trial was...
Background: Precise quantification of overdiagnosis breast cancer (defined as the percentage cases that would not have become clinically apparent in a woman's lifetime without screening) due to mammography screening has been hampered by lack valid comparison groups identify incidence trends attributable versus those temporal incidence. Objective: To estimate screening. Design: Comparison invasive with and Setting: A nationwide program Norway (inviting women aged 50 69 years), gradually...
Abstract Update to this article In October 2022, three years after the initial publication of guideline, first trial effect colonoscopy screening was published. The implications new evidence for current recommendations were evaluated by guideline panel in January 2023. judged that did not alter recommendations, and therefore an update following needed (see table 2 details). Clinical question Recent 15-year updates sigmoidoscopy trials provide on effectiveness colorectal cancer screening....
To estimate the benefits, burden, and harms of implementing computer aided detection (CADe) polyps in colonoscopy population based screening programmes for colorectal cancer. Microsimulation modelling study. Cost effectiveness working package OperA (optimising cancer prevention through personalised treatment with artificial intelligence) project. A parallel guideline committee panel (BMJ Rapid recommendation) was consulted defining interventions selection outcome measures. Four cohorts 100...
<h3>Objective</h3> Although serrated polyps may be precursors of colorectal cancer (CRC), prospective data on the long-term CRC risk in individuals with are lacking. <h3>Design</h3> In a population-based randomised trial, 12 955 aged 50–64 years were screened flexible sigmoidoscopy, while 78 220 comprised control arm. We used Cox models to estimate HRs 95% CIs for among ≥1 large polyp (≥10 mm diameter), compared adenomas at screening, and population controls, multivariate logistic regression...
Patients with cancer who use statins appear to have a substantially better survival than nonusers in observational studies. However, this inverse association between statin and mortality may be due selection bias immortal-time bias.To emulate randomized trial of therapy initiation that is free bias.We used data on 17 372 patients from the Surveillance, Epidemiology, End Results (SEER)-Medicare database (2007-2009) complete follow-up until 2011. The SEER-Medicare links US registries claims...
The long-term effects of sigmoidoscopy screening on colorectal cancer (CRC) incidence and mortality in women men are unclear.To determine the effectiveness flexible after 15 years follow-up men.Randomized controlled trial. (ClinicalTrials.gov: NCT00119912).Oslo Telemark County, Norway.Adults aged 50 to 64 at baseline without prior CRC.Screening (between 1999 2001) with additional fecal blood testing versus no screening. Participants positive results were offered colonoscopy.Age-adjusted CRC...
<b>Objective</b> To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. <b>Design</b> Pooled analysis randomised trials (the US Prostate, Lung, Colorectal Ovarian trial (PLCO), Italian Screening Colon Rectum (SCORE), Norwegian Cancer Prevention (NORCCAP)). <b>Data sources</b> Aggregated data were pooled from each on incidence mortality stratified sex, age at screening, colon subsite (distal <i>v</i> proximal)....
Norway and Sweden have similar populations health care systems, but different reactions to the COVID-19 pandemic. closed educational institutions, banned sports cultural activities; kept most institutions training facilities open. We aimed compare peoples' attitudes towards authorities control measures, perceived impact of pandemic implemented measures on life in Sweden.Anonymous web-based surveys for individuals age 15 or older distributed through Facebook using snowball method, from...
Background: Effective breast cancer screening should detect early-stage and prevent advanced disease. Objective: To assess the association between size of detected tumors to estimate overdiagnosis (detection that would not become clinically relevant). Design: Cohort study. Setting: Denmark from 1980 2010. Participants: Women aged 35 84 years. Intervention: Screening programs offering biennial mammography for women 50 69 years beginning in different regions at times. Measurements: Trends...
<b>Background:</b> Current guidelines recommend surveillance colonoscopies after polyp removal depending on the number and characteristics of polyps, but there is a lack evidence supporting recommendations. This report outlines rationale design two randomized trials one observational study investigating evidence-based strategies following removal. <b>Study endpoints:</b> The EPoS studies started to recruit patients in April 2015. I randomizes 13 746 with low-risk adenomas (1 – 2 tubular size...
BACKGROUND: Artificial intelligence using computer-aided diagnosis (CADx) in real time with images acquired during colonoscopy may help colonoscopists distinguish between neoplastic polyps requiring removal and nonneoplastic not removal. In this study, we tested whether CADx analyzed helped decision-making process. METHODS: We performed a multicenter clinical study comparing novel CADx-system that uses real-time ultra-magnifying polyp visualization standard visual inspection of small (≤5 mm...