A5052191676- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Connective tissue disorders research
- Cardiovascular Health and Disease Prevention
- Cell Adhesion Molecules Research
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Diagnosis and Treatment of Venous Diseases
- Peroxisome Proliferator-Activated Receptors
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Lipoproteins and Cardiovascular Health
- Abdominal Surgery and Complications
- Congenital Heart Disease Studies
- Vascular Procedures and Complications
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Issues in Pregnancy
- Flow Measurement and Analysis
- Thermoregulation and physiological responses
- RNA modifications and cancer
University of Oslo
2010-2022
Oslo University Hospital
2012-2022
Maastricht University
2015
Aarhus University Hospital
2008
Med-Storm Innovation (Norway)
2005
Although the participation of inflammation in atherogenesis is widely recognized, identification different components has not been clarified. In particular, role plaque destabilization fully understood.Our main findings were as follows: (1) a microarray experiment, we identified visfatin, one most recently adipokines, gene that was markedly enhanced carotid plaques from symptomatic compared with asymptomatic individuals. This finding confirmed when 7 patients and 14 lesions examined...
Background The NLR family, pyrin domain containing 3 ( NLRP 3) inflammasome is an interleukin IL )‐1β and ‐18 cytokine processing complex that activated in inflammatory conditions. role of the pathogenesis atherosclerosis myocardial infarction not fully understood. Methods Results Atherosclerotic plaques were analyzed for transcripts inflammasome, ‐1β release. Swedish First‐ever Infarction study Ac‐county FIA ) cohort consisting DNA from 555 patients 1016 healthy individuals was used to...
The risk for cardiovascular events is related to the composition and stability of an atherosclerotic plaque driven by inflammation deposition lipids. Scavenger receptors are a family cell surface involved in lipid uptake inflammation. Recently, we found that soluble CD36 increased plasma from patients with diabetes strongly correlated insulin resistance.We tested whether marker high-grade internal carotid stenoses (n=62). were classified according symptomatology echogenicity on ultrasound...
Background and Purpose— Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with central role inflammation. We hypothesize that IL-23 also important atherogenesis investigate this population carotid atherosclerosis. Methods— Plasma levels of were measured patients artery stenosis healthy controls. The mRNA its receptor, IL-23R, atherosclerotic plaques, nonatherosclerotic vessels, peripheral blood mononuclear cells, plasmacytoid dendritic cells....
Background Atherosclerosis is a major cause of cerebrovascular disease. Matrix metalloproteinases (MMPs) play an important role in matrix degradation within the atherosclerotic lesion leading to plaque destabilization and ischemic stroke. We hypothesized that MMP-7 could be involved this process. Methods Plasma levels were measured 182 consecutive patients with moderate (50–69%) or severe (≥70%) internal carotid artery stenosis, 23 healthy controls. The mRNA plaques different symptomatology,...
Background and Purpose— Cerebral microembolic signals detected by transcranial Doppler are frequent during carotid angioplasty with stenting endarterectomy (CEA). Their potential harmful effects on the brain are, however, unclear. The aim of this study was to relate frequency type per-procedural procedure-related ipsilateral ischemic strokes new lesions diffusion-weighted cerebral MRI. Methods— Eighty-five patients who were prospectively treated CEA (61) or (30) for high-grade (≥70%)...
Background and Purpose Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking associated inflammation. To further elucidate the of FABP4 atherogenesis humans, we examined regulation carotid atherosclerosis ischemic stroke. Methods We plasma levels asymptomatic (n = 28) symptomatic 31) patients with atherosclerosis, as well 202 subjects acute In a subgroup also analysed expression within atherosclerotic lesion. addition,...
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been shown to be increased in patients with acute ischemic stroke. Here, we evaluated plasma sLOX-1 levels and vascular carotid plaque LOX-1 (ie, OLR1) gene expression stroke transient attack (TIA) particular focus on their relation time since symptom onset.Plasma (n=232) OLR1 (n=146) were who referred evaluation for endarterectomy, as well healthy control (n=81). Patients categorized according presence of or (n=35)...
