Study Design. Single blind randomized study. Objectives. To compare the effectiveness of lumbar instrumented fusion with cognitive intervention and exercises in patients chronic low back pain disc degeneration. Summary Background Data. authors’ best knowledge, only one study has evaluated fusion. The Swedish Lumbar Spine reported that was better than continuing physiotherapy care by family physician. Patients Methods. Sixty-four aged 25–60 years lasting longer 1 year evidence degeneration at...

The management of minimal, mild and moderate head injuries is still controversial. In 2000, the Scandinavian Neurotrauma Committee (SNC) presented evidence-based guidelines for initial these injuries. Since then, considerable new evidence has emerged.General methodology according to Appraisal Guidelines Research Evaluation (AGREE) II framework Grading Recommendations Assessment, Development (GRADE) system. Systematic review Preferred Reporting Items Reviews Meta-Analyses (PRISMA)...

The effectiveness of lumbar fusion for chronic low back pain after surgery disc herniation has not been evaluated in a randomized controlled trial. aim the present study was to compare with posterior transpedicular screws and cognitive intervention exercises. Sixty patients aged 25-60 years lasting longer than 1 year previous were randomly allocated two treatment groups. Experienced surgeons performed fusion. Cognitive consisted lecture intended give patient an understanding that ordinary...

Background: The Scandinavian Neurotrauma Committee was initiated by the Neurosurgical Society to develop evidence-based guidelines for improved care of neurotrauma patients. Methods: A MEDLINE search identified 475 papers dealing with management minimal, mild, and moderate head injuries. Forty-two studies presenting class II evidence on initial such injuries were reviewed developed. Results: Implementation Head Injury Severity Scale is advocated. Patients minimal (no loss consciousness,...

OBJECTIVE To investigate the role of prophylactic hyperdynamic postoperative fluid therapy in preventing delayed ischemic neurological deficits attributable to cerebral vasospasm. METHODS We designed a prospected, randomized, controlled study and included 32 patients with subarachnoid hemorrhage. Sixteen received hypervolemic hypertensive hemodilution therapy; other 16 normovolemic therapy. All were monitored for at least 12 days, clinical assessments, transcranial Doppler recordings,...

OBJECTIVE The present study was conducted to validate S-100 protein as a marker of brain damage after minor head injury. METHODS We studied 50 patients with injuries and Glasgow Coma Scale scores 13 15 in whom computed tomographic scans the revealed no abnormalities. Serum levels were measured at admittance hourly thereafter until 12 hours Magnetic resonance imaging baseline neuropsychological examinations performed within 48 hours, follow-up 3 months postinjury. RESULTS Fourteen (28%) had...

This study was designed to investigate the correlation between S-100 protein serum measurements and neuroradiological findings in patients with head injury. We studied 278 minor, moderate, severe injuries 110 controls no history of neurological disease. The recruited from three Scandinavian neurotrauma centers. Serum levels were measured at admittance, computed tomographic scans brain obtained within 24 h postinjury all patients. In a subgroup 45 minor injuries, magnetic resonance imaging...

Background and Purpose— Wall shear stress (WSS) pressure are important factors in the development of cerebral aneurysms. We aimed to develop a computational fluid dynamics simulator for flow complete circle Willis study impact variations vessel radii bifurcation angles on WSS walls. Methods— Blood was modeled with Navier-Stokes equations as an incompressible newtonian within rigid A model geometry approximated network tubes around cubic curves. Pulsatile inlet rates constant outlet were used...

Object. The angles of arterial bifurcations are governed by principles work minimization (optimality principle). This determines the relationship between angle a bifurcation and radii vessels. Nevertheless, model is predicated on an absence significant communication these branches. circle Willis changes this because vessels proximal to ring have additional factors that determine compared with more distal must impact understanding shear stress aneurysm formation. authors hypothesized normal...

Background: Mild head injury (MHI) implies a risk for traumatic brain and even small development of an intracranial hematoma. Head computed tomography (CT) is recommended early detection such pathologic findings. The present multicenter study was performed to investigate whether determination protein S100B in serum could contribute the selection patients CT scanning. Methods: We included 226 with history Glasgow Coma Scale (GCS) score 13 15 at admission hospital. Blood samples analysis were...

Background and Purpose— Cerebral artery aneurysms rupture when wall tension exceeds the strength of tissue. At present, risk-assessment unruptured does not include evaluation lesions shape, yet clinical experience suggests that this is importance. We aimed to develop a computational model for simulation fluid-structure interaction in cerebral based on patient specific lesion geometry, with special emphasis tension. Methods— An advanced isogeometric analysis incorporating flexible aneurysm...

Loss to follow-up may bias the outcome assessments of clinical registries. In this study, we wanted determine whether outcomes were different in responding and non-responding patients who included a spine surgery registry, at two years follow-up. addition, identify risk factors for failure respond.633 operated degenerative disorders lumbar followed 2 using local registry. Those did not attend clinic those answer postal questionnaire-for whom data missing-and would be lost according standard...

<b>Objective</b> To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy short (6 weeks), intermediate (12 and long term (52 weeks). <b>Design</b> Multicentre, blinded, randomised controlled trial. <b>Setting</b> Outpatient multidisciplinary back clinics five Norwegian hospitals. <b>Participants</b> Between October 2005 February 2009, 461 patients assessed for inclusion (presenting with &gt;12 328 excluded cauda equina syndrome, severe paresis,...

Purpose: This study of patients with minor head injury was designed to investigate the relation S-100 protein measurements computed tomograpy (CT) findings and outcomes. Increased serum levels this were hypothetized predict intracranial pathology increased frequency post-concussion symptoms. Methods: One hundred eighty-two studied Glasgow Coma Scale scores 13-15. The recruited from three Scandinavian neurotrauma centres. Serum measured at admittance CT scans brain obtained within 24 hours...

Background: S100B, a protein abundant in astroglial cells within the central nervous system, has been shown to increase cerebrospinal fluid and serum after various neurologic diseases. However, cerebral specificity of S100B questioned. This study aims show levels uncomplicated bone fractures patients without current or prior Methods: Blood for sampling was drawn from seeking care at emergency department presenting with orthopedic no older than 24 hours having previous suspected disorder head...

Objective: To evaluate the prevalence of sexually transmitted infections (STIs) and mode presentation in patients originating from Bangladesh resident United Kingdom comparison with non-Bangladeshi attending an inner London genitourinary medicine (GUM) clinic. Methods: A retrospective, cross sectional study comparator group was carried out at open access GUM clinic east London. 104 consecutive newly Bangladeshi men were compared 199 115 women 218 women. Any diagnosed infections, sexual...

Objective: The incidence of aneurysmal subarachnoid hemorrhage (aSAH) ranges from 4 to 10 per 100,000 person-years in most countries, and 30-day case fatality is high. aim this study was estimate the aSAH assess preictal predictors survival 2 large Norwegian population-based cohort studies. Methods: A total 94,976 adults (≥20 years) Nord-Trøndelag Health Study 31,753 participants (aged ≥20 Tromsø were included. During follow-up, aSAHs identified, rates estimated, assessed using Cox Poisson...