A5089644471- Complement system in diseases
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Renal Diseases and Glomerulopathies
- Bariatric Surgery and Outcomes
- Fatty Acid Research and Health
- Clostridium difficile and Clostridium perfringens research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Health Promotion and Cardiovascular Prevention
- Bacterial Infections and Vaccines
- Mechanical Circulatory Support Devices
UiT The Arctic University of Norway
2016-2025
Nordland Hospital Trust
2015-2025
Nordland Hospital
2014-2023
University of Oslo
1988-2015
Smerteklinikken
2015
Institutt for Eksperimentell Medisinsk Forskning
2015
Akershus University Hospital
2005
Abstract Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark atherosclerotic lesions. CC appear early in the atheroma trigger inflammation by NLRP3 inflammasome activation. In this study we hypothesized whether employ complement system to activate inflammasome/caspase-1, leading release mature IL-1β, activation regulates CC-induced cytokine production. describe that activated both classical alternative...
OBJECTIVE It is of vital importance to elucidate the triggering factors obesity and type 2 diabetes improve patient care. Bariatric surgery has been shown prevent even cure diabetes, but mechanism unknown. Elevated levels lipopolysaccharide (LPS) predict incident sources LPS are not clarified. The objective current study was evaluate potential impact plasma on abdominal glycemic control in subjects undergoing bariatric surgery. RESEARCH DESIGN AND METHODS This a prospective observational...
The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast Saccharomyces boulardii have been suggested to improve left ventricular ejection fraction (LVEF).In multicentre, prospective randomized open label, blinded end-point trial, we patients LVEF <40% New York Heart Association functional class II or III, despite optimal medical therapy,...
Abstract Background Interactions between the gut microbiota, diet, and host metabolism contribute to development of cardiovascular disease, but a firm link disease-specific microbiota alterations circulating metabolites is lacking. Methods We performed shot-gun sequencing on 235 samples from 166 HF patients 69 healthy control samples. Separate plasma controls ( n = 53) were used for comparison imidazole propionate (ImP) levels. Taxonomy functional pathways shotgun data was assigned using...
Complement component C5 is crucial for experimental animal inflammatory tissue damage; however, its involvement in human inflammation incompletely understood. The responses to gram-negative bacteria were here studied taking advantage of genetic complement-deficiencies--nature's own knockouts--including a previously undescribed defect. Such deficiencies provide unique tool investigating the biological role proteins. conditions allowed cross-talk between different pathways using whole blood...
Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by gut microbiota dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation carnitine via microbiota-dependent intermediate γ-butyrobetaine (γBB). Elevated levels are associated with cardiovascular disease (CVD), but little known about obesity. Given proposed contribution alterations obesity type 2 diabetes (T2D), we investigated potential impact obesity,...
Delayed leukocytosis after strenuous exercise is well documented, but the underlying mechanisms are not clear. In this study, we investigated relationship between exercise-induced muscle damage and delayed leukocytosis, by utilizing an extreme eccentric protocol.We obtained blood samples from 11 healthy men before 300 maximal actions with m. quadriceps. Maximal force-generating capacity was tested regularly during 7 d exercise. Blood analyzed for leukocytes, growth hormone (GH), cortisol,...
Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- microinfarctions cognitive decline, even in the presence of adequate oral anticoagulation. AF strongly related to inflammatory activity whereby anti-inflammatory agents can reduce new or recurrent AF. However, it not known whether therapy also modify deterioration neurocognitive function older patients In present study, were treated intensive lipid-lowering atorvastatin 40 mg...
Background Increasing evidence implicates innate immunity in the pathogenesis of congestive heart failure (CHF). In present study, we examined possible role complement, an important part immunity, CHF. Methods and Results Complement activation was analyzed systemic coronary circulation 39 patients with CHF 20 healthy control subjects. a double-blind, placebo-controlled have recently reported that high-dose intravenous immunoglobulin (IVIG) improves left ventricular ejection fraction (LVEF)...
During infections, polymorphonuclear neutrophilic granulocytes (PMN) are mobilized from their bone marrow stores, travel with blood to the affected tissue, and kill invading microbes there. The signal(s) inflammatory site unknown, even though a number of humoral factors that can mobilize PMN, well known. We have employed standardized, non-infectious human model elucidate relevant PMN mobilizers. Well-trained athletes performed 60-min strenuous strength workout leg muscles. Blood samples were...
Abstract Exposing blood to an artificial surface results in a systemic inflammatory response, including cytokine release and complement activation. We studied the surface‐induced inflammation human whole using extensive panel of mediators proinflammatory cytokines, chemokines growth‐factors investigated role system induction this response. Using multiplex technology, 27 different were measured after circulating for 4 hours polyvinyl chloride tubing. The C3 inhibitor compstatin was used block...
There is increasing evidence that the metabolic syndrome associated with a proinflammatory state. Interleukin-18 (IL-18) has been shown to be multiple components of and predict development diabetes cardiovascular events. The aim present work was investigate if exercise could reduce serum levels IL-18 in subjects syndrome, potential changes would body composition syndrome. Pravastatin used for comparison.We investigated effect 12 weeks intervention exercise, pravastatin, or both on 34...
Abstract Low‐density lipoprotein (LDL) apheresis is well‐established in selected patients with uncontrolled LDL levels. As such treatment affects biomarkers important atherosclerosis and acute coronary syndromes, we systematically compared the inflammatory response induced by three columns. Three heterozygous familial hypercholesterolemia participated a cross‐over study six consecutive treatments different columns: DL‐75 (whole blood adsorption), LA‐15 (plasma EC‐50W filtration). Biochemical...
Sinus node dysfunction is often due to degeneration of the heart’s impulse-generating system. We report a case 40-year-old woman with recent gastric sleeve surgery, who presented symptomatic sinus bradycardia following significant post-surgical weight loss. Extensive workup excluded common causes such as electrolyte disturbances, hypothyroidism, or cardiomyopathy. hypothesize that alterations in leptin metabolism loss triggered increased vagal stimulation, leading her bradycardia. The...
Abstract Background Sex-differences in cardiac ageing are unclear. We aimed to analyse the sex-differences left ventricle (LV) structure and function over 11 years of among healthy middle-aged participants Nord-Trøndelag Health Study, third (HUNT3, 2006–2008) fourth (HUNT4, 2017–2019) waves. Methods analyzed echocardiographic demographic data from 266 (20-75 years); 132 women (age 50.3±11.2 years, Body mass index (BMI) 25.7±4 kg/m²) 134 men 51.1±10.9 BMI 26.8±3 at HUNT3 with follow-up using...
Background: Congestive heart failure (CHF) is associated with persistent immune activation. Medical therapy has been shown to exert only limited anti‐inflammatory effects. Cardiac resynchronization (CRT) reduces morbidity and mortality in a subset of patients failure, but it not known whether this treatment affects the system as well. To test hypothesis, eight scheduled for CRT were investigated activation before 6 months after treatment. Methods Results: After months, all had improved...