Abstract Background To explore survival, causes of death, and the prevalence cardiovascular events in a Norwegian Marfan syndrome (MFS) cohort. MFS is heritable connective tissue disorder associated with reduced life expectancy–primarily due to aortic pathology. Methods A follow‐up study 84 adults, initially investigated 2003–2004. In 2014–2015, 16 were deceased, 47 68 survivors consented new clinical investigations. Analyses performed for deceased at follow‐up. Standardized mortality ratios...
Abstract Aims We aimed to assess the prevalence of mitral annulus disjunction (MAD) and explore association with aortic disease valve surgery in patients Marfan syndrome (MFS) Loeys–Dietz (LDS). Methods results included consecutive MFS fulfilling Revised Ghent Criteria LDS Nosology. MAD was identified by echocardiography quantified as longitudinal distance from ventricular myocardium hinge point posterior leaflet. Aortic events were defined dissection or prophylactic surgery. recorded need...
Background Carotid artery plaque inflammation is thought to be an important marker of vulnerability and increased stroke risk. Aim The main aim this study was assess the level agreement between 2-deoxy-2-[ 18 F] fluoro-D-glucose (18F-FDG) uptake on PET (positron emission tomography) scan in carotid plaques, with cerebrovascular symptoms, ultrasound echogenicity histological assessments inflammation. Methods Thirty-six patients ≥70% stenosis scheduled for endarterectomy underwent a Colour...
AimsThe homeostatic chemokines, CCL19 and CCL21 their receptor CCR7, have recently been linked to atherogenesis. We investigated the expression of CCL19/CCL21/CCR7 in carotid atherosclerosis as well ability these chemokines modulate lipid accumulation macrophages vascular smooth muscle cell (SMC) phenotype.
Several studies suggest a pro-atherogenic role for the CC chemokine receptor 2 (CCR2), thought to reflect interaction with monocyte chemoattractant protein (MCP)-1. Based on its ability attract leucocytes into inflamed tissue, we hypothesized MCP-4, another CCR2 ligand. Our main findings were: (i) patients symptomatic carotid stenosis (n = 29), but not those asymptomatic plaques 31), had significantly raised plasma levels of MCP-4 compared healthy controls 20); (ii) in vitro, releasate from...
Atherosclerosis is a progressive chronic disease, in which inflammation plays key role. The calcium-binding proteins calgranulins including S100A8, S100A9, and S100A12 are involved many cellular activities pathological processes inflammation. We therefore hypothesized that may be markers of plaque instability patients with carotid atherosclerosis.Plasma levels S100A8/A9 S100A10 were measured 159 consecutive high-grade stenosis 22 healthy control subjects. mRNA also within the atherosclerotic...
Aim Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role atherosclerosis unclear. In this study we investigated the expression of IL-27 and receptor patients with carotid if could modulate effects NLRP3 inflammasome vitro. Methods Plasma was measured by enzyme immunoassay stenosis (n = 140) healthy controls 19). Expression IL-27R analyzed quantitative PCR immunohistochemistry plaques from non-atherosclerotic vessels. THP-1 monocytes, primary monocytes...
Abstract Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed a genetic variant the human repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, explored role Neil3/NEIL3 atherogenesis by both clinical and experimental approaches. Human carotid plaques revealed mRNA expression which significantly correlated levels macrophage marker CD68. Apoe −/− Neil3 mice on high-fat diet accelerated plaque formation as...
Objective: To report our experience with endovascular stentgraft repair of diseases the descending thoracic aorta in high risk patients. Methods: Twenty-one procedures were performed 20 patients (10 women), aged 22–81 years, for disease Gore Excluder endoprosthesis™ (WL Gore) (n=11) and Talent LPS Stent Graft System (Medtronic AVE) (n=10). All considered operative risk. Diagnoses included saccular aneurysm, aneurysm rupture, mycotic penetrating atherosclerotic ulcer, aortic dissection...
The first publication of Loeys–Dietz syndrome (LDS) described aortic rupture at young ages. Experience with new LDS types showed that the clinical course varies, and thresholds for prophylactic surgery are discussed. As this is an uncommon disease, experience needs to be shared. Retrospective review patients 1–4 undergoing cardiovascular during years 1991–2016. Thirty-five (including 6 children LDS2) underwent 57 operations. 1, 2, 3 4 included 4, 17, 11 patients, respectively. Mean age was...